UT Southwestern biochemist honored with NIH Director's Pioneer Award
...new award. His research involves the regulation of transcription factors, the proteins that switch genes on and off...k in his career was to move from his early work on transcription factors to the study of gene regulation in the brain. One of his current projects has led to the dis...New molecular link key to cellular proteins involved in cancer progression, other diseases
... proteins function in protein complexes to repress transcription of genes that are likely to include key regulators of the cell cycle. The new study demonstrated that a gene normally silenced by the complex becomes switched on in cells when one of the PcG proteins essential for the ubiquitination of H2A has been e...Researchers develop fast track way to discover how cells are regulated
...de regulatory sequences. "Up to now, identifying transcription factor target genes has been a challenge to biolog...y," Mango says. "In addition, we also discovered a transcription factor known as DAF-12 that could bind to the regulatory sequence, and is absolutely necessary for t...Gene expression in liver tumors and patient prognosis
...e, small molecules that inhibit activities of some transcription factors are already available and may provide opportunities to alter the course of HCC progression in both subclass A and B." An accompanying editorial by Joseph Locker, M.D. of Albert Einstein College of Medicine in New York, underscores......sible crosstalk between Rac1 and Paraxis, the only transcription factor known to be essential for somitic MET, they found that Paraxis does indeed require Rac1 in its function as an epithelialization factor, strengthening the argument for its importance in the somitogenic process. The development of a system for i...OutFoxed! New research may redefine late-stage cardiac development
... belongs to a class of DNA binding proteins called transcription factors that turn other genes on and off. Interestingly, Foxp4 is not expressed in heart muscle cells themselves but rather in the primitive gut tube, which will develop into the stomach and intestines. In the early mammalian embryo, the gut tube ...Researchers identify the genome's controlling elements
...e is controlled are gene regulators, also known as transcription factors. These small molecules intermittently land on a region of DNA, close to a particular gene, and then switch that gene on. They can also influence the amount of protein that the gene will produce. Many diseases, such as diabetes and cancer, are...Other highlights in the September 1 JNCI
...ay to measure activation by phosphorylation of the transcription factor STAT1 in response to immunotherapy. The researchers suggest that this new method may be able to help determine the optimal dose of interferon alfa for patients undergoing immunotherapy. Contact: Michelle Gailiun, Ohio State University, 61...Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
...tory neurons. The NPAS1 and NPAS3 proteins are transcription factors that can activate or deactivate other genes. Just which genes they may control is unclear, Dr. McKnight said. Dr. McKnight and his research team are currently investigating what genes and what kind of brain cells the NPAS1 and NPAS3 prot...Integrative biology of exercise APS Intersociety meeting October 6-9, 2004 in Austin
...ivated protein kinase: regulation of metabolic and transcription processes in contracting skeletal muscle. Chair Neil Ruderman. Comparative biomechanics and muscle function in terrestrial vertebrates: in vivo studies. Chair Donald F. Hoyt and James Hicks. In addition to the formal sessions, a large portion of...UCSD biologists develop 'super-endurance' strain of mice
...heavy object, a protein known as hypoxia inducible transcription factor-1, or HIF-1, is activated. This protein enables the muscle to switch to the more energetically explosive, but expensive anaerobic process, which does not use oxygen and generates lactic acid as its byproduct. Two years ago, Johnson and his stu...Engineering endurance: The future of the Olympics?
...oduce ATP. When blood oxygen levels drop, the gene transcription factor hypoxia-inducible factor 1 (HIF-1) triggers the glycolytic pathway. Randy Johnson and colleagues generated mice that couldn't express HIF-1 in skeletal muscle. Normal and mutant mice went through exercise routines that included swimming and ...In gene regulation, small is beautiful
... gene expression. These natural regulators, called transcription factors, prompt particular genes to be active or t.... Creating synthetic versions, known as artificial transcription factors or ATFs, could help scientists probe gene regulation and perhaps lead to new treatment appro...Researchers report new gene test for isolated cleft lip and palate
..., which encodes a gene-activating protein called a transcription factor, plays a role during development in orchestrating the normal formation of the lips, palate, skin, and genitalia. "This study shows that we've reached a point where it's possible to take blood samples from parents, test certain genes, and det...Enzyme activation appears key in helping internal clock tell night from day
...cle consists of an automatically regulated loop of transcription and translation of special clock genes, whose products act as "gears" of the clockwork. Correct cycling is vital to the oscillation of metabolism and behaviors, which happen during sleep and wakefulness. "Without PKG-II, the clock behaves as if lock......t if any of these genes had the ability to control transcription -- that crucial first step in the expression of a ...lick of a Switch Rora is a gene that produces a transcription factor -- a type of regulatory protein that binds to DNA and can turn gene expression on or off like...Retroviral gene therapy? ASLV, HIV, and MLV show distinct target site preferences
...ar a promoter region -- a site that initiates gene transcription -- of a proto-oncogene, a gene that can initiate c...xpressed genes. MLV vectors tend to integrate near transcription initiation sites, confirming the results of a previous study, with a weak bias toward active genes. ...LBP-1a gene mutation linked to disruption of normal fetal development
...ber of a family of proteins called the "grainyhead transcription factors." This is the first gene-based evidence th...ent of blood vessels outside the growing embryo. A transcription factor is a protein that activates a gene and in this way regulates a specific process. The study f...Bad news for pathogenic bacteria: Scientists find protein essential for bacterial survival
...a where many proteins and antibiotics that control transcription may bind to carry out their business." Knowing what roles ppGpp and DksA play in how bacteria respond to stress and other physiological stimuli may help scientists create new antibacterial drugs that target mechanisms specific and unique to harmful......ates monocyte differentiation through the forkhead transcription factor Foxp1 AUTHOR CONTACT: Daniel I. Simon Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA Phone: 617-525-4371; Fax: 617-525-4377; E-mail: dsimon@rics.bwh.harvard.edu View the PDF of this article at: https://www.the-jci.org/...