A new way to engineer cells: The Staudinger ligation
...we could create a different kind of aza-ylide that transformed into a stable adduct. Staudinger would have loved the challenge!" Bertozzi and Saxon added an electron-hungry carbohydrate trap to the phosphine, which attaches to the electron-rich aza-ylide and prevents it from falling apart in water, subsequently ...UCSD study of uncoordinated fruit flies provides molecular clues to hearing problems in humans
...nical energy in the form of sound and touch can be transformed by tiny mechanoreceptor cells into chemical and electrical signals that are processed by the brain to hear, sense touch, maintain balance and determine the position of one's limbs in space. Many of these cells, which are found in vertebrate and inver...Adult stem cells can produce a wealth of cell types, Science authors report
...so planning future experiments to see how long the transformed stem cells survive within these tissues, and whether they retain their new commitments indefinitely....Bt corn variety found to be safe to Illinois butterfly
...ollen from non-modified corn. Pollen from another transformed variety, Novartis Max 454, however, did cause mortality in the laboratory. Antibody assays of the Novartis event showed that it contained 40 times as much endotoxin on average than did the 810 variety. "This is not the green light for all forms of ...Scientists issue telomerase caution
...lthough the immortalized HMEC cells were not fully transformed into a cancerous state, elevated c-myc expression is a major step in the multistep process leading to the malignant transformation of cells. Altered expression of the c-myc oncogene is observed in approximately 70,000 fatal cancers per year in the ...Do fish farms really add to the world's supply of fish?
...sts and coastal wetlands throughout Asia have been transformed into milkfish and shrimp ponds. The consequence has been a devastating loss of nursery habitat for indigenous species of finfish and shellfish that people have long depended on in countries such as Indonesia and the Philippines. Another problem, say...Experiments point to new theory of skeletal development
... digit it was supposed to form, but the other half transformed to the identity of the neighboring digit. Transla...interdigital BMP levels, the Wisconsin researchers transformed the identities of the neighboring digits. Taken together with reports from other scientists, this ob...October Geology and GSA Today highlights
...st abrupt climatic events in the geological record transformed Earth. A brief but intense interval of global warming heated up the oceans and atmosphere. The magnitude and abruptness of the event can be explained by a series of catastrophic releases of the greenhouse gas methane from the seabed, which perturbed ...Gene found to contribute to deadly form of breast cancer
...e activities is a hallmark of cells that have been transformed into cancer cells - they tend to reproduce without brakes and form colonies, move around the body, cling to each other and to anchor locations, and form blood vessels to feed themselves. Armed with that knowledge, the U-M team set out to study the ...Adult stem cell therapy for heart failure proves promising
...scle side by side with the injected cells that had transformed into heart muscle. "If the two were not connected, this protein would not develop and such connections are important for them to beat together," he notes. He and his colleagues made another intriguing finding. Two groups of cells were produced fro...Clinton names a diverse group of researchers to receive the 2000 National Medals Of Science
... "These exceptional scientists and engineers have transformed our world and enhanced our daily lives," Clinton said. "Their imagination and ingenuity will continue to inspire future generations of American scientists to remain at the cutting edge of scientific discovery and technological innovation." Te...Raven one of 12 to receive National Medal of Science
...s."These exceptional scientists and engineers have transformed our world and enhanced our daily lives," President Clinton said. "Their imagination and ingenuity wlll continue to inspire future generations of American scientists to remain at the cutting edge of scientific discovery and technological innovation."...Global warming: lessons taught by snails and crabs
...sturbing signs that higher ocean temperatures have transformed wildlife populations in the Pacific. ``The effects of global warming already seem evident,`` says Somero, the David and Lucile Packard Professor in Marine Science at Stanford. ``The vast majority of scientists regard continued warming of the Earth a...Discovery may jump-start mine remediation efforts
...es are exposed to air and water and the sulfide is transformed to sulfuric acid. Moreover, metals such as zinc are toxic and can leach into ground water and contaminate wells and other drinking water supplies. Working with Ken Kemner and colleagues at the Advanced Photon Source at Argonne National Laboratory, th......refractory low grade, follicular, or CD20-positive transformed B-cell Non-Hodgkins Lymphoma (NHL). He noted that ...g relapsed or refractory, low grade, follicular or transformed NHL patients with mild thrombocytopenia (platelet count between 100,000 and 149,000/mm3) with ZEVALI...Three genetic steps convert normal mammary cells into breast cancer cells
...tion, the researchers detected in the artificially transformed cells amplifications of the c-myc oncogene, anothe...t only the autonomous and uncontrolled growth of a transformed cell, but that it also relies on a specific cross-talk between the tumor and its microenvironment. ...Pauling Centenary to recognize scientist, humanitarian
...r level," Lawson said. "His textbooks in this area transformed the teaching of chemistry and have been used by generations of students. Paulings application of development of X-ray and electron diffraction opened the exploration of many inorganic compounds, resulting in publication of the structures of hundreds ...Language can fuel, or abate, public fears about bioengineered foods
...derstanding of their audience, "the information is transformed in that it becomes a different message, one adapted to the specific needs of the audience," he said. Certain communication models, such as the practice Katz calls "one-way communication" in which the educator or expert does all the talking and th...Calcium signals found to guide nerve cell development
...In the mature nervous system, the growth cones are transformed into synapses, the communication connections between the nerve cells. "The movement, the steering, the guiding in the growing nerve cell is all done by the growth cones," says Spitzer. "The growth cones are the pioneers, leading the way for the grow...UCLA/Pitt researchers transform human fat into bone, muscle, cartilage
...we once thought. Just as the Industrial Revolution transformed oil from trash to treasure, our research shows that unwanted human fat actually is a vigorous tissue with a tremendous amount of potential for good." The researchers said the discovery could render the controversial use of fetal tissue obsolete. ...