EMBO Gold Medal 2004 goes to Spanish scientist
...rch led to the landmark discovery of the mammalian telomerase RNA component. Subsequently Blasco knocked out the telomerase RNA in the mouse producing a powerful tool to understand the role of telomerase on cancer and aging....Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
... to survive if the cancer cells are expressing the telomerase gene. This finding, from investigators at St. Jude... not survive. "Overall, our results indicate that telomerase gene expression is associated with an unfavorable outcome for children being treated for osteosarcom...The telomere crisis: A crucial stage in breast cancer
...erase, which can restore telomeres. Cells in which telomerase is activated can then proliferate indefinitely to ...g cancer can be identified in advance by measuring telomerase activity, genome instability, and other signals in the clinic. The findings also point to possible ...Neurologists create a font of human nerve cells
...ility to continuously divide. With the newly added telomerase gene, the spinal progenitor cells were able to con...eam solved the problem by introducing the gene for telomerase at just the right moment in the cell's lifetime, when it has committed to a particular spinal cell t...JCI table of contents, February 2, 2004
...s (parts of antigen molecules) derived from murine telomerase reverse transcriptase (mTERT) an enzyme expressed in more than 80% of human tumors as potential anticancer vaccines. In the February 2 issue of the Journal of Clinical Investigation they report that epitopes with a low affinity for HLA class I mole...Researchers learn certain enzyme inhibitors may help in cancer therapy following initial procedures
...s of tumor cells but not healthy cells, indicating telomerase inhibitors may be a powerful new approach to chemo...man tumor cells with a unique compound that blocks telomerase activity, and the cell proliferation slowed substantially after just a few weeks. Further, prostate ...University of Rochester scientists test new method to attack cancer
... anopportunity for researchers who are focusing on telomerase in a bid todevelop a drug like none ever developed...for Cancer Research in Washington, D.C. The enzyme telomerase produces telomeres, located at the ends of each chromosome, which protect the ends of chromosomes as...Scientists find genetic link between cancer and premature aging
...zyme that extends the lifespan of cells. "Although telomerase is important for immortalizing cells, it's not sufficient in all cell types," she said. "We asked, 'What other gene could be important for preventing senescence?' The Werner syndrome gene was an obvious candidate." Using human cells grown in the labo...'Immortalized' cells enable researchers to grow human arteries
...ter, Ph.D., had previously cloned the hTERT (human telomerase reverse transcriptase subunit) component of the enzyme telomerase that stops telomeres from shortening, and had shown that expression of hTERT permitted some human ce...Double research boost for tissue engineering community
...human primary cells that have been immortalised by telomerase transfection to ensure that the data generated relate to 'normal' cell behaviour. The materials chosen for the study will represent those that are commonly used in implants e.g. polymers, ceramics, stainless steel and titanium. Characterisation and ...Effects of rare, devastating disease linked to shrinking of cells' telomeres
... and dies. In cancer cells, activity of the enzyme telomerase maintains the length of the telomeres and consequently the cells keep dividing long past their normal life span. In humans, AT is a genetic disease that occurs in about 1 in 40,000 births. Beginning in the first few years, patients gradually lose th...Umbilical cord matrix, a rich new stem cell source, study shows
...ed to express foreign proteins. The cells exhibit telomerase activity, a key indicator of stem cells, and they can be induced to form nerve cells, both neurons and glia, that produce a range of nerve-cell specific traits. Neurons are the nervous system cells that transmit signals; glial cells support the neuro...Mutation in DKC1 gene can cause rare aging disease and cancer
... This showed that the primary cause of DC was not telomerase impairment. Rather, the deregulated ribosome function found in Dkc1 mutant mice was the primary cause of the syndrome. Telomerase deficiency may nevertheless exacerbate the disease and needs further study. Our results proved that mutations to the DKC...Researchers create DNA 'nanocircles' to probe the mystery of aging in human cells
... sequences to the end of the telomere. But because telomerase is difficult to produce in the lab, Kool and his c...s, one of the things it has to do is switch on the telomerase gene which makes the telomeres longer," he said. "The body has decided that the best way to keep an ...Targeting enzymes that immortalize cancer cells: if you can't turn them off, round them up
...sociate professor Kathleen Collins discovered that telomerase is walled off from the chromosomes of normal cells...s, on the other hand, have found a way to mobilize telomerase continually so they can quickly double and redouble while keeping the telomeres intact. Some cancer ...Discovery of chromosome-capping activator could aid cancer research
...tists previously believed to be part of the larger telomerase enzyme is actually a separate unit that sweeps in ... researchers are looking for treatments that block telomerase activity as a way of killing tumors. The discovery of a specific activator protein may offer an attr...Protozoan chosen for genome sequencing
...ructure of telomeres (ends of chromosomes) and the telomerase enzyme, which has profound importance in cancer and aging. Sequencing of Tetrahymena will have many benefits, including informing the biology of the causative agent of malaria and other related protist pathogens of great medical or agricultural sign...NHGRI prioritizes model organisms for sequencing
...ructure of telomeres (ends of chromosomes) and the telomerase enzyme, which has profound importance in cancer and aging. Tetrahymena research also has shed light on general phenomena of biology including programmed genome rearrangements.Two organisms, a protozoan (Oxytricha trifallax) and the rhesus macaque (M......sight arose from the finding that an enzyme called telomerase elongates the telomeres of both reproductive cells and cancer cells and, as a result, extends the life span of these cells. In the current study, the scientists add another chapter to this story. Initially, they found that human cells made to overpr......Telomeric Repeat Amplification Protocol) to detect telomerase activity in cells taken from tissues and fluids of...tumors and none of 50 benign human tissues showing telomerase activity. A later review of all pre-1996 studies concluded that most malignant tumors were telomera...