Molecular motor implicated in tissue remodeling
...digesting collagen, enzymes such as MMP-1 initiate tissue remodeling, which can have a variety of purposes from organ development to tissue repair to metastatic invasion of tumors," says senior author Gregory Goldberg, Ph.D., professor of d...Belgian researchers explore revolutionary approach to angiogenesis
...essels). Equivalent sized blood vessels in healthy tissue can't do this. "What this means is that we may hav...ncreased blood flow to the tumour but that healthy tissue was not affected. We were then also able demonstrate that administering BQ123 could significantly in...Researchers find color sensitive atomic switch in bacteria
...ins are the most accessible targets to treat human tissue or destroy infectious microbes, he said. More than 60 percent of medications target membrane proteins on human cells and many antibiotics target membranes on pathogens....Safety of isoflavones in dietary supplements targeted by Illinois initiative
...research on the effects of phytoestrogens on brain tissue and cognitive function, including cognitive flexib...pted to changes in hormone responsiveness, adipose tissue and the brain. ...Phase II trials of second-generation antisense cancer drug planned following successful early study
...n earlier ones in that the molecules have a longer tissue half life and are potentially more potent. Pre-clinical studies had shown that blocking the production of clusterin with OGX-011 impairs a cancer cell's survival mechanism and enhances the effectiveness of standard chemotherapy, radiation and hormone...Award winning researchers reveal potential new role for Glivec
...ctly the FNAB objectives supporting research using tissue sample biopsy for molecular analysis to select more accurately patients who could benefit from targeted therapeutics. We are confident that this approach will first benefit patients by tailoring their treatments and avoiding unnecessary therapy and o...Trial shows which brain cancer patients benefit from temozolomide
...days, although the availability and quality of the tissue is an important issue. If implemented widely it would mean that temozolomide would become a targeted treatment. Dr. Monika Hegi told the EORTC-NCI-AACR[1] Symposium on Molecular Targets and Cancer Therapeutics in Geneva today (Wednesday 29 September)......the opportunities arising from stem cell research, tissue engineering research and device miniaturisation. R...eranostics), and to design systems able to promote tissue regeneration and repair (in disease, trauma, and during ageing) without the need for chemotherapy. T...Evidence builds for potential new cancer drug target
...ientists to delete c-myb from one specific type of tissue in the model rather than from the entire organism. "We removed the c-myb gene from T cells and in the process discovered that c-myb is required for white blood cell formation," said Reddy. In other research conducted by the team but not yet publishe...Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
...tors from around the world have shown that adipose tissue is a rich source of autologous regenerative cells.... bone marrow, skeletal muscle, embryonic and fetal tissue and rarer sources of stem cells. Additionally, regenerative cells from a patient's own adipose tissu...DNA barcode finds four new bird species
...ifying species. It requires only a small sample of tissue so that wildlife biologists could use it to identify the stomach contents of animals and reconstruct food cycles. Other uses include identifying birds that fly into airplane engines and testing for protected fish species, for example, that sometimes ...No role for simian virus 40 in human pleural mesotheliomas
...e assays were not derived from genuine SV40 in the tissue samples but from SV40 DNA fragments engineered int...s searched for SV40 DNA, RNA, or protein in frozen tissue samples from 71 human pleural mesotheliomas. According to the study, the methodology used by most re...16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
...er reveals potential new role for Glivec in a soft tissue cancer Chairman: Professor Jaap Verweij (EORTC chairman of conference scientific committee) together with scientific committee co-chairmen Dr Janet Dancey (NCI) and Dr Eric K Rowinsky (AACR) NB: any reports involving the topics outlined above are ...Yale digital diagnostic technology is basis of new company, HistoRx Inc.
...s researchers to localize and quantify proteins in tissue while maintaining spatial relationships -- a proce...o holds exclusive license to databases from Yale's tissue archive containing 20- to 40-year clinical follow up information corresponding to different types of...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...-induced tumor growth, the team studied mouse lung tissue as well as tumor nodules for expression of specific proteins known to modulate the body's normal cell-killing process. Death-inhibiting proteins were abundant in tumors formed by cancer cells with normal NF-kB, but were absent in the tumors formed b...New way to protect brain from stroke damage
...the location of the obstruction and how much brain tissue is affected. The new work identifies a mechanism whereby acidic brain conditions following ischemia spur a portion of the damage. The normal brain requires complete oxidation of glucose to fulfill its energy requirements, the researchers explained. D...JCI table of contents September 15, 2004
...al vasculature and its associated retinal neuronal tissue should be considered together when developing potential treatments for delaying or preventing retinal degeneration. An accompanying commentary by Lois Smith, of the Children's Hospital in Boston, discusses the effect of stem cells transplantation on ...European common frog found to use novel mating strategy
...ars in the field observing this behavior, and took tissue samples to test the paternity of the eggs in numer...es, Vieites gathered 16 separate clutches and took tissue samples from the original parents and the pirates. With colleagues at the University of Konstanz, Ge...Simian virus 40 not associated with non-Hodgkin lymphoma, study shows
...roups have reported detection of SV40 in the tumor tissue of 15% to 43% of NHL patients, and the virus causes leukemia and lymphoma in laboratory rodents. However, other research groups did not detect SV40 in NHL tumors, and recent evidence has suggested that it cannot infect human lymphocytes. Moreover, ep......s provided researchers a new glimpse inside living tissue and cells that other biomedical imaging methods ca...s around the magnet, revealing chemical spectra in tissue up to 10 times the resolution seen in stationary NMR. But it's living tissue that holds the most pr...