Belgian researchers explore revolutionary approach to angiogenesis
...s for this anti-tumour adjuvant therapy to be well tolerated are high as ET-1 antagonists would be used acutely to produce an immediate effect on the tumour blood vessels i.e. given at the same time that the chemotherapy or radiotherapy is administered." He said that although the research was in mice and that...Phase II trials of second-generation antisense cancer drug planned following successful early study
...compared to historical controls. The drug was well tolerated by patients. Said Dr. Chi: "We designed the Phase I trial in such a way that we could identify the biologically active dose in the tumour tissue. Being able to identify the active dose in this way gives us confidence that the Phase II dose of the dru...Trial shows which brain cancer patients benefit from temozolomide
...those that were not. Even though the drug was well tolerated it still had inherent toxicity. Patients who were unlikely to respond could be spared side effects and possibly benefit from other treatments that would be more effective for them. Another drug called 06-Benzyl-guanine a substrate for the MGMT enzym...Advances in tumor angiogenesis Dendritic cells co-opted to the dark side
...ion, which in turn may explain why some tumors are tolerated immunologically. "We are the first to show that dendritic cell precursors in tumors build blood vessels," says Coukos. "This has previously been seen in vitro, where others have shown that monocytes or dendritic cells can turn into something that loo...FDA approves VYTORIN, first and only to powerfully reduce LDL cholesterol through dual inhibition
...ents on amiodarone or verapamil. VYTORIN was well tolerated with a low incidence of adverse events VYTORIN ...patients in clinical trials and was generally well tolerated at all doses (10/10 mg, 10/20 mg, 10/40 mg, 10/80 mg). In clinical trials, the most commonly report...Patients' cells from tumors, the immune system merged for customized cancer therapy
...antigens on the tumor cells." The vaccine was well tolerated with only minimal toxicity observed. While a potential concern with vaccine therapy is the induction of an immune response against normal tissues of the body, no evidence of significant autoimmunity was seen. A third of the study participants resp...Acamprosate: potential medication for treating alcoholism
...o the bottle' to feel normal. Acamprosate is well tolerated but needs to be taken a few times per day, unlike ...king and more abstinent days. Although it is well tolerated and does not produce many adverse effects, naltrexone does not work for everyone, leading some scien...Other highlights in the July 7 JNCI
...ir maximum effect at levels lower than the maximum tolerated dose. In a new study, Wendy R. Parulekar, M.D., and Elizabeth A. Eisenhauer, M.D., of Queen's University in Kingston, Ontario, reviewed endpoints used in 60 published phase I studies of targeted, non-cytotoxic anticancer agents. They found that the ...Breast cancer patients failed by treatment with taxol and taxotere respond to abraxane
... without steroid premedication, is active and well tolerated in women with metastatic breast cancer whose disease had progressed while they were treated with paclitaxel (Taxol) and/or docetaxel (Taxotere). Based on analysis to date, results showed a 15 percent (95% CI: 8-22%) overall response rate in 106 patie...APP reports Abraxane(TM) is active in breast cancer patients who failed taxol or taxotere
...y how well this weekly regimen of ABRAXANE TM was tolerated in the breast cancer patients that I treated," sai...tient population. In our study, ABRAXANE was well tolerated with no grade 4 non-hematological toxicities and only a 4% incidence of grade 3 sensory neuropathy. ...Lung cancer patients in Japan, United States react differently to the same chemotherapy regimen
...xel in the U.S. and Japan set these as the maximum tolerated doses for each population. Despite the reduced dose, only one in four of the Japanese patients (24 percent) completed three cycles of the paclitaxel-carboplatin regimen, versus 100 percent of the U.S. patients. And only about one in 10 Japanese pati...Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
...4 patients with advanced solid tumors. The maximum tolerated dose (MTD) of WX-UK1 in combination with capecitabine (Xeloda) will be determined. In addition, pharmacokinetics and pharmacodynamics of the treatment regimen will be investigated....Small trial shows daclizumab add-on therapy improves MS outcome
..." said Dr. Martin. "The combined therapy was well tolerated by all patients, with side effects that were either mild or clearly not caused by daclizumab." He said the therapy limits the activity of T-cells that attack the myelin coating around the nerves, without shutting down the entire immune system. "Whil...Landmark, pivotal Phase IIb/III trial of biotoxin for cancer pain begins
...ularly for four days at the studied doses, is well tolerated and can relieve refractory cancer pain for up to two weeks in some patients. Consistent with the interim analysis, the final results show that almost three-quarters (72%) of cancer pain patients experienced a clinically meaningful analgesic response....Trial found no impact of Malarone(TM) on performance and alertness tasks
...250mg atovaquone + 100 mg proguanil HCl] were well tolerated and had no significant effect on vigilance, alertness, processing complex information, sleepiness and duration or quality of sleep for the volunteers. "Use of medication for aircrew on duty is prohibited by national law and international rules, unl...Combination therapy drives cancer into remission
...e or unacceptably toxic. The mice in the new study tolerated the rapamycin plus doxorubicin combination therapy well, experiencing loss of less than 10% of their body weight. The Importance of "Personalized" Cancer Therapies Based on the Molecular Profiling of Tumors Personalized cancer therapy, still in its...Other highlights of the March 17 issue of JNCI
..., such as letrozole, are more effective and better tolerated than the antiestrogen tamoxifen. To investigate ways to optimize treatment using letrozole and tamoxifen, Brian J. Long and Angela M. Brodie, Ph.D., of the University of Maryland School of Medicine, Baltimore, and colleagues treated a mouse xenograft...Astrazeneca announces EU marketing approval for Faslodex(TM)
...ated with cytotoxic chemotherapy, and to be better tolerated than the aromatase inhibitors and tamoxifen. Commonly reported side effects with 'Faslodex' have included hot flushes, nausea, weakness and headaches. These occurred with similar incidence to anastrozole Unlike many other endocrine therapies, 'Fasl...Tips from the Journals of the American Society for Microbiology
... Sourdough bread containing select bacteria may be tolerated by patients with a rare digestive disease that cau...c flours and started with selected lactobacilli is tolerated in celiac sprue patients. Applied and Environmental Microbiology, 70. 2: 1088-1096.) ...Non-lethal methods can resolve conflicts between bears and humans
...icated dogs on home properties. Some wolves simply tolerated the mild electronic shocks and continued to feed "There is no single solution for every situation but individuals and communities should be given a variety of options so they can tailor their responses to their needs and tolerances," Treves said. "N...