Chemicals used to protect soldiers in 1991 Gulf War can damage testes, animal studies show
...chemicals, caused the most severe deterioration in testicular structure and sperm production, and these conditio... see clear and well-defined damage to a variety of testicular structures." Abou Donia's team found the most pervasive cell damage within basal germ cells and spe...New study of healthy men finds semen quality decreases with age
...cluding age-related narrowing and sclerosis of the testicular tube, degeneration of germ cells, and normal changes in the prostate, or to increased probability of exposure to disease or environmental agents. "We considered time worked at Lawrence Livermore and occupational exposure in our study, and found no e...Human sperm may 'smell' their way to the egg, Science study suggests
...) for a previously undescribed odorant receptor in testicular tissue of humans. They cloned the receptor, expressed the receptor protein in a line of human embryonic kidney cells--an artificial expression system--and screened for potential ligands. Activation properties of these identified ligands were then tes...New immune-boosting cancer treatment shows promise
...pes of cancers affect the skin, prostate, ovarian, testicular and breast cancers, said Allison. According to Allison, CTLA-4 blockade could boost anti-cancer immune response to aid several kinds of therapies. "We have preliminary data indicating that the treatment can synergize not only with immunotherapy, but ...European Society of Human Reproduction & Embryology annual meeting
...yo research scientific and ethical Transplanting testicular tissue to restore fertility after chemotherapy Ectopic pregnancies are they linked to IVF and ICSI? Assisted reproduction in Europe latest figures to be announced Plus keynote presentations with latest findings from top international experts on ...JCI Table of Contents, 15 August 2003
...pable of inhibiting tumor cell growth in models of testicular and colon cancer, and that this correlates with the ability to inhibit Activin signaling. The study suggests that Cripto overexpression may play an early role in cancer progression through the inhibition of the tumor supressing effects of Activin. I...New pathway found to enhance cancer treatment
...r cells and slow tumor growth in experiments using testicular cancer cells. "Once RIP140 was removed, growth of cancer cells was repressed by retinoids at a faster rate compared to experiments where RIP140 was present," said Kristina White, who performed the experiments with Mark Yore, both graduate students in...UT Southwestern researchers learn importance of insulin family signaling in male sex determination
...t mutations in mice cause cryptorchidism impaired testicular descent a congenital abnormality affecting 2 percent to 3 percent of full-term human males at birth. Sex determination switches are diverse and can vary based on the presence of a Y or an X chromosome, environmental factors and social factors. Also,...Pesticide delays sexual maturation
... prevalence of congenital abnormalities related to testicular descent in the study group, but it was not statistically significant due to a small sample size. "Our study results suggest that endosulfan exposure may delay sexual maturity and interfere with hormone synthesis in male children," the study authors ......earch without it I would not be here today," said testicular cancer survivor and champion cyclist Lance Armstrong. "Other cancer survivors deserve the same opportunity to overcome the disease and live with a great quality of life. "It's clear that America can do more to help make progress against cancer," Arms...Other highlights in the January 21 issue of JNCI
...easures of fertility before diagnosis of germ-cell testicular cancer, Lorenzo Richiardi, Karolinska Institute, Stockholm, Sweden, et al. Retention of enrollees following a cancer diagnosis within health maintenance organizations in the Cancer Research Network, Terry S. Field, Meyers Primary Care Institute, et a...Transgenic animals produced using cultured sperm
... dish. These feeder cells, derived from zebrafish testicular cancer cell lines, promote the growth of spermatagonia and stimulate them to mature into functional sperm," said Dr. Sakai, the study's senior author and a reproductive biologist. One of the biggest advantages of the cultured sperm approach is that...Primate testes grafted into mice rapidly produce fertile sperm
...re that the entire process, from grafting immature testicular tissue to producing mature sperm, could occur during the life span of the host mice. Mature sperm, though, were produced in the grafts in as little as 7 months. In the experiment, donor tissue from the testes of two 13-month-old rhesus monkeys was gr...Cancer rates in teens and early 20s rising
...ymphoma, melanoma and germ cell tumours, including testicular germ cell tumours. A news briefing at Teenage Cancer Trust's Third International Conference on Adolescent Cancer today (Monday 1 March) was told that although cancer is still rare in this age group around 1,500 cases a year in England it is the le...... sperm counts and thus male fertility. The rise in testicular cancer and male genital deformities has also been discussed in connection with phthalate exposure. The researchers from Erlangen have demonstrated that humans are exposed to phthalates in far greater quantities than had been previously believed. In s......after the father had been successfully treated for testicular cancer with surgery, radiotherapy and chemotherapy between 1979 and 1981. Following diagnosis at the age of 17 but before treatment, which was to leave him sterile, five ampoules of sperm were frozen. Long term storage continued until he married and...