Gene alteration spurs growth of colon cancer
...have shown that inactivation of the helicase-like transcription factor ( HLTF ) gene contributes to transforming normal colon cells into cancer cells. The gene is a member of a family of genes that removes the proteins that coil around DNA, thus exposing individual genes to the cells gene-expression machinery. H...Researchers will study cell growth, differentiation
...of those interactions, including the regulation of transcription and replication."...Researchers discover mechanism of plant resistance to pathogens
...t activates gene expression through whats known as transcription factors, Sheen says. In particular, these transcription factors may trigger the production of certain plant signals, reminiscent of cytokines in mammals, th...Researchers discover mechanism of plant resistance to pathogens
... activates gene expression through what's known as transcription factors," Sheen says. In particular, these transcription factors may trigger the production of certain plant signals that then turn on more downstream genes ...New light on molecular switch that turns genes off
...etic information, it also impedes access to DNA by transcription factors, proteins that regulate gene expression. Among the biochemical modification mechanisms that can dynamically change chromatin's structure - its loosening or tightening - is histone methylation. This modification mainly occurs on lysine residu...'Wishful thinking' gene regulates neural development
...d that signals sent to the motor neurons activated transcription factors, molecules that switch on genes involved in developing synapses. O'Connor and his colleagues plan to trace how the signal sent from the muscle cell to the motor neuron moves down the axon to the main cell body of the neuron, where it trigger...New mouse model enables studies of heart, brain and spinal cord
... that interact. Other genes do specific things but transcription factors are at the top of the pathway; they control many downstream genes. So one way to try and narrow it down is to make a specific mutation at a specific time in a specific tissue." So the Augusta researchers have developed a mouse with which th...Folding upon binding: unique protein activation mechanism found by scientists at TSRI
...are a nuclear receptor coactivator and the general transcription coactivator called CBP, and their structure is rep...lated, and the body accomplishes this by employing transcription factors. Transcription factors are the proteins that bind to the DNA of the genes and regulate their...Tidying up transcription factors
...ou, Ph.D., propose a reclassification of all known transcription factors - an essential group of over 2000 proteins...heir proposed schema is the first-ever ordering of transcription factors based solely upon the role these molecules play in the cell. "Our aim in this paper is to pr...Stem cells for eggs and sperm also control aging in roundworm
...reproductive system controls lifespan. DAF-16 is a transcription factor a protein that activates genes in response to other signals. The new study shows that DAF-16 is specifically required in the adult worm to allow germline stem cells to modify lifespan. "To my knowledge, this is first gene that has been found ...A genetic basis for behavior in infancy
... report that the -521 T allele reduces the rate of transcription of the DRD4 gene by approximately 40% compared to the -521 C variant, suggesting the functional relevance of this polymorphism for dopaminergic neurotransmission. By genotyping infants for both the length and the regulatory polymorphisms of the DRD4 ...Mice point to genetic basis for obsessive grooming
... genes. Like other Hox genes, Hoxb8 produces a transcription factor, a protein that controls the activity of other genes. Other researchers who had created Hoxb8 -knockout mice had observed abnormalities in the ribs and cranial nerves and noted an impaired reaching reflex in their animals. Those scientists ha...Control of fat cell development demonstrated using Sangamo BioSciences' ZFP technology
...xternal application and validation of Sangamos ZFP transcription factor (ZFP-TF) technology, which enables the spec...FPs) are the dominant class of naturally occurring transcription factors in organisms from yeast to humans. Transcription factors, which are found in the nucleus of...Protein discovery tied to DNA master switch
... information. But it also impedes access to DNA by transcription factors, proteins that regulate gene expression." Zhang and his colleagues believe their discovery to be part of the mechanism that dynamically changes the chromatin structure, its loosening or tightening. They focused their attention on a particula...Required activation 'cascade' identified for p53 tumor-suppressor protein
...form its normal function, which is to initiate the transcription of genes involved in growth control. The findings ...y which many DNA-binding proteins, including other transcription factors like p53, might be regulated. So, in terms of understanding gene control, the implications c...Protein may play role in sex chromosome inactivation
... the work of other researchers who showed that the transcription factor CTCF appeared to be a regulator of imprinted genes that are selectively switched off during development. CTCF sites are known to exist in a number of other genes, in human and mouse genomes, said Lee. And when we simply asked whether the conse...Gene triggers stem cell differentiation in the intestine
...which codes for a gene-activating protein called a transcription factor -- is necessary for the differentiation of three kinds of intestinal cells from stem cells. The team published its findings in the December 7, 2001, issue of the journal Science . Previous work by Zoghbi and her colleagues revealed Math1s r...New clues to how RNA exits the nucleus
...a molecule from the fruit fly, called antennapedia transcription factor. They produced three inhibitory molecules by attaching to the fly peptide short segments of three adapter proteins known to be critical for export. Using these synthetic peptides to selectively block the pathways, the scientists proved that Hu...Post-transcriptional regulation of COX2 in tumor cells
... an increase in mRNA stability, not an increase in transcription rate; on the contrary, the COX2 promoter is far more active in the cells with low steady-state levels of COX-2 mRNA. Dixon et al. attribute the specific stabilization of the message to the expression of the RNA-binding protein HuR, which interacts sp...Protein could help rejuvenate oxygen-starved cardiac tissue, heal wounds
...itself, as HIF-1α is a sub unit of the HIF-1 transcription factor, which regulates the expression of numerous...t cause leakage. Alternatively, he says, the HIF-1 transcription factor may increase expression of an as-yet-unidentified target that modulates vascular permeability...