Drug delivery leaps biotech hurdles
...eeded in the body. These include the attachment of targeting molecules, such as monoclonal antibodies and receptor ligands, to carriers such as liposomes, polymer particles, and nanospheres. A number of labs are even learning how to use soccer-ball-shaped fullerene molecules or algae skeletons as cages to carr...Researchers identify cause of aggressive childhood cancer
...ful model, the scientists turned to a "conditional targeting approach" that enabled them to knock out SNF5 in...ncer model, Roberts and Orkin took the conditional targeting a step further. They engineered the knockout system so that instead of being snipped out, the SNF5 ...Non-invasive imaging technique detects plaques beginning to form in vessels
..., like a Mr. Potato Head," Wickline explains. "The targeting agent allows us to select where the particle goes, and then we can either add an imaging agent, like gadolinium, or a drug, like plaque stabilizing medications or anticancer agents." The team injected nanoparticles loaded with avb3 detectors and gado...New genetic option for thwarting cancer
... finding opens up a new option for cancer therapy: targeting the Cdk4 gene or the enzyme it produces. "This is an outstanding target, particularly since so many cancer cell types and precancerous tissues have faulty tumor suppressor genes," Kiyokawa said. According to Kiyokawa, the Cdk4 gene normally accelerat...Acorda Therapeutics acquires CeNeS neuregulin products
... products, and has research and development assets targeting pain, schizophrenia, addiction and sleep disorders. CeNeS is based in Cambridge, England. For further information please visit http://www.cenes.co.uk ....Gene increases schizophrenia risk, says study
...f medications outside the dopamine system, perhaps targeting the protein produced by the gene," suggests Seeman. The study was supported by the National Alliance for Research on Schizophrenia and Depression, the Eli Lilly Research Fellowship in Women's Mental Health, the Stanley Foundation Scholars Mentors Pro...NIST genetics research lends a hand in World Trade Center IDs
...on (PCR). NIST designed new PCR primers--tools for targeting the amplification (copying) to a specific DNA segment--that reduce the size of the amplified regions by 100 base pairs or more. Smaller PCR products amplify better than large ones when genomic DNA is degraded....Scientists produce the script for life
...harmaceutical industry will develop based on drugs targeting breakdowns in genome regulatory networks. Perhaps we can correct some problems even before a faulty protein is produced," predicts Young. The group is already working on doing the same analysis for the human genome, whose regulatory network consists ...World-first gene therapy for cystic fibrosis targets lung stem cells?
...cularly exciting because they imply we are in fact targeting airway stem cells through this approach - some of the therapeutic gene must have been passed on from these parent stem cells to their daughter cells for the effect to persist beyond three months," Dr Parsons says. Research funding is now being s...Study holds promise for stroke, schizophrenia treatments
...to take a new approach in designing medications by targeting the receptor interactions directly, says Liu. The next step will be to study the D1 and NMDA interactions in an animal model, she adds. Other researchers participating in the study included Xian-Min Yu, an assistant professor in U of T's Faculty of D...Natural insecticide identified as potential cancer prevention agent for early stage lung cancer
...cells to chemotherapy and irradiation. Therefore, targeting Akt using deguelin may enhance the effectiveness of chemotherapy and radiation therapy and increase the apoptotic potential of NSCLC cells." The goal of chemoprevention for lung and other cancers is development of a specifically targeted agent with m...Study backs theory that accumulating mutations of 'quiet' genes foster aging
...ggests the aging process might be safely slowed by targeting genes that are quiet early but threaten damage later in life has gotten a boost from new findings from the University of Illinois at Urbana-Champaign. The researchers don't promote such tinkering in their paper, which appears online this week in adva...RRF recycles form, not exact function
...e to become resistant to antibiotics, we must keep targeting parts of bacteria that are integral for functioning so that bacteria can not out-evolve antibiotics," said Kaji. "We are considering RRF as the target of a new type of antibiotic, an inhibitor of RRF that we can easily alter as bacteria become resist...Wrong proteins targeted in battle against cancer?
...se obstacles could possibly be overcome by instead targeting certain transcription factors. He says that these ...in interactions have failed, Darnell believes that targeting protein-protein interactions is the next logical step. "With the availability of robotic screening ...Emory to receive more than $6.5 million to study environmental risk factors for Parkinsons disease
...Health. Clinical and basic research projects, all targeting gene-environment interactions in Parkinson's disease, will be led by Dr. Greenamyre, Allan Levey, M.D., Ph.D., professor of neurology, Emory University School of Medicine and director of the Emory Neurodegenerative Disease and Gary Miller, Ph.D., ass...HIV targets active genes in cells
...st 23, issue of the journal Cell. "HIV seems to be targeting not just genes, but active genes," said Salk resea...team. "That makes a lot of biological sense if the targeting has evolved to promote efficient expression of the viral genome once it integrates into the cell." T...Researchers discover how herpes tricks the immune system
... and immunology and of molecular microbiology. "By targeting this viral protein or by manipulating the complement system, perhaps someday we can develop better treatments for herpes virus infections." The complement system consists of about 20 different proteins that are transported in the bloodstream. When ac...Unraveling the genetics behind melanoma and colon cancer
...icipate that anti-cancer therapies based on Nr-CAM targeting will be easier than with molecules expressed inside the cell....Structure of key receptor unlocked; Related proteins will fall like dominoes
...rtain breast cancer patients, different strategies targeting HER2 might also prove effective. Having a protein's structure allows scientists to conceive new strategies and pursue new classes of drugs, says Leahy. A focus of many scientists because of the proteins' involvement in cell growth, the HER family ar...Antiretroviral therapy in HIV-infected children can stop neurological damage
...doctors treat children with antiretroviral therapy targeting both the blood and central nervous system. "In the context of the current debate on when to initiate antiretroviral therapy in children, one must take into consideration potentially reversible early neurologic manifestations, which may be under-appre...