Tag: "trafficking" at biology news

Candidate Regulator Of The Temporal Component Of Neurotransmitter Release Identified

...to share many similarities with general vesicle trafficking events, e.g. protein transport to the cell surface, as employed by cells from yeast to mammals. The major differences are speed - synaptic vesicles can perform secretion within 200 microseconds after arrival of a stimulus - and tight cont...

Jefferson Scientists Find Evidence Of Potentially Infectious HIV In Semen, Despite Inability To Detect Active Virus In Blood

... happen in seminal fluidand could this be from the trafficking of cells from the blood?," he says. Using a powerful molecular technique, polymerase chain reaction, he andhis co-workers found HIV provirus--a precursor form of HIV--in the semen of fourof the seven men. "The question was, is it de...

NIH grantee Günter Blobel wins Nobel Prize for protein signaling discovery

...is work has led to an explosion of knowledgeon the trafficking of proteins in the cell, and even on the way some kinds ofdrugs may be introduced into cells." Dr. Blobel's work has focused on the mechanisms by which proteins are moved, ortranslocated, across cellular membranes. In the early 1970s, he formulated ...

Learning how cell's tiny motor powers its mobility

...University of California,San Francisco. "It's like trafficking goods within a city. These goods include chromosomes during celldivision, and transport of membranes or proteins within cells. "The kinesin motors responsible for this transport are the world's smallest moving machines,even the smallest in the prot...

New link uncovered in nerve cell mechanism thought to power learning and memory

... learn more about the mechanism that mediates this trafficking of AMPA receptors within dendrites." The new study provides these answers. Malinow and his colleagues took advantage of the fact that most of the neurons they study contain AMPA receptors with both "GluR1" and "GluR2" subunits. Receptors with these...

Skin and hair spring from the same stem cells, researchers find

...e division of the stem cells, and then observe the trafficking patterns of the early-offspring TA cells. Results from the study "strongly suggest that the bulge stem cell is bipotent, and that the daughter (TA) cells migrate up to the epidermis and down to the root," Lavker said. Added Sun: "Theres been a t...

Golgi lipids regulate protein trafficking

...of the Golgi apparatus and specifically blocks the trafficking of certain constitutively secreted proteins, while allowing other cargo proteins to be packaged normally into regulated secretory vesicles. The fragmentation of the Golgi apparatus seen in PLA2-overexpressing cells is similar to a change that occurs...

Efficient T-cell trafficking without b7 integrins

...b7 integrins a4b7 and aEb7 have been implicated in trafficking of lymphocytes to the epithelial lining of the int...onsistent with other work showing that that B-cell trafficking to gut-associated lymphoid tissue depends on b7 integrins. In addition, CD8+ T cells from b7-deficie...

The genetics behind miniature plants

...at the copine gene family may function in membrane trafficking and be regulated by the environmental conditions to which they respond....

Defective cell transport suggested in Alzheimer's disease

...re that several of these proteins are involved in trafficking cargo inside nerve cells. In a related report published in the November 8, 2001, issue of the journal Neuron , a team of researchers led by Goldstein showed that disruption of the transport system caused by defects in these proteins can lead to nerv...

UT Southwestern researchers develop new method of delivering vaccines

...des. Small molecules called chemokines attract the trafficking cells and help mediate this process. Lymphatic endothelial cells produce a chemokine known as MIP-3, which binds to a corresponding receptor called CCR7. Langerhans cells utilize CCR7 to migrate from the epidermis to draining lymph nodes, said Takash...

Reserve creates model for science-based indigenous stewardship of land

...ountains. Meanwhile, Colombias civil war and drug trafficking problems are spilling over into Ecuador. Between the colonists, guerillas, warlords, oil companies, loggers and miners, we are sitting on a bomb, Borman explains. Scientific Field Trip Last summer, Dr. Moskovits, other Field Museum, Ecuadorian, and...

A detour for stalled intracellular lipid traffic

...us. Pagano?s group has found that the normal Golgi trafficking of GSLs involves caveolae or some similar speciali...oteins, Rab7 and Rab9, in the clathrin-independent trafficking of GSLs. Overexpression of either protein not only restores their normal patterns of GSL trafficking...

New predictive marker found for prostate and colon cancer

...HIP1 and its relationship to an important cellular trafficking and signaling system called the clathrin-mediated trafficking pathway. Cells use this system to remove old receptors and signaling molecules on cell surfaces and ...

ASPB Annual Meeting, August 3-7, media tip sheet

...fers a developmental perspective on macromolecular trafficking in plants. Alan Schulman, University of Helsinki - addresses dynamic DNA and genome evolution. Kelly Dawe, University of Georgia - speaks on centromeric DNA and chromosome motility. Loren Rieseberg, Indiana University - speaks on the topic of all th...

Study finds link between common neurological disorder and Alzheimer's disease

...comotive. Kinesin-1 is vital for efficient protein trafficking within neurons and other cells, and it's of great interest to us to find it linked to the genes that cause neurofibromatosis." The two genes linked to the disease are among the most commonly mutated genes in the entire human genome. The primary neuro...

Bone marrow cells may contribute to growth of new blood vessels in newborns

..."This study suggests that endothelial cells may be trafficking into those tumors, enabling them to grow. Perhaps by measuring the number of endothelial progenitor cells in the blood we can predict which babies have dangerous tumors and should be treated by drugs and which babies have tumors that will regress ear...

JCI table of contents, March 3, 2003

...t-versus-lymphomaeffects by controlling lymphocyte trafficking with FTY720 CONTACT: Megan Sykes Massachusetts General Hospital Bone Marrow Transplantation Section, Transplantation Biology Research Center MGH East Building 149-5102 13th Street Boston, MA 02129 USA Phone 1: 617-726-4070 Fax 1: 617-724-9892 E-mai...

JCI Table of Contents, April 1, 2003

...o understand the mechanisms ofIgA-secreting B cell trafficking between distant mucosal sites. Havingpreviously identified a chemokine called MEC, which is expressed byepithelial cells in a variety of mucosal tissues, they report now (pages10011010) that the MEC-binding chemokine receptor CCR10 is expressed onIgA...

American Society of Plant Biologists Annual Meeting 2003

...l Lucas: "Plasmodesmata: pathway for intercellular trafficking of macromolecules" Richard Williamson: "Cellulose synthesis" On Saturday, July 26 from 6:00-7:00 p.m. ASPB will recognize Dr. Dennis Gonsalves for his contributions to science and humanity with its 2003 Leadership in Science Public Service Award. D...

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