Tag: "therapies" at biology news

NIH awards $18.2m to The Burnham Institute to develop Center on Proteolytic Pathways

...standing this process is critical to designing new therapies based on promoting or inhibiting cellular behaviors. A particular strength of the Center is its emphasis on the use of activity-based proteomics to profile protease function. This approach, developed by Dr. Bogyo at Stanford, marks an innovation ove...

Phase II trials of second-generation antisense cancer drug planned following successful early study

...to see benefits akin to some of the other targeted therapies now in use."...

Researchers identify protein promoting vascular tumor growth

...es to the vascular tumor site. This means that therapies to eliminate the MCP-1 protein could be a key to h... A new treatment option is needed because current therapies including steroids and alpha interferon have a number of high-risk side effects. Steroids suppress...

UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies

... the synthetic molecules also may lead to new drug therapies with improved treatment options. The researchers u...achievement, he added, would be the development of therapies using smaller molecules, which can often be used in oral medications. Therapies that rely on larger ...

Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival

...That could help physicians determine how to modify therapies to improve chances of success in the future. The findings were based on a retrospective study of samples taken from osteosarcoma tumors of children treated at St. Jude during a 20-year period. Telomerase is an enzyme that helps cancer cells survive ...

Targeted therapy knocks out pediatric brain cancer in mice

...ding is encouraging in that such precise, targeted therapies may someday replace traditional treatments that can have overwhelmingly negative side effects for pediatric cancer patients. The research is published in the September issue of Cancer Cell. "Therapy for pediatric cancers of the central nervous system...

New way to protect brain from stroke damage

...racteristic of stroke. The results may lead to new therapies designed to avert the often debilitating effects of stroke, for which successful treatments are currently lacking, the researchers said. A series of experiments in laboratory dishes and in animals implicates a recently described class of membrane ion...

Gene expression in liver tumors and patient prognosis

... open the door to the development of more targeted therapies for liver cancer patients. While gene techno...of each subclass could be useful in developing new therapies for liver cancer patients. "Even if a curative therapy for HCC patients cannot be offered at this...

IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth

...nceptual framework for considering anti-angiogenic therapies for IBD as is currently ongoing in other autoimmune disorders."...

Columbia research to examine gene influence on severity of peridontal disease, therapy response

...s, and will allow the development of pharmacologic therapies targeted specifically to a person's own genetic predisposition for response. A new three-year, $1.8 million grant from the National Institute of Dental & Craniofacial Research will support research to determine whether different forms of periodontit...

Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University

...tokines, PLA2 and eicosanoids). "While current IBD therapies usually address a single, presumably central, inflammatory mediator," the researchers said, "growing evidence shows that tissue injury involves the synergism of a number of mediators." They suggest that "MFAIDs control the production of a host of inf...

Charting the future in prostate cancer care: A call to action

...ll be compelled to join the war. The need for new therapies is great, and since 1993, The Prostate Cancer Foundation has played a pivotal role in supporting and funding R&D breakthroughs to defeat this disease. The timing is becoming ever more critical. As the baby boomer men reach the target age for prostat...

Genuine stem cells found in skin might treat hair loss, wounds

...lenishing cells, scientists hope to advance on new therapies designed to repair or replace damaged tissues and organs, said the researchers. In mammalian skin, each hair follicle contains a reservoir of stem cells, known as the bulge, which can be mobilized to regenerate the new follicle with each hair cycle a...

Small, Smac-like molecule encourages death of cancer cells

...a finding that could lead to more effective cancer therapies with fewer side effects. In the Sept. 3 issue of t...all- molecule Smac mimic. The challenge for cancer therapies now is that they also tend to kill normally growing cells as well as cancer cells, which results in ...

Scientists discover proteins involved in spread of HIV-1 infection

...ins they interact with could lead to potential new therapies for HIV-1 as well as other viruses that use the same budding mechanism. The research appears as the "Paper of the Week" in the August 20 issue of the Journal of Biological Chemistry , an American Society for Biochemistry and Molecular Biology jou...

MIT team explains yin-yang of ginseng

...le of why we need regulations standardizing herbal therapies through compositional analysis," said Professor Ram Sasisekharan of MIT's Biological Engineering Division. With the new results, "we can now rationally isolate the components to focus on a specific effect, such as promoting blood-vessel formation." I...

The future of HIV therapeutics is brightening, according to Gladstone Institutes Director

...ncoding 15 proteins, are leading to compelling new therapies that deny the initial entry of HIV into its cellular host. In addition, fast-moving research of naturally occurring factors with potent antiviral properties is opening the way for future development of an entirely new class of anti-HIV drugs. New age...

Bright idea could doom cancer and viruses, say Purdue scientists

...ay someday find themselves blinded by the light of therapies based on recent Purdue University chemistry resear... activated by light of a specific frequency. While therapies based on the discovery are likely many years away, the compounds could have potential as anticancer ...

Tiny molecules have big potential as cancer drugs, Stanford researcher believes

PHILADELPHIA Many cancer therapies take a "big stick" approach, targeting rapidly dividing cells in the body to stop malignancies in their tracks but often triggering horrible side effects in the process. New research from the Stanford University School of Medicine points toward the p...

OneWorld Health compiles comprehensive state of infectious diarrhea treatments, potential solutions

...o approved drugs for children with diarrhea. Most therapies today target the adult travelers' market with little consideration for pediatric use. Some vaccines focus on one pathogen, such as rotavirus, although there are multiple causative pathogens. Efforts are also underway to prevent exposure to the patho...

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