Arsenic and old telomerase: Hopkins researchers unravel effects of arsenic on human cells
...t protects the ends of chromosomes. Low levels of telomerase cause end-to-end fusions of chromosomes, which pro.... "Once we saw the fused chromosomes we knew that telomerase might be responsible. So we did a very direct experiment that asked: Does arsenic inhibit telomeras...Enzyme increases number, size of heart muscle cells in mice
... mice genetically to continue producing the enzyme telomerase reverse transcriptase, or TERT, in heart muscle after birth. TERT enables the ends of the chromosomes, called telomeres, to be copied completely during cell division. Telomeres cap the ends of chromosomes, like plastic tips on shoelaces. Ordinarily, ...UCSF scientists halt tumor growth by manipulating telomerase enzyme
...er -- by creating just a miniscule mutation in the telomerase enzyme. The study, conducted in breast and prost...ells are much more sensitive to disruptions in the telomerase enzyme than had been thought. The finding hints, the researchers say, at a possible new strategy for...UT Southwestern researchers find another clue to secrets of cellular aging
...eater decrease in luciferase activity if they used telomerase to make the telomeres grow longer. "We knew that... Shay and Wright's earlier research has shown that telomerase causes human cells grown in the laboratory to retain their "youth" and continue to divide long past ...Three genetic steps convert normal mammary cells into breast cancer cells
...s chosen for use in this experiment SV40 large-T, telomerase hTERT and oncogenic H-rasV12 interfere with essential regulatory pathways governing cellular growth and survival. The sequential introduction of these three genes into HMECs results in cells that display the typical properties of malignant cells in...Study on chromosome ends may aid cancer research
...rch group reported. Researchers have been studying telomerase with great intensity for the past 15 years because...s age or become cancerous. Studies have shown that telomerase is present in 90 percent of cancer types, but is absent from most healthy cells. Cancer researchers ...Scientists issue telomerase caution
Cold Spring Harbor, NY -- The enzyme telomerase has received a great deal of attention since 1998 ...edures. Now, however, scientists report that using telomerase to extend the life-span of human tissue culture cells is associated with activation of the c-myc onc......ncisco researchers have discovered a region in the telomerase enzymethat they say could prove to be a target for... with each cycle of cell division. When activated, telomerase replenishes telomeres by copying the RNA folded within it into telomeric DNA and assembling it on th...Fox Chase Cancer Center molecular biologist named V Foundation Scholar
...ome shorter as we age. In most tumor cells, telomerase is active and telomere length is stabilized. The ...to contribute to human aging. Activation of telomerase and stabilization of telomeric DNA circumvents this restraint on cell growth and permits unlimited n...Scientists clarify much-sought enzyme, pave road to cancer therapy
Scientists worldwide have eagerly eyed the enzyme telomerase as an idealtarget for anti-cancer therapy. Active in cancer cells, which need it todivide, telomerase has sparked keen research. Biotech companies havepumped millions into finding a telomerase inhibito...Transformation of normal human cells into cancer cells
...ing of chromosomes during cell division. When the telomerase gene isswitched on, cells continue to grow and div...s turned on in mostcancer cells. But in mice, the telomerase gene is always on. "The next question we asked ourselves was whether telomerase is on in cancercel...UT Southwestern Researchers Find Way To Control Gene Activity, Opening Way For Cancer Drugs
... the PNAs tested thattargeted different regions of telomerase were able to inhibit the activity ofthe enzyme. In previous investigations by other scientists trying to usesynthetic bits of DNA to block gene activity, only about one in 10 or 20 wassimilarly successful. Beyond targeting telomerase, the study's fin......searchers at UC San Francisco have determined that telomerase - the enzymebrought to fame last year when scienti...il now, evidence has suggested that the ability of telomerase to extend thelife span of cells lay in its capacity to lengthen telomeres. In the current study, a c...Telomere Loss Spells Trouble for Aging Mice
...display an excess of telomeraseactivity suggesting telomerase might be involved in the cell becoming immortal.But the new findings indicate a lack of telomerase can also lead to cancer."These experiments have been to a certain extent mind-bending. No one would ...UCSF's Elizabeth Blackburn Receives Two Major Science Awards
...some cancers. Blackburn's discovery of the enzyme telomerase hasspawned a whole field of inquiry into the possibility that the enzyme could bemanipulated to prolong cell life and combat cancer. Blackburn received the California Scientist of the Year award from theCalifornia Science Center, a department of the ...Immortalizing Enzyme Does Not Make Human Cells Cancerous
... and immortalized bythe introduction of the enzyme telomerase are not transformed into cancer cells,perhaps clea...lleaguesdemonstrate that the cells with introduced telomerase do not produce tumors inmice. The fear that telomerase may cause cancer resulted because telome...First Derivation Of Human Embryonic Stem Cells Reported In Science
...rch and development. "Further, Gerons proprietary telomerase technology for prolonging the replicative lifespan...f human embryonic stem cells, and of telomeres and telomerase in cells -- fundamental biological platforms underlying cancer and other age-related degenerative di......ction. Duringeach round of replication, the enzyme telomerase is responsible for themaintenance of these chromos...omeres, and the properties,roles and expression of telomerase discusses the importance of telomeres and telomerase in cancer and ageing, aswell as in DNA repair ...Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...normal to cancerous growth. "The telomerase enzyme is an ideal target for chemotherapy because...t22 issue of Cell magazine. They report that this telomerase gene is expressedat high levels in primary human tumors (11 of 11 tumor samples studied,including 2 ...