Get your blood moving: Increased blood flow could lead to healthier blood vessels
...move into the cell nuclei where they triggered the transcription of a specially designed reporter gene. In fact, the effect of shear stress alone had the same effect as dexamethasone, a glucocorticoid steroid used to treat inflammation. The researchers helped confirmed these findings in vivo by examining a ...JCI table of contents, January 15 2003
...n that inhibition ofDNA methylation increases IGF2 transcription from one of its promoters,Andrew Hoffman and colleagues sought to methylate this specific promoterregion in the hope of decreasing IGF2 levels and ultimately inhibiting tumorgrowth. As they report (pages 265-273), treatment with a methylatedoligonucl...Knocking the Sox off early mammalian development
... have identified Sox2 as one of the only two known transcription factors (master gene regulators) to be involved in...covery, Sox2 now joins Oct4 as the only identified transcription factors crucial to maintaining embryonic pluripotency. Dr. Lovell-Badge and colleagues show that Sox...'Small RNA' research cited as breakthrough of the year
...ic "orders" from DNA, and through the processes of transcription and translation, help produce the proteins that gi...s." Small-RNAs are now known to be produced by the transcription of tiny genes, in regions of the genome that were previously thought to be vacant or useless DNA. Th...JCI table of contents, December 15, 2002
...s://www.the-jci.org/press/17405.pdf The forkhead transcription factor Foxo1 links insulin signaling to Pdx1regulation of pancreatic beta-cell growth CONTACT: Domenico Accili Columbia University Berrie Research Pavilion 1150 St. Nicholas Av. Room 238A New York, NY 10032 USA Phone: 212-304-5332 Fax: 212-304-7390...Psychiatry receives grant establishing Conte Center to study molecular and cellular mood mechanisms
...tion. He is also investigating the role of CREB, a transcription factor in the brain's nucleus accumbens that is a key control point for mood motivation. Working with Nestler in the Conte Center will be a team of UT Southwestern scientists from psychiatry as well as other departments involved in molecular and cell...UT Southwestern postdoctoral researcher wins international Young Scientist Prize
...neuronal PAS domain protein 2 (NPAS2), a mammalian transcription factor implicated in the regulation of circadian r... UT Southwestern, provides evidence that the NPAS2 transcription factor is directly regulated by carbon monoxide gas. Rutter received his doctorate in cell and molec...Scientists identify 'master' molecule that controls action of many genes
...of DNA into nucleosomes inhibits "unintended" gene transcription by physically limiting the ability of key proteins...leosome structure to allow access to DNA, and gene transcription to begin. A number of these enzymes that are powered by the cell's energy molecule ATP are called "A...Scientists produce the script for life
...e identified how the cell's leading actors (called transcription factors) coordinate the action of all other genes...to changes in environment. Special proteins called transcription factors read a cell's script and perform as lead actors to cue the production of necessary proteins ...Researchers: Protein family key to helping plants adapt
...ene regulation that occurs after the initiation of transcription of the gene and seems to regulate important stress response processes of plants." Transcription is when RNA copies and transfers the gene's instructions to the cell onto a template of DNA. Hasegawa, Bressan and their colleagues have mainly focused o...Shadow proteins in thymus - Clues to how immune system works?
...critical step, the Joslin team discovered that the transcription factor aire plays a critical role in producing the...e possibility is that it works by binding to other transcription factors. "It is going to be interesting to figure out what the mechanism really is," she said. Whil...A red flag for lethal prostate cancer
...control a cell's genetic memory and interfere with transcription the process cells use to transcribe or copy their...t is similar to a gene recently shown to shut down transcription in fruit flies. If additional research and human clinical trials confirm the U-M results, a test fo...UT Southwestern named one of 10 NIH centers for 'Human Proteome Project'
...s to study G protein-coupled receptors (GPCRs) and transcription factors. Studies of these proteins have been limited because GPCRs are difficult to isolate and transcription factors are rare in comparison to other proteins. "For different reasons, those classes of proteins ...Revealed: How a master protein remodels chromosomes to orchestrate gene expression
...igematsu. "We have shown that SATB1 regulates gene transcription by functioning as a 'landing platform' for several chromatin remodeling enzymes, which operate within large but well defined domains." In the 10 October 2002 issue of Nature, the researchers report that, in thymocytes, SATB1 regulates the interleuk...Wrong proteins targeted in battle against cancer?
...ocus more on a specific group of proteins - called transcription factors - known to be overactive in almost all hum...cers. "The facts indicate that a limited number of transcription factors are indeed overactive in many cancers and that these overactive proteins themselves are appr...Advances in 'micro' RNA exploring process of life
...een DNA and a functional cell are the processes of transcription and translation. In transcription, single-stranded...t genes." Micro-RNAs are actually produced by the transcription of tiny genes, in regions of the genome that were previously thought to be vacant or useless DNA. Ho...Researchers identify first genomic blueprint of cancer preventive compound found in broccoli
...ers analyzed the downstream genomic targets of the transcription factor Nrf2 (Nuclear factor E2 p45-related factor ...nse to anticancer agents such as sulforaphane. The transcription factor, Nrf2, in response to cancer preventive agents, turns on genes and pathways inside the cell, ...Laboratory study explains clinical promise of anti-angiogenesis cancer drug
... could only be transcribed, or "read", by the NFkB transcription factor -- along with a snippet of DNA that produce... the interleukin and growth factor molecules whose transcription NFkB usually controls, the levels were lower in the presence of TM too. "It appears that TM exerts ...Research reveals how cells protect against stress
...ment of a cell not only by controlling the initial transcription process but also by controlling the proteins involved in post-transcriptional remodeling of RNA molecules, including RNAs that encode stress-protective proteins," Assmann explains. Another of Assmann's discoveries is that ABA regulates the formatio......ar signal transduction cascade, where it activates transcription of a number of genes, including those that promote cell proliferation. In normal cells, b-catenin is carefully regulated by rapid proteolytic degradation. However, in a variety of tumor types, the b-catenin degradation pathway is disrupted, leading ...