Study confirms safety and tolerability of zaleplon for long-term treatment of insomnia
...omnia. Previous studies have proven thesafety and tolerability of zaleplon for short-term use (up to four weeks) ...lso seen in double-blind studies ofzaleplon, where tolerability has been similar to placebo. Zaleplon is a non-benzodiazepine, the first in a new chemical c...Targeted genetics presents promising data from cystic fibrosis clinical trial
...e I dose-escalation study evaluated the safety and tolerability of tgAAV-CF delivered via nebulizer to 12 patients age 19-41 (median age 29) with mild CF lung disease. All patients in the study had FEV1 levels (a standard measure of lung function) at least 60% of normal. Doses of 1010, 1011, 1012 and 1013 DNAse ......, and the skin was assessed to determine the local tolerability of the patches. Overall, the results showed that testosterone levels increased to within normal ranges and was well tolerated. Treatment with the higher dose of testosterone improved sexual function and psychological well-being substantially more th......, Calif.) A clinical trial testing the safety and tolerability of two investigational AIDS vaccines for healthy i...trial, the UC Davis study will test the safety and tolerability of genetically engineered vaccines that have been designed to protect the body against HIV infection...Phase 3 psoriatic arthritis data for ENBREL (etanercept) announced at a national scientific meeting
...placebo-controlled study assessed the efficacy and tolerability of ENBREL (25-mg twice-weekly subcutaneous injections) or placebo in 205 patients with psoriatic arthritis. The primary endpoint was measured by the proportion of patients who met the American College of Rheumatology preliminary criteria for improve...New study shows vagus nerve stimulation effective for treatment of children with refractory epilepsy
...Neurology. The study evaluated the effectiveness, tolerability and safety of VNS therapy for children after three months and six months of use in the largest reported group of children to receive VNS. The study found that VNS therapy was safe, well tolerated and highly effective in reducing the frequency of sei......opean study was undertaken to evaluate the safety, tolerability and antiviral activity of six different dose levels of omega interferon in previously untreated patients with chronic hepatitis C. In this open-label study patients were treated for 3-12 months. All major HCV genotypes were present. Antiviral acti...Durable responses reported with Bexxar
...o be delivered to each patient and may enhance the tolerability of the treatment....ENBREL is first therapy approved for psoriatic arthritis
...controlled phase 3 study assessed the efficacy and tolerability of ENBREL (25-mg twice-weekly subcutaneous injections) or placebo in 205 patients with psoriatic arthritis. The primary endpoint was measured by the proportion of patients who met the American College of Rheumatology preliminary criteria for improve...Fosrenol (TM) reduces damaging high levels of phosphate in end-stage kidney disease patients
...months to collect more long-term effectiveness and tolerability data. During Finn's trial, side effects that occur...effects including hypercalcemia, bone toxicity and tolerability problems....First study to show the potential for effective prevention of migraine with an AT1 receptor blocker
...ortantly, these benefits were associated with good tolerability as adverse events were few with candesartan treatm...revention for migraine sufferers, with an improved tolerability over currently prescribed therapies. These patients could gain a degree of protection from migraine ...Results from open-label Raptiva study suggest continued benefit with long-term treatment
...ticenter trial evaluating the long-term safety and tolerability of continuous Raptiva TM (efalizumab) treatment in patients with moderate-to-severe psoriasis. "The findings from this important open-label study on the long-term safety and efficacy of Raptiva are very encouraging and further support Raptiva'...Phase III study results with Raptiva in the treatment of psoriasis presented at Annual AAD meeting
...-label multicenter trial evaluating the safety and tolerability of Raptiva as a potential continuous treatment in patients with moderate-to-severe psoriasis will be presented by Alice Gottlieb, M.D., director of the Clinical Research Center at the Robert Wood Johnson Medical School at the University of Medicine a...Significant pain reduction for post-shingles patients
...re due to the pungent nature of capsaicin, overall tolerability was good. Dr. Backonja said no safety concerns were identified. A plasma sample analysis of patients confirmed the lack of systemic capsaicin absorption. Postherpetic Neuralgia Every year, nearly 1 million Americans get shingles, a condition caused...Clinical study reports findings of combination therapy with DOXIL
...he Taussig Cancer Center, investigated the safety, tolerability and efficacy of the DVd combination regimen in 33 patients with newly-diagnosed multiple myeloma. In the study, patients received at least six cycles of the DVd regimen. During each cycle, patients were administered intravenous (IV) DOXIL (40 mg/m2...KEPPRA international Phase IV SKATE study results show favourable efficacy
...veral partial seizure types, but also an unmatched tolerability profile. The SKATE study provides data that supports Keppra in the therapeutic armamentarium by identifying this newer antiepileptic as an optimal first choice add-on therapy". He continued, "Given KEPPRA's efficacy in the SKATE study, I am sure tha...Study: Adults maintain significant improvement in ADHD with long-term use of amphetamine
...ment. The studied medication exhibited a positive tolerability profile during the extension trial. The majority of side effects that patients experienced were mild or moderate; those most frequently mentioned included dry mouth, loss of appetite, insomnia, and headache. "There are serious consequences associate...Critical Therapeutics launches Phase I clinical trial of anti-inflammatory compound
...ry aim of the trial is to determine the safety and tolerability of the anti-inflammatory compound over a range of doses in healthy volunteer subjects. The trial will be conducted at the Clinical Pharmacology Research Unit at Parexel, Northwick Park Hospital in the United Kingdom. CTI's Phase I trial marks the f...ENBREL combo therapy inhibits joint damage progression, offers significant RA symptom relief
...me familiar with the benefits and proven long-term tolerability profile of ENBREL. It has been used to treat over 180,000 patients worldwide since becoming commercially available four years ago. ENBREL acts by binding TNF, one of the dominant inflammatory cytokines or regulatory proteins that play an important r...Once weekly ENBREL significantly reduced rheumatoid arthritis pain, inflammation & improved function
...me familiar with the benefits and proven long-term tolerability profile of ENBREL. It has been used to treat over 180,000 patients worldwide across all indications since becoming commercially available four years ago. ENBREL acts by binding TNF, one of the dominant inflammatory cytokines or regulatory proteins t...