Molecular mechanisms that trigger flowering in spring
... the day depends both on circadian clock regulated transcription and antagonism between distinct photoreceptors, some of which target the protein for degradation in the morning and others that stabilise it in the evening. The significance of these observations extends beyond Arabidopsis. Recently, Japanese researc...RNA inner workings partly unveiled in Stanford study
...n a cell. But before scientists can understand the transcription process, they must first unveil the inner structur...long with one of the five helper molecules, called transcription factors, in the middle layer. From the structure that could be seen when just a single transcription...Immune system's attack dogs kept on genetic leash
...otein made from the gene already was known to be a transcription factor -- a protein that promotes or suppresses th...of the Foxj1 protein increased activity of another transcription factor, NF-B. "This protein belongs to a family of transcription factors heavily implicated in vari...Gene essential for development of normal brain connections resulting from sensory input discovered
...onse to calcium. "CREST is the first example of a transcription factor-a protein that turns genes on and off-that appears to be specifically required for the development of brain neurons after birth," explains Ghosh, who conducted the study at his former laboratory at Johns Hopkins His new laboratory at UCSD is c...RNA lariat may tie up loose ends to decades-old mystery of retrovirus life cycle
...has remained a mystery since the process ofreverse transcription was first presented almost 35 years ago." The 197...emarkable new insights into the process of reverse transcription of virus-like RNA intoDNA," said Stephen Goff, Higgins Professor of Biochemistryand Molecular Biophy...JCI table of contents, January 2, 2004
...reased nuclear localization of the redox-regulated transcription factor Nrf-2. This, in turn, activated the transcription of genes containing the antioxidant response element (ARE) and a battery of stress response genes. I...Profiling the genes that make stem cells
...ells with existing gene expression data to compare transcription patterns across a wide range of cell types and developmental stages. The expanded mouse transcriptome (record of transcribed genes) included data on unfertilized eggs; "totipotent" fertilized eggs, which have the potential to become any cell; pluripo...A first glance at global genetic networks
... the overall landscape of the expression data. The transcription programs exhibit properties typical of dynamically... a hub. Following these organizational principles, transcription networks would have a relatively small number of highly connected "hub genes"--though a much higher ...Mustard-root map breaks new ground tracking gene expression
...etworks." (Using a gene's DNA as the template, the transcription process creates strands of RNA, molecules that control the building of proteins and serve as catalysts. A network of various biochemical factors, such as signaling hormones, can affect this process.) According to Joanne Tornow, a program director in...Scientists uncover novel role for estrogen in bone marrow
...ed a gene regulator (what scientists refer to as a transcription factor) named p45 NF-E2 as being expressed in mega...ng the formation of blood platelets: The p45 NF-E2 transcription factor turns on 3b-HSD gene expression, leading to the synthesis of estradiol and the subsequent act...Nanotech instruments allow first direct observations of RNA 'proofreading'
...ch will advance our understanding of how errors in transcription underlie disease and will pave the way for better tools to address such problems.'' Other co-authors of the Cell study are Keir C. Neuman, a postdoctoral fellow in Stanford's Department of Biological Sciences; Robert Landick of the University of Wisc...Scientists work to break cellular code
...g this code, she says, is a set of proteins called transcription factors, which bind to specific genes to produce p...urn different results depending on the input data, transcription factors can carry out multiple functions in the cell in response to distinct stimuli. For example, ...JCI Table of Contents, November 3, 2003
... of the Journal of Clinical Investigation. ARNT, a transcription factor of the Per/AHR/ARNT/Sim family, regulates gene expression in response to environmental stimuli such as xenobiotics and hypoxia. To examine its role in the epidermis, Takeda and colleagues disrupted Arnt in keratinocytes. While the architecture...Fruits offer powerful protection from skin cancer
...leus of the cell. This translocation leads to the transcription of Wnt targeted genes, such as c-myc, causing cancer. Skin cancer is the most common cancer, with more than 1.3 million new cases expected in 2003. Additionally, the American Cancer Society estimates that in 2003, there will be 54,200 new cases of m...Cumbre Inc. and collaborator publish on a novel bacterial RNA polymerase inhibitor
...regarding the fundamental processes underlying the transcription elongation cycle."...New class of antibiotics stops pathogens in their genetic tracks
... compounds in order to find one that would inhibit transcription in E. coli. Transcription is the first step of gen...DNA sequence. After finding that CBR703 inhibited transcription in E. coli, the researchers ran the bacteria through a series of tests that allowed them to see wher...Common genetic damages in non-dividing cells lead to the creation of mutant proteins
...es that occur in all non-dividing cells undergoing transcription the everyday activity in which cells produce the ...cells with damaged DNA produce bad messages during transcription that lead to the creation of mutant proteins. During transcription, cells make an RNA copy of the...'Timeless' gene found to play key role as timekeeper in mammals
... It consists of an automatically regulated loop of transcription and translation of gene products important for many diverse physiological functions such as sleep, metabolism and reproduction. The earlier findings had led to the conclusion that timeless was vital only to cellular development in mammals but not to ...JCI table of contents, 15 October, 2003
...ard Medical School, reveals that inhibition of the transcription factor NF-kappaB increases atherosclerosis a chronic inflammatory disease that causes the progressive narrowing and hardening of arteries over time. An initiating event in the development of atherosclerosis is the accumulation within vessels of lipi......s quickly to resistance exercise by regulating the transcription of specific clock genes."...