Tag: "thymus" at biology news
Autoimmunity Gene Discovered
...CED gene product are specifically expressed in the thymus
and in other immunological tissues is still disputable. It is however likely that the APECED gene and its product are taking part in a chain of biological events that regulate immune response. The APECED gene is the first gene which...
HIV Infected Adults In UCSF Study Show Evidence Of Thymus Activity
Contrary to the widely held belief that the thymus
-- an organ essential forproducing competent immun...in the patient's blood,regardless of age: a larger thymus
meant more T cells. All but one of thepatients under 40 who were in the early stages of HIV disease ...
Researchers Discover How The Immune System Shuts Down Faulty T Cells
...m the bone marrow, they enter thethymus gland. The thymus
identifies promising infection fighters by selecti...body's own peptides, presented byMHC proteins. The thymus
then eliminates those cells that bind self antigen tootightly, to prevent autoimmune reactions. At t...
Scientists say vitamin C may alleviate the body's response to stress
...he adrenal glands, andreduction in the size of the thymus
gland and the spleen, according to Campbell. In addition, the vitamin C treatment elevated the levels of circulating IgGantibody, the body's principal defense against systemic infection, he said. In the control group-rats who were not subjected...
Disconnecting molecular handbrakes has drastic consequences
...ne regulates the differentiation of T cells in the thymus
and affects theaction of those cells elsewhere in the body. The data from the experiments indicated that SOCS1 performed threefunctions, said Ihle. "In the thymus, the gene probably plays a major role inthe differentiation of T cells," he said. "A...
Researchers at Children's Hospital of Philadelphia play major role in genetic milestone - first
full sequencing of a human chromosome
...ft palate, feeding problems, an abnormal or absent thymus
gland, and learningdisabilities. In 1992, Dr. Emanuel's laboratory was the first to develop a blood test to detect thesyndrome, which is caused by a deletion or loss of genetic material on the chromosome, and whichoccurs in as many as 1 in 4,000 birt...
Protein found in yeast and humans appears to play a key role in regulating cell growth
... throughout the body. "If you were looking at the thymus
or the liver, for example, and wanted to distinguish cells that were doing normal things vs. cells that have lost control and gone haywire, the activity of this protein may be a very sensitive indicator of the uncontrolled cell growth characteristic ...
DNA details suggest how human chromosomes break, rearrange and cause a genetic disease
...fects, cleft palate, feeding problems, an abnormal thymus
gland and learning disabilities, is the flip side of the coin from the +der(22) syndrome. "Children with deletion syndrome are lacking important genes, while those with +der(22) syndrome have an extra copy of these and other genes," said Dr. Emanuel....
Transplanted human stem cells develop into broad range of tissues, persist over a year in research at The Children's Hospital of Philadelphia
...keletal muscle, heart muscle, bone, cartilage, the thymus
gland and stroma, which is supporting structure for bone marrow. Furthermore, transplanted human MSCs were found at the site of clipped tails in the sheep, suggesting that those cells were involved in wound healing. MSC transplants may have a futur...
Contract bridge enhances the immune system, according to a preliminary study by researchers at UC Berkeley
...ge stimulates the immune system, in particular the thymus
gland that produces white blood cells called T cel...nt. T cells are white blood cells produced by the thymus
gland and sent out to patrol the body in search of viruses and other invaders. T cells that sport a ...
UCSF study of HIV patients identifies interleukin-7 as a key factor in controlling T-cells
...isease fighting white blood cells derived from the thymus
that are essential for a healthy immune system. I...e the production of IL-7; IL-7 then stimulates the thymus
and other immune tissues to produce T-cells in an attempt to restore T-cells to their proper level. ...
Gene for DiGeorge Syndrome discovered
...ng structural heart defects and the absence of the thymus
and parathyroid glands. Some infants must have corrective heart surgery in the first days of life. Infections, seizures and facial abnormalities, especially of the jaw, also are seen. Many of those diagnosed with DiGeorge Syndrome suffer from borderl...
Watching clonal deletion in action
... limited to proteins that are expressed within the thymus
and can be presented to developing T cells, largely by thymic dendritic cells (DCs) or macrophages. Hence, it is not surprising that many autoantigens are proteins with limited distribution, for which this mechanism of central tolerance cannot be us...
New molecular key to disposal of dying cells
...udy led by Rona S. Scott, PhD, of Matushima's lab, thymus
cells that had been made apoptotic by treatment with the corticosteroid dexamethasone were placed in culture dishes with macrophages taken from the knockout mice and normal mice. After about an hour in the dishes, it was clear that macrophages from n...
Gene that directs fate of many embryonic stem cells identified
... cells and tissues, including the pancreas, liver, thymus
and thyroid. "Exploiting this master gene, we can control stem cell differentiation from the inside, as opposed to trying to boost differentiation from the outside with growth factors," said Didier Stainier, PhD, UCSF associate professor of biochemis...
In groundbreaking research, Yale and Salk Institute scientists reveal the structure of a key component that makes cells move
...ies of highly purified Arp2/3 complex from the cow thymus
gland. They discovered that this preparation forms crystals suitable for x-ray crystallography....
Antimicrobial peptides: new weapons to fight infection
...ite effectively without the help of lymphocytes, a thymus
or antibodies. Multicellular organisms live, by and large, harmoniously with microbes. The cornea of the eye of an animal is almost always free of signs of infection. The insect flourishes without lymphocytes or antibodies. A plant seed germinates su...
UT Southwestern researchers discover how common MS drug slows progression of the disease
...in type of T cell in MS patients. Produced by the thymus
gland, T cells are white blood cells that fight infection and, in healthy people, coordinate the bodys immune response. There are two types of T cells, CD4 and CD8 cells. Both are involved in the immune process that underlies MS and, in MS patients, ...
Promoting wound repair
...ough gamma-delta T cells are the first T cells the thymus
produces, this organ nearly shuts off production of them later in development. Throughout life, the body maintains its population of gamma-delta T cells "on-site," allowing them to divide as needed. In the epidermis where the gamma-delta T cells are ...
Gene linked to type 1 diabetes
...s T cells, that leave the marrow and travel to the thymus
for filtering and processing. The thymus
filters and rejects T cells that would harm the body. In a process that is less understood, a health...