New advance to combat antibiotic-resistant pneumonia and malaria
...y examines the mutations responsible for disease's tolerance toward atovaquone (ATV), a drug prescribed since 1995 that inhibits a respiratory enzyme called the cytochrome bc1 complex, that is essential for the pathogen's survival. The lead author, Dr. Jacques Kessl, a research associate in biochemistry at DM...Alcohol exposure in pre- and early post-natal stages may cause insulin resistance
...underwent a frequently sampled intravenous glucose tolerance test (IVGTT). The rats were later killed and incre...first 8 min after the glucose challenge. A glucose tolerance index (KG), representing the net glucose elimination rate in response to both endogenous and exogeno...JCI table of contents, December 15 2003
...loop of glucotoxicity that pushes impaired glucose tolerance into frank type 2 diabetes." TITLE: Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction AUTHOR CONTACT: Bradford B. Lowell Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. Pho...Researchers look to stem cell therapy and bone marrow transplants to find a cure for diabetes
...erglycemic. To gauge whether or not tolerance to islet cell transplantation was achieved, mice t...e marrow transplantation alone, but we did confirm tolerance to islet cell grafts," said Dr. Kang. "Without further manipulation, bone marrow transplantation in...Hope available for patients with anemia and myelodysplastic syndrome
...or 10 mg daily for 21 days every four weeks. Drug tolerance was evaluated at four-week intervals with response assessment according to the International Working Group (IWG) criteria after eight and 16 weeks of treatment. Thirty-six patients could be evaluated for response after completing eight weeks or more...Changing one gene launches new fly species
...erred tropical females. "Developing increased cold tolerance was an important step for flies that migrated out of Africa to Europe and Asia," Wu said. The change in pheromones, which altered patterns of sexual attraction, "was a by-product of adaptation to colder weather." Fruit flies have a migratory histor...A new hope for heavy metal contaminated soils
...d with cadmium and zinc. It exhibits extreme metal tolerance and belongs to a small group of approximately 400 ...hanisms which underlie metal hyperaccumulation and tolerance at the molecular level. For this they exploited the fact that A. halleri is very closely related to ...Three molecular-targeted compounds show promise against cancers
...a variety of tumors. Patient trials evaluated drug tolerance and potential anti-tumor activity against a variety of cancers such as renal cell, colorectal and non-Hodgkin's lymphoma of three compounds. The studies were presented today at the International Conference on Molecular Targets and Cancer Therapeutics...Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
...h show that reduced mismatch-repair proteins cause tolerance or resistance to alkylating agents," Bellacosa explained. "However, it appears that small amounts of DNA damage can be dealt with effectively by reduced levels of these proteins while an effective response to anticancer drugs requires normal amounts...JCI Table of Contents, November 3, 2003
...y formation. The authors found that loss of B cell tolerance can be divided into two distinct components with d...ive T cells enhances the loss of anti-dsDNA B cell tolerance AUTHOR CONTACT : Terri M. Laufer University of Pennsylvania, Philadelphia, Pennsylvania, USA. Phon...New medicines at risk from biodiversity loss
...le suffer from intractable pain and have developed tolerance to opiates, so a potent painkiller like Prialt could represent an enormous therapeutic breakthrough. Just as we are appreciating the remarkable potential of cone snails as a source of new medicines, they are coming under intense pressure in the wild....Hormonal changes in satisfied and dissatisfied shift workers across a shift cycle
...n an attempt to better understand the variation in tolerance of shift work, researchers have focused on the endocrine differences between two types of shift workers, satisfied and dissatisfied. Their results show that the dissatisfied shift workers accumulated problems with sleep and fatigue across a work per...NSF news tips - September 22, 2003
...urn no matches when no match exists, with an error tolerance comparable to that of FBI's fingerprint matching system. Human investigators will still make the final comparisons against the short match list. NSF Media Contact: David Hart, 703-292-7737, dhart@nsf.gov NSF Digitial Government Program: http://ww......******************************** Safely achieving tolerance to stem cell transplantation Dale Greiner and co... GVHD. TITLE: Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning AUTHOR CONTACT: Dale ......iabetes before the development of impaired glucose tolerance Why? Significant differences in glycogen replenish...oking with insulin resistance and impaired glucose tolerance has been established through previous research, the question of whether this smoking affects the fin...JCI Table of Contents, 15 August 2003
...althy, but subsequently developed impaired glucose tolerance progressing to overt diabetes mellitus. The secret...nt of the anti-myelin immune response. The lack of tolerance to MOG may be responsible for the high level of pathogenicity of the anti-MOG immune response as wel...UC Riverside geneticist awarded $2.4 million grant by the National Science Foundation
... crop, with very good genetic diversity related to tolerance of harsh environments. There are extensive collections in Syria, Mexico, the United States and a few other locations. In addition, the barley research community is characterized by tremendous cooperation and sharing in countries all over the globe...On tap: Genomic sequence of an enemy of beer and bread
...s a result, the malting barley industry has a zero tolerance for this fungus. The fungus comes with a steep price tag rendering crops worthless. For example, head blight outbreaks in the 1990s cost U.S. agriculture $3 billion. F. graminearum begins its blighting ways as pinprick-sized pods that spit spores i...Protein holds promise as new diabetes drug target
...lucose levels and improves results of oral glucose tolerance tests in rats and mice with diabetes. Though it will be several more years before clinical trials begin to reveal whether or not drugs based on this compound are effective therapies for diabetes, Magnuson marvels at the progress that's been made sinc......s/17902.pdf Online First articles Increasing tolerance to contact allergens Common contact allergies are... immune response, is required in order to build-up tolerance to such allergens. The authors achieve what is known as low zone tolerance (LZT), in which repeated ...