Leader in cancer treatment and prevention research honored
...el agents which hit and disable specific molecular targets in the skin, thus reversing severe sun damage, and we have initiated diagnostic studies of early precancerous lesions in the breast, using novel nipple lavage capabilities." Dr. Alberts will give an award lecture, entitled "Cruising Down the Chemopre...Researchers find color sensitive atomic switch in bacteria
...and their exposed proteins are the most accessible targets to treat human tissue or destroy infectious microbes, he said. More than 60 percent of medications target membrane proteins on human cells and many antibiotics target membranes on pathogens....Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...mmals have, in addition, an adaptive response that targets specific invaders. This involves antibody-producin...ls mobilized against antigens, which are molecular targets expressed by microbes, viruses or cancer cells. One of the problems with cancer antigens is that tha...Award winning researchers reveal potential new role for Glivec
...bsets of more common diseases where PDGFR or other targets are activated....High resolution satellite imagery assists hunt for infectious 'kissing bugs'
Their targets are blood-sucking reduviid insects, generally known as 'kissing bugs' because they emerge from their hiding places each night to bite human skin where it is thinnest around the mouth and eyes. Growing up to five centimetres long, the kissing bugs a...Gene clusters predict atherosclerosis severity, susceptibility
...e implicated in the disease process and may become targets of future therapies," Seo continued. "By identifying variants within these genes, we may be able to identify combinations of such variants that when taken together with known clinical risk factors, may lead to new prognostic and diagnostic tools for ...UCSF scientist Joe Derisi named MaCarthur Fellow
...ducing a protein, points to numerous new potential targets for drug and vaccine therapy. DeRisi is acutely aware of the need for such therapies, noting that Third World diseases such as malaria have not been a prime focus of pharmaceutical companies. "If you have an infectious disease like mal...Wisconsin scientists develop quick botox test
...the toxin enters cells. Inside the cell, the toxin targets three key proteins, which are essential for mediating the release of chemical signals from neurons and that governs how messages are sent from brain to muscles. "The toxins are smart," Chapman notes. "They know where to go" inside cells to do the mos...Brown research reveals key insight into memory-making
... in the hippocampus. The new research provides new targets for drugs or other treatments for these conditions. Esther Penick and Jeffrey Edwards, postdoctoral research fellows in Kauer's lab, worked on the study as did Mikyoung Park, a Duke graduate student. The National Institutes of Health, the American He...$7.5 Million grant to Yale researchers for role of viruses in cancer
...ported by this grant will continue to identify new targets for therapy and suggest new approaches to prevent and treat cancers," said principal investigator Daniel DiMaio, M.D. , Waldemar Von Zedtwitz Professor of Genetics and vice chair of the Department of Genetics . DiMaio studies human papillom...Key stimulator of colorectal cancer identified
...ptember issue of Cancer Cell, identifies potential targets for future therapeutics aimed at the prevention and treatment of cancer of the colon and rectum. Colorectal cancer (CRC) is the second most common cause of death due to cancer for men and women in the United States It has been known for some time tha...Washington University in St. Louis leads group studying aging process
...lready are drawing interest from drug companies as targets for new therapies."...First glimpse of DNA binding to viral enzyme
... numerous locations along it that could be used as targets for drugs to block the interaction and act as antiviral agents, Mangel said. The scientists have already begun looking for such drugs and hope to have the National Institutes of Health test some of them for anti-viral activity within a year. ...Gene expression in liver tumors and patient prognosis
... stage, it may be possible to identify therapeutic targets that can slow the course of disease progression," ...portant, expression profiling will reveal specific targets for rational therapy." ...Researchers identify distinctive signature for metastatic prostate cancer
...lopamine, a drug discovered by Beachy's group that targets another protein in the pathway, Smoothened, inhibited growth of these cell lines. Furthermore, they showed that when the tumor cells were introduced into mice, cyclopamine caused a permanent regression of the tumors. "We interpreted the finding in...Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets
...ly a few target molecules. "The limited number of targets NEDD8 has despite the fact that its E1, E2 and E3 ...the tail fits into make these structures potential targets for new drugs. "Novel drugs that are designed to disrupt the tail, the groove or both might block t...Proteins show promise for mosquito control
...d is selected, it works for a short period, and it targets a single insect. "People might ask, 'Why do we need more pesticides?'" Lan says. The answer is twofold: resistance and the effect on non-target species. "I believe you should develop smart pesticides to only kill the mosquitoes," Lan says. "We don't...Adaptive changes in the genome may provide insight into the genetics of complex disease
...ying regions of thehuman genome that have been the targets of natural selection will provideimportant insights into recent human evolutionary history and may alsohelp us understand and identify the genetic contribution to various complexdiseases," Akey said. The findings appear to provide support for a theo...Broken arms and collateral damage: clues to predator-driven evolution
...d Gahn suspect that crinoids were not the intended targets of the predators that inflicted damage upon them, and that their broken arms were simply "collateral damage." Crinoids, Baumiller explained, play host to a variety of other organisms that take up residence on various parts of their bodies, and the pr...Identifying tick genes could halt disease, bioterrorism threat
... new way," Hill said. "We will be able to identify targets for development of novel insecticides to control ticks and new vaccines to control the pathogens they carry."...