Advances in tumor angiogenesis Dendritic cells co-opted to the dark side
...igh VEGF-A levels or when VEGF-A is inhibited, the tendency of dendritic cells to convert is reversed. "I think what is fascinating in terms of biology is the plasticity that this cell has depending on its microenvironment," says Benencia. It is well established that VEGF-A is the master switch for tumor ang...Molecular staples shape a cancer killer
...ity, and permitted the researchers to overcome the tendency of short peptides to lose their critical three-dimensional structure and their ability to kill cells -- when removed from the context of the complete protein. This has been one of the greatest obstacles associated with using short peptides as therap......an made chemical molecules, relying on the natural tendency of DNA strands to pair together like a zipper. Capitalizing on this, Liu is able to program the outcome of chemical reactions--before combining his raw materials, he attached each to a strand of DNA, attaching the ingredients he wants to react to com...