Tag: "translocation" at biology news
DNA Enzyme Works In Crystal Form; Yields New Insights Into Gene Copying
... process proceeds are unclear," she said. "We know translocation
must occur,but whether it happens before or after the nucleotide is bound, nobody has evertracked." To reveal the detailed process, the scientists plan to produce movies bytaking series of high-speed X-ray snapshots of the enzyme in action. ...
Hormone Control Of Rare Leukemia Sheds Light On Molecular Basis Of Cancer
... The genetic mistake that makes APL so deadly is a translocation
betweentwo chromosomes. These chromosomes break and fuse together again during cellulardivision, resulting in a new gene with material from each. The protein encodedby the new gene is called a fusion protein. Chromosomal translocations figure inmany ...
Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation
...iquitylated substrate protein and ends with its translocation
into the 20S proteolytic core....
Structure Of The Plasma Membrane Proton Pump Offers A First Glimpse Of The Mechanism Of Ion Pumping Across Membranes
... the ion occlusion and molecular mechanisms of ion translocation
catalyzed by this important family of ion pumps....
The Touch Of Phytophthora
...self this local mechanical stimulus induced the translocation
of cytoplasm and nucleus to the site of stimulation. Interestingly, some of the biochemical defense responses were also observed. Only a few minutes of local mechanical stimulation were required to induce the intracellular generation of R...
Researchers Probe New Depths In Plant Communications
...e plasmodesmal tunnel to the subway line, orphloem translocation
stream. Once in the subway line, thecomplex of movement protein and mRNA travels very rapidly todistant stations located in roots and flowers. At its destination, the report suggests, the messenger RNAprobably influences the level of some other prote...
NIH grantee Günter Blobel wins Nobel Prize for protein signaling discovery
...in1975 of a test-tube system that mimicked protein translocation
in the cell. This allowed the biochemical dissection of the process, leading to a series ofkey discoveries in his laboratory. More recently, Dr. Blobel has studied the mechanisms governing the bidirectionaltraffic of proteins into and out of another ...
Emerging infectious diseases of wild animals are a threat to biodiversity and human health, according to new report
...domestic animals to wildlife populations; with the translocation
of host or parasites by human intervention; and wi...attle becoming infected, according to Daszak. The translocation
of wildlife species - the second method of spreading emerging infectious diseases - occurs o...
DNA details suggest how human chromosomes break, rearrange and cause a genetic disease
...able, and allow us to propose a model for how this translocation
occurs," said Beverly S. Emanuel, Ph.D., chief of ...tive diagnostic test to help parents who carry the translocation
ensure that their future children do not have the syndrome. Unlike more random chromosome transl...
Screening embryos for 'problem' chromosomes
...lthy embryos are transferred to the uterus. "Of 65 translocation
diagnoses we have carried out, the spontaneous abortion rate was only 15%, compared with 95% of the pregnancies conceived without screening," Dr Munn said. "One in a hundred women over 35 may have aneuploidy and this rises to four in a hundred for wo...
'Gatekeeper' protein is key to cellular life; links bacteria, chloroplasts and mitochondria
...ture, may suggest a completely new pathway for the translocation
of proteins within basic biological units. Even more startling was the discovery that several other proteins that are remarkably similar to YidC may play similar roles inside mitochondria and in chloroplasts as well. The discovery suggests that bac...
'Translocation' surgery yields unprecedented results
...e importance of early management of AMD: "Macular translocation
is effective only for people just diagnosed. Once they've had the disease for a few months, it may be too late." To date, he has performed close to 400 of the operations....
Common genetic differences affect vulnerability to childhood leukemia, new study shows
...as other chromosomes. Two other forms are known as translocation
subtypes, characterized by abnormal chromosomes formed during development of the blood cells before the child is born. In the new study, the scientists used molecular probes to classify 253 British childhood leukemia patients into one of three leukem...
Researchers identify gene for rare form of leukemia that strikes infants
...rs found two novel genes involved in a chromosomal translocation
(the exchange of genetic material between non-homologous chromosomes) that is highly specific for this type of infant leukemia. One gene on chromosome 1 and one gene on chromosome 22 are fused together creating an abnormal fusion gene. "The most im...
Highly specific biological agents attack mechanisms of treatment resistance
... In its initial stage, it has only one mutation a translocation
between chromosomes 9 and 22 that results in a Bcr-encoded sequence fused to a truncated c-Abl gene. The resulting Bcr-Abl protein greatly increases c-Abls tyrosine kinase activity and is directly responsible for all the clinical manifestations of CM...
Researchers distinguish new type of leukemia
... chemotherapy. Researchers had discovered that the translocation
involved a gene that they called the mixed lineage... Golub and their colleagues theorized that the MLL translocation
might cause aberrations in metabolic pathways that would indicate that the drug-resistant form of le...
U. of Colorado researchers identify switch that controls aging in worms
...p a pharmaceutical intervention that would trigger translocation
of DAF-16 into the cell nucleus of a variety of animals, including humans, said Henderson. This would cause organisms to lower their reproduction level and fight off the negative impacts of free radicals....
CNS cell death in bacterial meningitis
...luding chromosomal condensation, DNA cleavage, and translocation
of phosphatidylserine to the cell surface. Here, Braun et al. show that AIF activation and cell death can be induced by either of two secreted bacterial factors: hydrogen peroxide and the toxic protein pneumolysin, which forms pores in animal cell me...
Complex gene-swapping spawns a form of lymphoma
...yses revealed that all the tumors showed a complex translocation
-- a complicon -- that involved specific regions o...rprise, because when we originally detected such a translocation
between the two chromosomes, it resembled those of Burkitt's lymphoma which just involve human equiv...
Possible gene for form of mental retardation, brain development identified
...esearchers knew that this patient had a chromosome translocation
between one of the X chromosomes and one of the nu...and then switched pieces. They suspected that this translocation
resulted in a mutation in one of the genes on the broken X chromosome and that the mutation could ha...