Key stimulator of colorectal cancer identified
... the risk of CRC. However, the exact mechanisms of this protective action are unclear. PGE2 is a metabolit...number and size of intestinal polyps. Importantly, this effect of PGE2 was not observed in these mice when they lack PPARd. "Our results identify PPARd a...Scientists decipher genetic code of biothreat pathogen
...stability may explain why some scientists consider this to be the ultimate bacterial pathogen," says Willi...yet to develop a vaccine that is effective against this highly infectious equine disease. When humans are infected, treatment requires a long-term regimen o...Prion propagation: Avoiding the toxic oligomer
...proteins form amyloids, have also been seen during this process, some of them near NM fiber ends. ...tion of monomers, Weissman and colleagues explain, this finding could not be explained by a simple model of nucleation polymerization, in which growth occur...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...cancer cells in which NF-kB was inhibited, seen in this study, since previous experiments have shown that high doses of TNFα can kill tumor cells when NF-kB activity is inhibited. However, further experiments proved otherwise. When inflammation-inducing LPS was administered to tumor-bearing m...Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
... unknown wether deletions of d-catenin would alter this process. In the new work, researchers Inbal Israe...se synaptic and cognitive dysfunction. Ultimately, this work may facilitate the understanding of the mental retardation observed in Cri-du-Chat Syndrome and...Amyloid fibers sprout one step at a time
...s Alzheimer's and Parkinson's. The researchers say this may have important implications for those designin...gation of amyloid protein, said Weissman. Studying this process could have important implications for understanding amyloid diseases, he said. Initial effo...Chemical genetics identifies SARS inhibitors
... tackle emerging and existing diseases. Crucially, this study has provided a reservoir of novel biologically active small molecules that could be developed as anti-SARS therapeutics....Resveratrol synthase uncovered: Cyclization specificity of type III polyketide synthases
...rate the same tetraketide, but STS enzymes cyclize this tetraketide via an intramolecular C2 to C7 aldol c...vealed the structural basis for the specificity of this critical reaction. To do this, the Noel group generated the first crystal structure of a STS and ide...Students build submarine to track Octopuses
...find out more about the Giant Pacific Octopus, but this elusive creature doesn't willingly reveal its secr...er universities, are building a mini-sub to answer this need. In July, they took a prototype to Alaska for testing. Appropriately named Shadow III -- and pa...Brown ecologist garners major National Science Foundation grant
...rent climates affect genes in a single species in this case, an annual weed in the mustard family. The Eu...y. Researchers will use genomic tools to study how this plant combines information from a variety of seasonal signals, such as day length and temperature, t...22nd amino acid synthesized and added to genetic code of e. coli bacteria
...bed in two papers published in scientific journals this month. The first appeared in the British journal N...up provided Kyzycki's group with a small amount of this chemically synthesized pyrrolysine. "The sample that Michael's team produced was exactly what the ch...Algal contact as a trigger for coral disease
...k, Seabra and Bak demonstrate a sinister aspect of this competition. One of the most common macroalgae, Ha...ribbean, a large number of coral colonies on which this alga was transplanted developed white plague whereas unexposed colonies did not. In addition, the pl...Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
In research reported this month in The Plant Cell, scientists succeeded in p...utrition and the environment. In research reported this month in The Plant Cell, Ernst Heinz at theUniversity of Hamburg (Germany) and colleagues succeeded ...New sign language suggests children create language's fundamentals through learning
...s. Researchers studying these similarities suggest this week in Science that, in fact, children give lan... into independent elements. And it so happens that this is what we see in language after language," Senghas said. Thus, parents may not need to worry too mu...US investment firm gives away Rhode Island-sized lands in Chile
...eld." A Unique Alliance To assure continuity in this important project, Goldman Sachs, the Goldman Sach...reserve and protect the key ecological features of this land for the people of Chile. The transfer represents one of the most significant gifts of private l...K-State, other universities to study how climate affects plant evolution
...king with some of the premier labs in the world on this project, which is being funded by the National Sci...uce successfully, Welch said. Plants' abilities in this regard illustrate an important capacity of many biological systems: the ability to assess multiple s...The American Phytopathological Society announces 2004 awards
...ao, University of California-Davis. Syngenta gives this award to an APS member for an outstanding recent contribution to teaching, research, or extension in plant pathology. ...Information system to help scientists analyze mechanisms of social behavior
...ces. "We are putting significant resources behind this project to ensure that it demonstrates the great potential of genomic biology." New genome technology will underlie the BeeSpace efforts in biology and informatics research. "In biology research, we will develop the first complete analysis of the nor...Tips from the Journals of the American Society for Microbiology
...ngivitis. "The results of this study have shown that the three pathogens can be detected in the plaque of children with and without gingivitis and specifically that T. forsythensis is associated with dental plaque found at sites without gingivitis," say the researchers. "Further ......l make a better robot, but that is not the goal of this program." Full has studied animal locomotio...d the phrase "neuromechanical systems biology" for this multidisciplinary approach, which integrates data across mathematical models, numerical simulations,...