Duke Researchers Discover Central Role Of Nitric Oxide In Hemoglobin Action
...nsumes NO. Adding these bits of knowledge together -- that NO keeps vessels open,but that hemoglobin destroys NO -- produced a major paradox that no onecould solve, Stamler said. How can blood vessels maintain a constant pressurewhen the hemoglobin that flows through them destroys NO on contact? ...Enzyme's "Magic" May Hold Key to Anticancer and Antimicrobial Drugs
...o the central hole and the C' domains join together (4). The B' domain in front is transparent in (4) to permit visualization of the DNA behind it. The structure in brackets is a hypothetical intermediate. Many drugs that target topoisomerase II stabilize such an interm...Computer Program For Quicker, More Detailed Mapping
...gnpostsin the human genome. Markers that are close together remain on the samepiece of DNA when scientists cut the long strands into small pieces. Usingstatistics to count how often particular pairs of markers remain together,computers can measure the distances between them and can determine theirorder on the...Children Become Gorillas In VR Zoo
...ed."With the help of Georgia Tech, we hope to work together to expand thisproject so that the 'virtual zoo' will one day be a reality." To make the project an effective teaching tool, researchers workedhard to make both the virtual environment and the virtual apes asrealistic as possible, said Hodges, an ass...Duke Researchers Show "Editing" Can Fix Faulty Genes In New Approach To Gene Therapy
...ibozymes" to cut junk out of mRNA and paste itback together again. Sullenger reasoned that ribozymes could be adapted as atool to recognize defective mRNA and splice in a corrected version. To accomplishthis, he turned to the first ribozyme discovered, from the single-celledorganism Tetrahymena thermophila ...Duke Researchers Find Second Gene Linked To Blood Vessel Disorder
...o genes now described, Marchuk will begin to piece together whatendoglin and ALK1 are doing, whether they interact with each other, andhow each normally contributes to the ability of blood vessels to heal inresponse to injury. While a treatment based on Marchuk's work may be some years down the road,he emph...Honeybees In The Wild Nearly Gone In North America
...er10 to 20 times the number of bees that were ever together before,we could expect to have disease outbreaks and other challengesoccur. We can't just whimsically switch to different bees andhave that solve all the problems."...Core Spins Faster Than Earth, Scientists Find
... diameter of 1,500 miles.(The inner and outer core together are 4,350 miles wide and theEarth's diameter is about 7,900 miles.) The electrical currentsand convecting movements within the Earth's liquid core generatethe planet's powerful magnetic field, which in turn drives theinner core in the way that can no...Nitric Oxide May Hold Key To First Treatment For Deadly Form Of Malaria, Duke Scientists Report
...sible therapeutic uses." The finding ties together the mountains of scientific studies in recentyears linking NO with everything from blood vessel dilation to neurotransmissionin the brain to intestinal contraction to penile erection. "Virtuallyeverywhere scientists look in the body, they find NO has...Nitric Oxide Found To Control Cells By Turning On Genes; Suggests New Role In Health And Disease
...sible therapeutic uses." The finding ties together the mountains of scientific studies in recentyears linking NO with everything from blood vessel dilation to neurotransmissionin the brain to intestinal contraction to penile erection. "Virtuallyeverywhere scientists look in the body, they find NO has...Duke Primate Center Sets October Expedition To Find 'Juliet'
...rsall's, sifaka. Thethree animals have been living together in harmony, said Simons. "Clearly, Romeo is a very lively, playful animal, with his own friendlypersonality," he said. "We see no reason why he wouldn't attachvery quickly to a young female of his own kind and make a good father. Interms of our nami...Newly Discovered Gene Halts Cell Division and May Have Cancer Link
..., each pair of the duplicated chromosomes is bound together at structures, called centromeres, that fit around each chromosome like a napkin ring. In order for a cell to divide, thread-like fibers must attach to each centromere and pull the chromosomes apart. That's where the MAD2 gene comes in. The research...Two Long-sought Diabetes Gene Found
...gland, and the Institute Pasteur de Lille, France, together with other investigators from Denmark, Japan and the United Kingdom, in back-to-back papers in the December 5 issue of Nature. Both genes evaded scrutiny for years because neither was thought to be involved in the control of blood glucose levels. But...Fast Measurement Technique Reveals Early Steps In Protein Folding
...er time, we can tell how the amino acids arecoming together and how different parts of the protein are moving around." Based on recent measurements of apomyoglobin, Gruebele has identified twodistinct phases in the folding process. In the first phase, which lastsseveral hundred nanoseconds, the amino acids q...New Sensor Provides First Instant Test For Toxic E. coli Organism
...mbranes. Exposure to UV light links the molecules together by activating atriple bond within the diacetylene lipids, creating a blue-tintedpolydiacetylene (PDA) film. PDA films are sensitive to changes on their surfaceas manifested by the wavelength of light they transmit. When E. coli 0157:H7toxins bind to...Scientists Identify Gene For Sexual Behavior In Male Flies
...tempts to mate. Part of a group of genes that work together to govern all aspects ofsex in these flies, including development of male and female organs. At work in a very small fraction of the cells in the fly's brain.The properties of the fru gene's target neurons suggest that theycarry out command-and-con...A Sensor, A Switch, A Zipper: Protein Engineers Design Potential Tool
...ate genes or as a molecular zipper to join together proteins. The newly designed structure i...ns together. In nature, coiled coils "zip" together two or more subunits of a protein. To take advantage of this functionality, scientists would...ORNL Microscope "Sees" Bumps That Reveal Partial DNA Structure
...o longchains of deoxyribose sugar molecules hooked together by phosphate groupsand twisted into a double helix, not unlike a spiral staircase. The work was done by Dave Allison and Mitch Doktycz, both of ORNL'sMolecular Imaging Group, which is headed by Bruce Warmack. The group is inthe Health Sciences Resear...Researchers Corral Millions Of Microscopic Membranes
...ided to leave Stanford. Boxer got Ulman and Groves together and they came up with the idea of using microfabrication techniques to make smaller membrane corrals. "The hardest part was deciding what to do," Ulman said. The actual processing involved was straightforward. But, because electrical engineers have n......logical diversity. The Lab and Cornell University together provide an international center for training both amateurs and professionals in the ecology, evolutionary biology and conservation of birds....