JCI Table of Contents, September 15, 2003
...gested that 15d-PGJ2 was capable of activating the transcription factor PPAR-gamma. At the time, the finding was of... in renal lesions and end-stage renal failure. The transcription factor AP-1 is composed of Jun and Fos proteins and plays a crucial role in the fine-tuning of cell ...Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation
...f what we know today about the basic principles of transcription and its regulation by proteins in animal cells, Ro...mes' associated helper factors, called the general transcription machinery; and definition of the first of many hundreds of DNA-binding regulatory proteins, cal...Targeting transcription: New insights into turning genes on
...ld and when to stay on the bench, molecules called transcription factors prompt particular genes to be active or st...esearchers have been working to develop artificial transcription factors (ATFs) that can be tailored to regulate particular genes or sets of genes. These molecules c...Similar genetic origins possible for schizophrenia and bipolar disorder
...associated genes were greatly reduced, and several transcription factors known to coordinate myelin gene expression showed corresponding changes," says Yolken. "These results provide strong evidence for oligodendrocyte and myelin dysfunction in patients with schizophrenia and bipolar disorder." Yolken says the re...How tea works against skin cancer
...ers measured activities of the protein kinases and transcription factors in the epidermis, they found that polyphenols inhibited both targets compared to epidermis from mice in the control group. Working with cultured human and mouse epidermal cells, they found a similar pattern. The researchers suggested that po...Battle of the DNA bulge may help thwart cancer
...way monks used to transcribe old scrolls. If a DNA transcription error is made, the body's "spellcheckers" may find...search group are studying a particular type of DNA transcription error called a bulge, as well as the protein "spellcheckers" responsible for finding and repairing b...Schizophrenia and bipolar disorder could have similar genetic causes
...associated genes were greatly reduced, and several transcription factors known to coordinate myelin gene expression showed corresponding alterations. The high degree of correlation between the expression changes in schizophrenia and bipolar disorder provide compelling evidence for common pathophysiological pathway...Study provides new insights into emerging theory of gene regulation
...ning of the DNA coils around the histone to permit transcription of the gene on that length of DNA. "Five to ten years ago, most biologists thought that the proteins that package DNA served only to maintain physical order," Marmorstein notes. "It's becoming clear, however, that these non-DNA elements of chromosoma...Curcumin may be an inexpensive, well-tolerated, and effective therapy for inflammatory bowel disease
...h programmed cell death and activation of NF- B, a transcription factor involved in the production of cytokines and chemokines necessary for inflammation. Regulation of NF- B function has been documented by several agents used in the management of IBD, such as corticosteroids, sulfasalazine, and 5-aminosalicylates...NIEHS study identifies gene for hydrocephalus in mice
...al." "RFX4 belongs to a family of proteins called transcription factors that control expression of other genes," said Perry J. Blackshear, M.D., D.Phil., a co-author of the study. "Identifying exactly which genes are controlled by RFX4 will be an important next step." The NIEHS researchers have already begun to...Protein is shown to aid cell's reading of genetic code
... FACT appearing at the same locations as two other transcription factors on fruit fly ( Drosophila ) chromosomes. To fit into the nucleus of a cell, DNA must be packed into folded structures called nucleosomes that in turn form higher order structures. When the cell needs to manufacture a particular protein, nuc...Splitting hairs: GATA-3 function in hair follicle development
...ncovered an unexpected new role for the well-known transcription factor, GATA-3, in hair follicle development. GATA-3 was previously identified for its role in coaxing hematopoietic stem cells towards a T-cell fate. Now, Dr. Fuchs and colleagues reveal that GATA-3 is also involved in epidermal stem cell specificat...Genes that paint fly derrieres hint at convergence
...The study suggests that the simple modulation of a transcription factor, a protein that can bind to DNA and influen...ic-a-brac2' is selectively influenced - tweaked by transcription factors - to produce a wide range of pattern and color pigmentation on the abdomens of fruit flies a...Findings in frog oocytes may help study of chromosome physiology
...ies of the major components implicated in both RNA transcription and chromatin organization. "When we looked for XC...t this stage condensation is not wanted but active transcription is necessary. This might be one way to prevent condensation. The nucleolus is acting as a trap for ...Development of hair depends on development of the hair channel
...their search to a type of gene or protein called a transcription factor. Transcription factors are like the bosses ...more proteins to the job at hand. Reasoning that a transcription factor heads the job of transforming primitive cells into mature hair channel cells, the researchers...Endostatin promising treatments for AIDS-related cancer
...the cells' nuclei, where it altered the process of transcription a mechanism by which a cell's genetic material reproduces. After nearly two hours, endostatin had cleared out of the cells, supporting the idea that a continuous, controlled-release of endostatin in the tumor area is a viable treatment option, Malle...Study reveals genetic activity of key step in malaria parasite's cycle
...ciparum suggests that a relatively small number of transcription factors could regulate the entire cascade. "If th... the foundation for dissecting the mechanisms the transcription factors -- that control this gene expression program."Plasmodium falciparum infects 200 to 300 milli...Dual discoveries in genetic processing improve accuracy of genome information
...omic DNA in genes shared between species where RNA transcription products are destined to be edited by the enzyme adenosine deaminase. "The signature we found was an unexpectedly high level of DNA sequence identity between species," said Reenan. The signature reliably identifies genes that are recoded during tra...Scientists demonstrate new method for discovering cancer gene function
... C/EBP-beta gene, which makes a protein known as a transcription factor, as a frequent co-conspirator with the genes in the cyclin D1 expression signature. The data strongly suggest, say the scientists, that the C/EBP-beta is involved in regulating genes affected by cyclin D1 overexpression, and is therefore likel...UNC studies identify key genes involved in blood vessel development
...und a possible answer in a single protein, a known transcription factor that has never been characterized functiona...n said. "No other research group hasfound a single transcription factor that by itself is both necessary and sufficient to activate the endothelial cell program."For...