Tag: "transplant" at biology news
Pacific Northwest team unveils largest virus proteome to date
... cause of birth defects and is a serious threat to transplant
and AIDS patients and others with a compromised immune system. "Our labs identified the viral and host proteins that compose the HCMV virion," said Jay Nelson, Ph.D., director of the OHSU Vaccine and Gene Therapy Institute (VGTI) and a study co-au...
Experimental drug shown to block mutant protein causing blood disease
...sease wasn't cured and she underwent a bone-marrow transplant
to treat the acute leukemia caused by her MPD. PKC412 acts similarly to the pioneering drug Gleevec, one of the first drugs to treat cancers by shutting down abnormal kinase signal switches. Gleevec blocks uncontrolled growth signals in Chronic Myelo...
Bone marrow cells routinely help with wound healing
...arrow from the mice and then performed a stem cell transplant
into a genetically identical strain of normal mice, whose cells do not glow green. Afterward, only the bone marrow of the transplanted mice glowed green inside the bodies of the mice, allowing researchers to track the bone marrow cells throughout the...
Skin stem cells give hairless mice hair
... Fuchs. "Previously, researchers have done similar transplant
experiments with dissected parts of the hair follicle. And, while they've had evidence that hair follicle structures were forming, they didn't see generation of hair. "In contrast, in our experiments, we saw quite a density of hairs, in some cases a...
Patented process preserves transplant tissues/organs
...rtificial), has been the problem of preserving the transplant
tissue. Better preservation techniques would allow transplant
materials to be shipped anywhere in the world or, better yet, collected and stored in something akin...
Probing the surface of white blood cells to enhance immune system medicine
...ead to a less toxic form of immune suppression for transplant
recipients. Since many cancer cells share the same mechanism of extravasation as lymphocytes, ablating microvilli could also prevent metastasis of cancer cells to distant parts of the body. Similarly, by thwarting lymphocyte migration to deposits of ...
U of T study identifies possible stem cells in pancreas
...could provide a plentiful supply of beta cells for transplant
treatments. A finding Smukler considers equally exciting is their discovery that these pancreatic cells generated both beta cells and neurons, cells associated with the workings of the brain and the nervous system. "The existing dogma regarding how d...
New model can aid in understanding immune system diseases
...cing treatments for patients with AIDS or an organ transplant
who get a certain type of cancer, and for people with immune system diseases such as lupus, arthritis and multiple sclerosis. The study results appear in the August issue of the journal Immunity. The advance builds on previous UI studies done in cell...
Stem cell research targets cerebral palsy
...rebral palsy to identify the most effective way to transplant
stem cells and possibly answer that question. With this latest grant, Dr. Carroll, who also treats patients with cerebral palsy, wants to determine whether transplanted stem cells work best when the cells are injected directly into the brain along wi...
Joslin Diabetes Center launches research section on developmental and stem cell biology
...viding a vast supply of insulin-producing cells to transplant
into individuals with diabetes, and for preventing diabetic complications. We're also keenly interested in exploring the effects of a mother's diabetes on the developing embryo so that we can minimize birth defects," says George L. King, M.D., Josli...
U-M scientists find common virus in human prostate tissue
... especially those who have just received a kidney transplant
the virus can cause serious kidney and bladder di...omavirus family. It was first discovered in kidney transplant
patients who take immunosuppressive drugs to prevent their body from rejecting a new kidney. Scienti...
New discovery may help transplants survive
...ant promise not only for new treatments to prevent transplant
rejection but also for diseases such as cancer tha...the "unwanted" immune response that causes corneal transplant
rejection. VEGFR-3's role in activating the immune response in the cornea is the most recent in a se...
Babies with DiGeorge syndrome saved by immune supression, thymus transplant
... with complete DiGeorge could not receive a thymus transplant
because some of their bone marrow cells had sponta...ssant drug given for three days immediately before transplant
surgery resulted in successful thymus transplants. Five of six infants who underwent the new procedu...
JCI table of contents, 2 August, 2004
...rom p27kip1 defective mice into normal mice, these transplant
mice had higher a higher prevalence of arterial bl... cause of chronic liver disease in children. Liver transplant
is ultimately the only treatment, as little is known about the underlying pathogenic mechanisms. Ind...
Genetic discovery could dramatically reduce need for liver transplants in children
...our children who have biliary atresia need a liver transplant
before the age of 20. The total annual cost, including transplant
care, of treating all infants with biliary atresia is estimated to be $65 million. In a previous stu...
UCSD team determines cellular stress within body is critical
...gs may have implications for autoimmune disorders, transplant
rejections, and potential cancer therapies. Publis...development of drugs to treat autoimmune diseases, transplant
rejection and cancer. "We are particularly excited about the implications of our findings to cancer...
Macrophages, not stem cells, correct liver disease by fusion
..."The most important discovery is you don't need to transplant
stem cells at all," said study co-author Markus Gr...d director of the Oregon Stem Cell Center. "If you transplant
only macrophages, you'll get liver cells that correct liver disease in mice." Holger Willenbring, M....
Newly grown kidneys can sustain life in rats
...ld rats. Prior to insertion, scientists soaked the transplant
tissue in a solution that included several human g... approximately 10,000 kidneys become available for transplant
into patients with end-stage kidney disease," Hammerman says. "But the waiting lists for kidney tran...
A protein's role in progressive renal disease
... made a brief media splash last year when a kidney transplant
forced NBA superstar Alonso Mourning into early retirement. Mourning's condition elicited a flood of calls from fans offering their kidneys, but most people with kidney disease are not so lucky. Some 56,000 patients await transplants; many have wait...
Umbilical cord blood transplants, bone marrow transplants save lives
...treatments have produced no results, a bone marrow transplant
may save the patient's life," said Dr. Patrick J. ...a University Chicago Stritch School of Medicine. A transplant
provides the patient with healthy, new stem cells to develop a new immune system. And it's working....
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