Tag: "tolerance" at biology news

Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting

...clude their study suggests that CTLA-4-Ig promotes tolerance in TNBS colitis both via IDO induction as well as through costimulatory blockade, and suggests a potential therapeutic role for CTLA-4-Ig in treating IBD. ...

Hunting illusive signs of natural selection

...opeans have been nearly universally selected for a tolerance for milk, while African and other populations have a high degree of lactose intolerance. The ability to drink large amounts of milk has been strongly selected in Northern Europeans since about 9,000 years ago when dairy-producing animals were domest...

Purdue study finds antioxidant protects metal-eating plants

...mpounds. Understanding the mechanism behind nickel tolerance provides an important tool for researchers like Salt, whose goal is to develop plants that remove toxic metals from the environment in a process known as phytoremediation, or extract useful metals from soil, a process known as phytomining. While pre...

JCI table of contents: 1 September, 2004

...lace of contradiction; on the one hand it has high tolerance for the presence of some foreign tissues as indica...ys a major role in determining the balance between tolerance and immunity. This may have important implications for transplantation studies and for the developme...

Washington University in St. Louis plays key role in sequencing moss genome

.... Studying the genes that control such traits as tolerance to drought stress in the moss might provide keys to how these characteristics could be incorporated into flowering plants. "Once we have the genome of the moss, we will be able to compare the genome of a simple plant to those of complex plants," sa...

JCI table of contents, 16 August, 2004

...rom peptideMHC-I instability and is independent of tolerance AUTHOR CONTACT: Nicholas P. Restifo National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA Phone: (301) 496-4904; Fax: (301) 496-0011; E-mail: Nicholas_Restifo@nih.gov View the PDF of this article at: https://www.the-jci...

A pathway to blocking autoimmunity

...to make dendritic cells that favor recognition and tolerance of self preventing, for example, the destruction of the insulin-producing beta cells of the pancreas that occurs in type 1 diabetes. Once they found that PPAR-gamma was expressed in dendritic cells, the researchers profiled each gene regulate...

Was Atkins right?

...sulin, leptin and triglyceride levels, and glucose tolerance were improved. Calcium balance was not affected by a high intake of milk proteins. Moreover, in contrast to what has generally been admitted, no adverse effects of the high protein diet were reported, particularly regarding kidney and liver health. ...

Protective mechanism exploited by tumors may provide new cancer treatment

...rake and can't move until you take it off. Natural tolerance mechanisms are like a brake that must be removed before the immune system will attack the tumor. "If you take off the brakes (for example with an IDO inhibitor drug), you may make people sick. We need to be very careful that we do not do something th...

Scientists call for better protection for coral reefs

...monstrating how recent research had establishednew tolerance levels for corals. The new findings showed the potentialdevastation this proposed project would have caused. The ISRS seeks to guide organizations such as the World Bank toavoid vague policies that do not clearly articulate the sensitivity ofreefs t...

Mice with hyperactive Wnt10b gene eat all they want, but have half the body fat of normal mice

...ays. "In fact, the insulin sensitivity and glucose tolerance of transgenic mice on a high-fat diet was better than that of normal mice on a low-fat diet. We don't know why, but additional research should provide some answers." Currently, researchers in MacDougald's lab are studying the effect of Wnt proteins o...

Gestational diabetes not found to alter the metabolic processes in obese pregnant women

...body fat less than 25 percent) with normal glucose tolerance (NGT) and gestational diabetes mellitus (GDM) rela...irst-degree relative (n=2), or an impaired glucose tolerance test before conception plus a first-degree relative with type 2 diabetes (n=1). Other than GDM, the ...

Antioxidants during pregnancy may help prevent birth defects tied to alcohol

... by chronic alcoholics, people who have acquired a tolerance for alcohol."Virtually all children born with full-blown fetal alcohol syndrome, with major malformations caused by alcohol, are born to chronic alcoholics," Sulik said. "Chronic alcoholism is a huge problem in our population." Results from...

JCI table of contents, 15 June 2004

... Skin TITLE: Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby AUTHOR CONTACT: Paul J. Fairchild University of Oxford, Oxford, United Kingdom. Phone: +44-1865-275606; Fax: +44-1865-275501; E-mail: Paul.Fairchild@path.ox.ac.uk View the PDF of this article at:...

Conflicting views on embryonic and adult stem cells complicate research in stem cell therapeutics

...and injecting them into the patient creates immune tolerance for other cells types derived from the ESCs, thereby reducing the intensity of rejection by the body. ASCs, on the other hand, are patient derived and do not face the problem of immune rejection. However, for the most part they have not been as versa...

Breast cancer patients failed by treatment with taxol and taxotere respond to abraxane

...l or Taxotere. "The activity of Abraxane and the tolerance of the weekly regimen are impressive in this population of taxane-refractory patients," said Dr. Joanne Blum, Principal Investigator of the study. "Abraxane differentiates itself from other taxanes because it enables us to administer more cancer-fig...

Deciphering the limits to human maximal exercise performance

...logic conditions characterised by reduced exercise tolerance and may guide some new therapeutic approaches....

Drunken worms reveal a genetic basis of alcohol response

... one of the basic risk factors for alcoholism is a tolerance to alcohol, researchers have long sought to understand the genetic differences among people that affect their sensitivity to alcohol. So far, scientists have met with little success. However, by exposing populations of the roundworm C. elegans...

UF researcher: New low-carb potato to debut in January

...rough June. "The variety has high tolerance to environmental stresses like high temperatures or dry weather. In fact, under warm-weather conditions, this variety develops an extremely attractive appearance in terms of brightness of skin and smooth appearance," Northcott said. ...

Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy

... be reversed if the immune system's mechanisms for tolerance -- recognition and acceptance of the body's own ce...olerate, the body's own molecules and cells. "This tolerance is literally what keeps us alive," says Steinman. "Studies in immunology have most often tried to de...

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