Prion propagation: Avoiding the toxic oligomer
...ization progress. Initially, fiber growth rate was tied to the concentration of NM monomers; but as concentrations increased, growth rate was moderated by NM conformational changes caused after binding to the fiber ends. Shaking the samples increased polymerization rate. During polymerization reactions, ...Israeli scientists reveal the plan of a key cellular machine
... from its DNA template. Many diseases appear to be tied to mistakes in this process, and understanding the workings of the machinery involved may lead to the ability to correct or prevent them in the future. Since the discovery, around 25 years ago, that the bits of DNA in the genes that code for protein...Study by Israeli scientists provides insight on DNA code
... from its DNA template. Many diseases appear to be tied to mistakes in this process, and understanding the workings of the machinery involved may lead to the ability to correct or prevent them in the future. Since the discovery, around 25 years ago, that the bits of DNA in the genes that code for protein...Newborns have ear preferences, too
...said. "These stimulus-related differences that are tied to the different sides of the brain have never been found at such a low level of the auditory system before." Their findings suggest that at early stages of auditory system development, the cochlea and brainstem process sound. The cochlea, a spiral...Last of known genes identified in complex obesity syndrome
...s the first member of its larger gene family to be tied to any disease," says Katsanis. "While not much is known about ARL6 specifically, we know quite a bit about its relatives, so we know which regions of ARL6 are crucial for the protein's correct function. The mutations in these families wouldn't let t...8 environmental stewards win $900,000 in biodiversity awards
..., to be spread over three years. Three others were tied for a Leadership Award and receive US$60,000 each. The awards recognize previous and potential excellence. Winners may use their awards in any way they like, though all winners so far have plowed their funds back into biodiversity projects. There is...Misfiring proteins tied to inflammation and sick feeling of type 2 diabetics
...ences, is pursuing the theory that inflammation is tied to a disturbance of signal-carrying cytokines. Type 2 diabetes -- once considered an adult-onset disease -- is an increasing problem alongside obesity, even among teenagers. Some 18 million Americans suffer from diabetes, with more than 90 percent b...Geologists discover water cuts through rock at surprising speed
... and was prompted more by regional climate changes tied to the last ice age than by water pouring from melting glacial ice. "The period of incision we measured correlates with a period of cold and stormy climate during the last glacial period that is also recorded in ice cores drilled into the Gre...Climate may play role in lynx's hunting ability
... regions of the country and those differences were tied to large-scale climatic patterns. "The genetics of the lynx are quite different among these Canadian regions and we questioned whether there was some sort of barrier that might stop gene flow," said Boutin, a biologist with the Faculty of Science. "...New insight into cancer metastasis
...is probably the first gene regulator that has been tied so definitively to human cancer metastasis," says Yang. Andrea Richardson, a pathologist at Brigham and Women's Hospital and coauthor on the paper, correlated these finding with her lab's data taken from human breast cancer studies--ess...Myths surrounding Cuyahoga River fire 35 years ago
...aste into the waterway. Cleveland's hands had been tied where state laws overrode local authority and did not allow the city to take action against the polluters.The federal government had the River and Harbors Act of 1899 to grapple with pollution, but the general focus of the law was to keep waterways n......ts have the Mus81 mutation. If the mutation can be tied to human tumour formation, it should allow people who test positive for such a gene mutation to monitor their health more closely, since they would be at high risk of developing cancer. In addition, a grant from the National Cancer Institute of Canad......ons such as soot, while non-absorbing aerosols are tied to cooling, which scientists call "negative forcing." "In the long term, greenhouse gas effects are not going to be masked by aerosols," Penner said, debunking a popular myth related to climate change. "But in the short term, we have a problem predic...Continents played key role in collapse and regeneration of Earth's early greenhouse, geologists say
...t was locked into this crust was essentially lost, tied up for the 60 million years or so that it took the minerals to get recycled back to the surface or outgassed through volcanoes. The hot early atmosphere probably contained methane too, Lowe says. As carbon dioxide levels fell due to weatherin...Mite transmits viruses damaging to wheat
...ons. For example, what if the problem cannot be tied completely to the mite, but rests with an abundance of over-summering grasses that might be harboring the viruses? "Again, we just don't know until more work is completed," said Rush. Rush and Michels are delving deeper into the environme...Cancer drug resistance research leads to possible therapeutic target for Alzheimer's disease
...or to oxidative stress response. This observation tied in with metabolism of free radicals and of beta-amyloid, a primary component of Alzheimer's disease plaques, consisting of dense deposits of protein and cellular material. According to Tew, ABCA2 can play a role in cholesterol transport and also in m...Field Museum gives Parker/Gentry Award to Chinese conservationist
...ples, whose culture and heritage have been closely tied to the land for hundreds of years, would lose their way-of-life if the Nu dams were built. Other dam projects around the world have endangered, displaced or destroyed communities. The RBI surveyed ethnic minorities living near the Nu, including the ...From algae, weeds and people: new genetic clues to complex obesity syndrome
...al BBS genes, and it likely includes genes already tied to other diseases and conditions whose traits overlap BBS," says Katsanis. The cellular problems behind BBS, a rare condition, may also be involved in some "regular" or non-syndromic instances of BBS traits, such as specific learning disabilities, un...Biologists uncover genetic links to broad range of human disorders resulting from cilia dysfunctions
...omplex and broad, the disorders were not initially tied to cilia dysfunctions," says Zuker. "These people ...ies that sought to identify one or two human genes tied to a specific human cilia dysfunction, Zuker's team started with the entire genomes of a wide range ...Tropical legume could be alternative hay/forage crop for Texas
...ntal nitrogen. The price of nitrogen fertilizers, tied to the costs of oil and natural gas, is rising. So an alternative high-protein forage legume such as lablab could make sense both economically and environmentally, Smith said. More importantly, there's also the possibility of it becoming a value-add...