Missing protein is double-edged sword in cancer development
...f a family of proteins called transcription factors. They are critical fo...ntrol, and that extra centrosomes result when this transcription factor is missing. "The consequences are severe for a cel...Baylor researchers show way to diabetes cure with gene therapy
...y, Chan and his colleagues used the NeuroD gene, a transcription factor that induces the liver to produce cells that make insulin and the three hormones associated with the pancreas' endocrine system. The gene was attached to a so-called "gutless" adenovirus from which all toxic genes had been removed. This vira......cientists identified the Arabidopsis CBF family of transcription factors. CBF proteins regulate the expression of c...research by the group revealed that ICE1 is also a transcription factor: During periods of cold stress, ICE1 binds to and turns on the CBF3 gene, which, in turn, ind...Could hibernators hold the key to improving organ preservation?
...tected from cold ischemia/reperfusion injury. A transcription factor, NF-kB, which can initiate pro-inflammatory pathways and has been implicated in liver injury after cold storage/reperfusion, is activated in rat livers. This occurs after 24 hours of cold storage in rat livers, but it is not activated in live...Researchers determine fundamental mechanisms involved in immune response
... to activate Ig differentiation via CSR, a genetic transcription process--during which the DNA is copied to RNA--wa... of DNA is not transcribed. Alt's team showed that transcription leading to the R-loop or other higher order DNA structures containing single-strand regions of DNA i...Arthritis drug suppresses cancer development by stopping action of key protein
...tors have found that celecoxib capsules stop a key transcription factor known as Sp1 from turning on multiple genes...onstrates that cox-2 inhibits VEGF through the Sp1 transcription factor. The researchers used both pancreatic cell cultures and an animal model of the disease to dr...Brain gliomas progress as function of crucial gene is lost
...loss of a crucial tumor suppressor gene, the AP-2( transcription factor, correlates with progression of different h... in breast and prostate cancer as well. The AP-2( transcription factor controls the expression of many genes, including c-Kit, which regulates cellular proliferatio...VEGF gene transfer fails to help peripheral arterial disease patients
...b. U-M teams are now testing techniques involving transcription factor approaches and progenitor cells in both coronary and peripheral artery disease. Many effective drugs and surgical techniques have been developed for blocked heart arteries, but PAD treatments have lagged behind. So, PAD patients may be ideal ...Researchers identify signals that cause hair follicles to sprout
...ancer-binding factor 1" (Lef1), which is part of a transcription complex that controls gene activity. "One of the a...signaling pathway work together by regulating this transcription factor complex. The discovery provides insights into how signals simultaneously operate together to ...Rockefeller scientists identify 'natural' proteins that push stem cells to produce hair, not skin
...so found that beta-catenin works in concert with a transcription factor known as Lef-1 (lymphoid enhancer factor). A transcription factor is a protein that can combine with other proteins (in this case, beta-catenin) so that it can...Common Indian spice pigment can prevent onset of alcoholic liver disease, study finds
...causes of death in this country. Background The transcription factor NF-kB is involved in a number of tissues that are sensitive to alcohol. NF-kB is expressed in fetal and brain cells and is known to be sensitive to oxidative stress that could involve activation of NF-kB in alcohol induced fetal toxicity, brai...Gene that drives cells to commit suicide also plays key role in development of skeletal muscle
...nding on the context in which it works. FKHR is a transcription factor, which regulates the activity of other spec...is, forces us to reassess the impact that a single transcription factor can have on cells, said Gerard C. Grosveld, Ph.D., chairman of the St. Jude Department of Gen...UCSD biologists discover key to blocking inflammation
...activation of a protein known as hypoxia inducible transcription factor-1, or HIF-1, strongly blocked the inflammatory response in mice. Johnson and Cramer were able to show that HIF-1 is essential for metabolism and energy generation of the white blood cells. In mice without a regulatory protein known as the von ...New mouse virus may help scientists better understand cruise ship epidemics
... and Stat1 (for signal transducer and activator of transcription 1). Animals that lack the Rag do not develop T cells, B cells and antibodies. They therefore cannot recognize specific proteins, or antigens, that are found on viruses, bacteria and parasites. That is, the animals lack so-called adaptive immunity, w...A decade later, gene discovered by Temple researchers found to be multi-functional
...ts preferentially by controlling processes such as transcription and the balance between differentiation and apoptosis (programmed cell death), suggesting the important role this kinase can have in controlling or blocking important cellular processes. This is important also from a clinical point of view, conclude...Gene that helps blood vessels form linked to complex birth defect
...ves a group of 24 genes as well, many of which are transcription genes known to control many downstream targets. Although the targets remain largely unknown, it's believed that these 24 genes control hundreds, maybe thousands, of downstream genes, which helps explain the complexity of the syndrome that can result ...... hematopoietic cells, and also fail to express the transcription factor Tal1. To test the effect of Tal1 on hemangioblast development, Dr. Rossant and colleagues reintroduced Tal1 into Flk1-deficient mouse embryos and embryonic stem (ES) cells. These Tal1-expressing, Flk1-deficient mouse embryos still died in ute...Researchers discover that DNA packaging in living cells is dynamic
...s of nuclear organisation and prohibited access to transcription factors. Heterochromatin protein 1 (HP1b) is a key component of condensed DNA, and is strongly implicated in gene silencing. The researchers tagged HP1b with a green fluorescent protein to allow them to follow its movement, and discovered that HP1...Applied Biosystems announces enhancements to Celera Discovery System and new subscription model
...f human gene regulatory regions through mapping of transcription factor binding sites. Panther Universal Protein Library 3.1 protein classifications, which now contain 4,000 additional protein families and 12,000 subfamilies, providing more comprehensive functional predictions. Key literature references perta...UT Southwestern researchers identify gene that could have important role in human wasting disorder
...t the MyoD family of basic helix-loop-helix (bHLH) transcription factors (proteins that act as on/off switches for ... that the MyoR and capsulin genes are related bHLH transcription factors in facial muscles, the researchers showed that specific facial muscles are missing in mice l...