JCI table of contents, 1 June 2004
...ce TITLE: CD28 ligation induces transplantation tolerance by IFN-_____dependent depletion of T cells that recognize alloantigens AUTHOR CONTACT: Xue-Zhong Yu Fred Hutchinson Cancer Research Center Seattle, Washington Phone: 206-667-5988 Fax: 206-667-5255 E-mail: xyu@fhcrc.org View the PDF of this article...Maxygen subsidiary Verdia announces discovery and improvement of glyphosate tolerance gene
...ltransferase (GAT) activity that confer glyphosate tolerance to plants. This improvement in enzyme activity ma... Ph.D. "This demonstration of improved glyphosate tolerance should be applicable to many crops. Further, this study validates our ability to create novel comme...Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
...is way, we might be able to induce complete immune tolerance of the liver," she added. According to the researchers, their data are the first to show how TLRs are expressed by liver dendritic cells. "This work has important implications for understanding the liver's inherent tolerogenic potential. But we sti...Study examines future of species extinction, conservation
...matical models looking at changes in a community's tolerance to a particular environmental condition, such as global warming or acid rain. They found that, as individual species start to disappear, two forces begin to act upon a community, making it either more or less tolerant to the environmental condition....UC Riverside researchers improve drought tolerance in plants
...elopment of technology that increases crop drought tolerance by decreasing the amount of an enzyme that is resp...earth's climate is responding. "Increasing drought tolerance in crops is highly valuable to U.S. and world agriculture now and will be even more critical as our ...'Knock out' rose receives Texas superstar and earthkind designation
... and Texas Superstar designations is that a rose's tolerance to pests is so great that you "will almost never have to apply harsh pesticides in the care of these roses," George said. "EarthKind and Texas Superstar plants are the finest, most thoroughly tested and most environmentally responsible plants for use...The APCs of autoimmune disease
...uding T cell deletion in the thymus and peripheral tolerance for T cells that escape thymic deletion. These mechanisms, however, fail in some individuals, resulting in an autoimmune response that can be crippling. Many of the factors, both environmental and genetic, involved in autoimmune disease development r...JCI table of contents, 2 April 2004
...uding T cell deletion in the thymus and peripheral tolerance for T cells that escape thymic deletion. These mec...presenting cells by microbial products breaks self tolerance and induces autoimmune disease AUTHOR CONTACT: Vijay K. Kuchroo Brigham and Women's Hospital and Ha...New insight into how tumors evade the immune system
... novel molecular target for manipulation of T cell tolerance and cell death with profound implications for cancer immunotherapy," explains Dr. Rabinovich. Natalia Rubinstein, Mariano Alvarez, Norberto W. Zwirner, Marta A. Toscano, Juan M. Ilarregui, Alicia Bravo, Jos Mordoh, Leonardo Fainboim, Osvaldo L. Podha......dvantages over those primates, but gained a higher tolerance to meat, slower aging and longer lifespan. Still, if humans developed genes to compensate for a meat-rich diet, why do so many now suffer from high cholesterol and vascular disease? The answer is a lack of exercise and moderation, according to the re...Rimonbant shows promise in addressing multiple risk factors
...ecrease in triglycerides. Improvements in glucose tolerance and insulin levels were also observed. In another important finding, the number of patients diagnosed at baseline with metabolic syndrome, 1 who were treated with rimonabant 20mg, was reduced by half. The drug was also found to be safe and well-to...JCI table of contents, March 1 2004
...it the T cell response in order to generate immune tolerance during transplants and in the treatment of autoimmune diseases such as diabetes. In the March 1 issue of the Journal of Clinical Investigation they report that B7-H1 actually promotes rather than inhibits T cellmediated immune responses, and can dire...Study predicts conditions for sustainable lion trophy hunting
...conservation. Without hunting, there would be less tolerance for lions [by local human residents]. We're trying to defuse some of the disagreement between hunters and conservationists." Other authors of the paper were Anthony Starfield, University of Minnesota professor of ecology, evolution and behavior, and ...Experimental Biology 2004 - Translating the Genome
...or symposia on topics including autoimmunity (when tolerance goes awry) and immunotherapy. Hundreds of presentations focus on topics such as transplantation immunology, protective muscosal immune responses, mechanisms of tumor rejection, genetics of autoimmunity, immunotherapy of cancer, how the immune system...Tips from the Journals of the American Society for Microbiology
...mental sourdough, offering new hope for increasing tolerance levels of wheat flour products. "These results showed that a bread biotechnology that uses selected lactobacilli, nontoxic flours, and a long fermentation time is a novel tool for decreasing the level of gluten intolerance in humans," say the res...Risk and food are on the same plate: World food safety experts offer new methods to assess risk
...isteriosis. (Biggest issue: Can you relax the zero tolerance policy for certain foods, and refocus resources on foods that cause illness?) Leon Gorris of Unilever: Gorris will provide industry perspective on risk assessment, and how it can aid in product development and design. (Biggest issue: What is the co...JCI table of contents, February 2, 2004
...s/19418.pdf Researchers understand what causes tolerance to chronic nitroglycerin therapy for heart disease...enase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance AUTHOR CONTACT: Thomas Mnzel The University Hospital Eppendorf, Hamburg, Germany...Physicists use fractals to help Parkinson's sufferers
...ements. It is also known that the body builds up a tolerance to the drug. Understanding the nature and severity of symptoms for individual patients, which is reflected in their walking pattern, could help doctors improve a patient's quality of life, by guiding their treatment more effectively, and so reduce si...UN report: Accelerate global agreement to oversee exploitation of South Pole 'extremophiles'
...tial applications, including increasing the freeze tolerance of commercial plants, improving farmfish production in cold climates, extending the shelf life of frozen food, improving surgery involving the freezing of tissues, and enhancing the preservation of tissues to be transplanted. A preliminary scan of th...... less tolerant than regular residents, but overall tolerance did not vary greatly between those who suffered lo...g results that payments did not improve individual tolerance towards wolves; further, bear hunters who had received compensation for the loss of a hunting dog we...