Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...d telomerase activity; both are present inimmortal transformed cells and absent in mortal normal cells. "This suggeststhat hEST2 expression might underlie the activation of telomerase that occursduring cellular immortalization," Dr. Meyerson says. "Blocking hEST2 expressionor activity could halt or slow th...Molecular Piracy Turns Protein Into Traitor
...n host which codes for a chemokine. The virus then transformed it into a potent and broad-spectrum blocker of our chemokine system. Recent research has shown that twoof the chemokine receptors blocked by the new molecule, CCR5 and CXCR4, are co-receptors essential for HIV infection of human cells. This is the f......h, a biomass conversion techniquethat successfully transformed sewage sludge into an asphalt substitute thatcould be used for road paving was developed by the section. Other key projects during this period included: energy efficiency in irrigation alternatives to open field burning energy conversion of food w...Biologist Experiments With His Own Front Yard
...thebehavioral evolution of insects, found that his transformed Tempe, Arizona yard was an ideal homelaboratory where he could conveniently study a wide variety of subjects and conduct experiments morning,noon and in the middle of the night. For lab assistant, he had his wife Sue (who has the patience of a saint)...Jefferson Researchers First To Create Genetically Engineered Mouse To Study Photoaging
...arrangement of normal elastin fibers is alteredand transformed into large haphazard clumps, causing the skin's exterior tobecome leathery and wrinkled. Dr. Uitto developed and bred the transgenic mice. They microinjected fertilized mouse eggs with human elastin promoter linked toa chloramphenicol acetyltransfer...UPMC Researchers Report On Gene Therapy Advances
...TSBURGH, March 16 -- The field of gene therapy has transformed dramatically,moving from its anticipated primary a...at blocks thebinding of IL-1 to its receptor. The transformed cells are injected into thejoints one week prior to the patient undergoing previously scheduled join...Biotech Firms Develop Where Star Scientists Worked, Study Shows
... Economic Review . Advances in biotechnology have transformed the pharmaceutical industryby allowing creation of novel drugs and treatments. Biotechnology has alsobeen used extensively in the food processing and agriculture industries,among others. For this study, the researchers identified 327 “star”...Perkin-Elmer, Dr. J. Craig Venter, And TIGR Announce Formation Of New Genomics Company
...of healthcare delivery and medical practice willbe transformed by molecular medicine. We believe that the information developedby this new company will become the cornerstone of this new paradigm andaccelerate development of new therapies, targeted diagnostics, and individualizedmedicine - providing therapies ta...Molecular Circuit Breaker Can Prevent Runaway Cell Growth
...mal cells resistcertain oncogenes and refuse to be transformed into cancer cells. "Wehave known for 15 years that genes like Myc and E1A help toovercome this resistance. Myc and E1A kill normal cells by activating theARF-p53 checkpoint," says Sherr, "but they also select for the emergence of raretumor cell...New Rehabilitative Device Combines Form And Function For Children With Mobility Impairments
...ing interchangeable parts,the prone stander can be transformed into an alternative walker or agait trainer (for children who have advanced beyond the prone stander). For the past six months, The Buddy System has been "road-tested" at theElaine Clark Center, an early intervention program in Atlanta. "Thereaction ...Did You Know? The Truth About The Poinsettia
...the United States in 1825. How was a tropical tree transformed into the beautiful, branched plants we findin today's florist shops and stores? "Special seedling cultivars were firstintroduced in 1923," says Ing Ming Lee, USDA plant pathologist and member of theAmerican Phytopathological Society. "Until recently ...Immortalizing Enzyme Does Not Make Human Cells Cancerous
...ythe introduction of the enzyme telomerase are not transformed into cancer cells,perhaps clearing the way for saf...man cells # instead of theanimal cells or abnormal transformed human cells now available # may help indrug development, screening and testing. Genetic engineering ...Engineered Corn Can Kill Monarch Butterflies
... corn pollen survived the study. The toxin in the transformed pollen, the researchers say, goes into the gut oft...eld testing in the United States. As of last year, transformed corn, potatoes and cotton had been approved by theU.S. Department of Agriculture for commercial use....New components of machinery that carries genetic information from nucleus
...es coded forkinases, or at least their regulators, transformed IP3 to IP4, and IP5 to IP6. According to York, still to be determined is whether IP6 directly orindirectly affects the transport of mRNA from the nucleus. IP6 may merelyregulate the "gatekeeper" -- called the Nuclear Pore Complex -- a huge p...New UNC-CH study explains variations in onset of ice ages
...antbecause finding out how Earth's environment has transformed heat from the suninto climate variations can help predict future global climate change," Rialsays. "Eventually this kind of work will teach us how the whole climate systemworks not only over very long time scales, but also perhaps over very shortspan...Enzyme-based method to isolate stem cells from umbilical cord blood shows promise
...zyme, they quicklyexpelled BAAA before it could be transformed to BAA -- in the same way thatmultidrug resistant cancer cells quickly pump out chemotherapy drugs. But the researchers had a solution. They knew that a drug called Averapamil canstop cancer cells from pumping out chemotherapy drugs. So, the study's...Social behavior transformed with one new gene
For the first time, researchers have transformed an antisocial mouseinto a more social animal by genetically manipulating the distribution of aspecific receptor in the brain. Neuroscientists at Emory University created a transgenic mouse by insertinga gene from a prairie vole, a rodent speci...Common parasite overturns traditional beliefs about the evolution and role of hemoglobin
...gen. The primordial function ofdetoxification has transformed into a respiratory function in man." While it appears that Ascaris hemoglobin is primarily involved in thecanceling out of oxygen, the Duke and Washington University research also pointsto another function -- protecting the worm from NO that ...Researchers say hormones are key to evolution of insect metamorphosis
...they lacked genitalia and bore wing buds that only transformed intofunctional wings during the molt to the adult stage. In both cases, the insectsmolt, or shed their external skeletons, several times as they grow to adults. The higher insects, species with complete metamorphosis, spend their juvenilelife as larv...The future of planet earth: scientific challenges in the coming century
...s actually move downstream and how much is lost or transformed to harmless forms. More information on the nutrients is available in the report, "The Quality of Our Nation's Waters -- Nutrients and Pesticides," at water.usgs.gov/pubs/circ/circ1225/ or contact USGS scientist Pixie Hamilton at 804-261-2602. More...