NIH renews funding for continued Rb2 tumor suppressing gene research at Temple
...f its important roles in cell differentiation, HIV transcription and tumorigenesis. The author of more than 200 published articles, Giordano has done pioneering work in the fields of cell cycle, gene therapy and the genetics of cancer, paving the way to the development of new diagnostic and therapeutic strategies...HIV reveals evolution of a primate defense against intragenomic infiltrators
...th another (uracil) as the virus undergoes reverse transcription in the host cell's cytoplasm. The edited virus fails to replicate. HIV, in turn, generates a protein called Vif that binds to the APOBEC3G enzyme and targets it for degradation, thereby eliminating its antiviral activity. Since the protein-binding re...A pathway to blocking autoimmunity
...ue of the journal Immunity. After finding that a transcription factor called PPAR-gamma is expressed in dendritic cells--the immune system's first responders--Nagy and colleagues used a drug called rosiglitazone to increase PPAR-gamma activity. The additional PPAR-gamma activity prompted immature dendritic cells...Rutgers chemist uses NMR to elucidate protein-DNA interaction
...eraction and offers valuable information about how transcription can be modulated at the gene level." ...XsalF comes to the fore in brain regionalization
...l pattern of its expression showed that it codes a transcription factor related to Spalt and is expressed in the incipient forebrain and midbrain at precisely those developmental stages when brain regions are specified. When members of the Sasai lab overexpressed the gene by injecting its mRNA into early embryos, ...Access to DNA secrets yields better understanding of genes, possible tool for disease diagnosis
... When the DNA relaxes, or expands, proteins called transcription factors gain access to the genetic code to "read" ...like a closed accordion, it's not as accessible to transcription proteins, and cannot make RNA, said Dr. Harold "Skip" Garner, professor of biochemistry and internal...Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
...the structure of those bases and often disrupt the transcription or replication of that DNA. This can retard a cell's growth and lead to its deaththe desirable outcome for cancer cells. The damage these agents cause may not be confined to cancer cells, but the toxicity to the cancer cells is usually greater than ...UCSD team determines cellular stress within body is critical
...h in mice provided the first proof that a specific transcription factor, a gene that acts as an "on-off" switch, is...s NFAT5/TonEBP protein is the only known mammalian transcription factor that is activated by hyperosmotic stress. Steffan N. Ho, M.D., Ph.D., a UCSD assistant profes...Cancer gene MYC emerging as key research target
...s have determined that the MYC protein, known as a transcription factor, binds to about 15 percent of all genes. Sc...of binding without activating may occur with other transcription factors besides MYC. "These kinds of studies and the technology enabling them are so new that many o...Mutant mice lead to memory insights
...scaffold that helps assemble the machinery of gene transcription known to be necessary for formation of long-term memories. And critically, CBP acts as an enzyme that transfers acetyl groups onto the histone proteins that are part of the chromatin enfolding DNA in the chromosomes. Such acetylation is a central pro...Protein believed to control formation of memory identified by Scripps & UCSD scientists
...rk -- the protein CREB. CREB is what is known as a transcription factor, a protein that interacts with the DNA of a...in (CBP). CBP is what is known as a coactivator of transcription -- it works with CREB to control the expression of genes. CBP is sort of like a molecular haberdash...Fat cells could provide the key to a longer life
...he IIS pathway in the fruit fly, dFOXO. Known as a transcription factor, it helps activate and regulate genes. They found that increasing levels of the transcription factor dFOXO in the fat cells of female fruit flies from the onset of adulthood increased lifespan b...From lung to gut the Wnt signaling pathway transforms cell fate
... Okubo. These included the gene encoding the Atoh1 transcription factor, which is normally turned off in lung cells. "In particular there was a very high level of expression of genes characteristic of Paneth cells, which are normally found in the base of crypts in the small intestine," they continue. Signaling dow...Loss of circadian genes results in epilepsy
...on of three circadian genes, encoding the PAR bZip transcription factor protein family, results in accelerated agin...ological functions to the small family of PAR bZip transcription factors," explains Dr. Ueli Schibler, principal investigator of the study and in whose lab the first...UC Riverside researchers discover new way to identify cell growth
...al, Science. The paper, entitled, "TAF1 activates transcription by phosphorylation of serine 33 in histone H2B" is the result of four years of work. Co-authors include researchers from the University of Wisconsin-Madison and Heidelberg University. Medical researchers could use the newly discovered marker as a di...Junk DNA yields new kind of gene
...tural gene from being expressed. "It is the active transcription of another gene that is regulating the process," s...t the new gene, SRG1, works by physically blocking transcription of the adjacent gene, SER3. They found that transcription of SRG1 prevents the binding of a critical...Beware cancer, insomnia and liver disease UH students are taking aim
...ify genes whose activity is regulated by the Prox1 transcription factor that can turn the activity of other genes on or off," Rodriguez said. "The alpha-1 protease inhibitor 5 gene displayed continuous expression, allowing us to propose that it is involved in embryonic liver development. By understanding how Pro...JCI table of contents, 1 June 2004
...al tubular acidosis in mice that lack the forkhead transcription factor Foxi1 AUTHOR CONTACT: Sven Enerback Goteborg University Goteborg, Sweden Phone: 46-31-773-3334; Fax: 46-31-416-108 E-mail: sven.enerback@medgen.gu.se View the PDF of this article at: https://www.the-jci.org/press/20665.pdf ACCOMPANYING CO...Published research contains 'high level of statistical errors'
...authors. The errors seen could have been caused by transcription or typesetting errors, for example if a repeated zero was omitted. Alternatively, researchers may have rounded up figures incorrectly. The researchers showed that some numbers, four and nine, were seen less often than would be expected at the end of...