Cancer Test May Offer High-Risk Groups Quick, Affordable Screening For Tumors
...neallopurinol pill. This drug, ordinarily used to treat gout, also temporarilyinterferes with the production of elements of DNA called pyrimidines. Patients'urine was then collected in four periods over the next 24 hours and tested forincreased levels of orotidine and orotate, two compounds used to build...Scientists Say Latently Infected Cells May Stoke the Fire of HIV Replication
...s research to prevent, diagnose and treat illnesses such as HIV disease and other sexually transmitted diseases, tuberculosis, malaria, asthma and allergies. NIH is an agency of the U.S. Department of Health and Human Services.......iciency in the blood clotting protein factorIX. To treat or prevent serious bleeding episodes, patients currently receiveintermittent or regularly scheduled infusions of factor IX obtained from pooledhuman plasma or produced by recombinant DNA technology. Such treatments cancost up to $100,000 per year, a...Gene May Hold Key To Treating Life-Threatening Cholesterol
... suggests that we can develop an excellent drug to treat high levels of dietary cholesterol by altering the molecules that bind with LXR-alpha. Now we will use different levels of dietary cholesterol in longer-term studies to see if it causes atherogenesis in these genetically engineered mice," he said. "A...Gene Therapy May Suppress Uterine Fibroids
... them, suggesting it may ultimately be feasible to treat uterine leiomyomas with gene therapy." The method of gene therapy Christman uses has been shown to inhibit the spread of malignant cancer cells, but malignancies grow too fast and DNA delivery systems currently are too imperfect to make gene therapy ...University Of Pittsburgh Scientist Discovers How A Novel Vitamin K Stops Cancer Cell Growth
...ental work usingvitamins A, D and K to prevent and treat various forms of cancer in laboratoryanimals and in clinical trials with patients. As one of 31 National CancerInstitute-designated comprehensive cancer centers, UPCI is recognized for itsinterdisciplinary approach to cancer prevention, detection, d...New Model Makes It Possible To Predict Emergence Of Antiviral Drug Resistance
...esistanceoccurring with increased use of a drug to treat genital herpes. The findingspredicted that while ...lopment, which markets the drug acyclovir, used to treat genital herpes....Interleukin-12 Helps Control Mycobacterium Avium Infection
..., M.D., director of NIAID. "It's very difficult to treat this infection in AIDS patients," comments Dr.Sher...enceof T cells, a potential advantage when used to treat immunocompromised patients. Through a series of experiments conducted in immunodeficient mice, Drs. ...Mouse Model Of Down Syndrome Offers Glimpse Into Role Of Specific Genes In TheDisorder
... research would lead to thedevelopment of drugs to treat humans with Down syndrome, which causes mentalretardation, major and minor physical abnormalities, often including heartdisorders, and, in later life, Alzheimer's disease. The new mouse model, called Ts1Cje, includes a partial third segment of mousec......fficient understanding," said Leiden, "we can only treat the symptoms, not the underlying disorder." Even the value of diet and exercise as therapy for heart failure remain unsettled. By altering one mouse gene, however, the research team has created a very accurate animal model of the disease. They in...New Medication Means New Choices For Families Dealing With Alzheimers Disease
...ared for at home, families overwhelmingly chose to treat thepatient. For those patients who lived in a nursing home and the disease wasfairly advanced, families chose to withhold the treatment." Kettl says these kinds of difficult ethical questions will have to befaced by more and more families as ...Scientists Identify Molecular Target For Tuberculosis Drug Treatment
...cience. Although isoniazid has been widely used to treat people with tuberculosis, untilnow no one knew exa...ports biomedical research to prevent, diagnose and treat illnesses suchas AIDS, tuberculosis, malaria, asthma and allergies. NIH is an agency of theU.S. Dep...Rockefeller University Researchers Continue Search For Genetic Ties To Hearing Loss
...d in the development of intervention strategies to treat and prevent hearingloss," says Suzanne Leal, Ph.D., principal investigator of the study andassistant professor in the Laboratory of Statistical Genetics at Rockefeller. Hearing impairment, which ranges in severity from modest difficulty with speechco...Molecular Key To Heart Failure Development
...ymay point the way toward new drugs to prevent and treat heart failure in people. "Our goal is to understand the molecular mechanisms of heart failure--tounderstand what molecules or pathways are involved in the formation of heartfailure and why the heart progressively fails until it can no longer function...Naked DNA Rejuvenates Rheumatoid Rodents
...e unveiled a stripped-down form of gene therapy to treat arthritisin an experimental animal model. Naked D...onths after treatment. The use of TGF- plasmids to treat arthritis evolved from previous work by Dr.Wahl, director of NIDR's Oral Infection and Immunity Bran...Crystal Structure Of Key HIV Protein Reveals New Treatment Targets
...ports biomedical research to prevent, diagnose and treat illnesses suchas AIDS, tuberculosis, malaria, asthma and allergies. NIH is an agency of theU.S. Department of Health and Human Services....Relapsing Fever Spirochete Switches Surface Proteins When It Changes Hosts
...ports biomedical research to prevent, diagnose and treat illnesses suchas AIDS and other infectious diseases, asthma and allergies. NIH is an agencyof the U.S. Department of Health and Human Services....Brain Antibodies Provide New Clues To Origins Of Tourette's
...ind theinfectious trigger, and develop new ways to treat or prevent Tourette's in asmall number of affected children, according to Singer. With funding from the National Institutes of Health and the Tourette'sSyndrome Association, Singer's group took blood samples from 41 Tourette'spatients and a g......isorders and developing more specific therapies to treat the disease and notjust the symptoms." Steven R. Brant, M.D., director of the IBD Genetics Laboratory at Johns Hopkinsand senior author of the study, said "Identifying the location of IBD genes isan important step toward the goal of preventing Crohn'......strongenough to fly out of it. "Historically, we'd treat a marsh like this one near the school with DDT,and that worked great. Later, we'd treat it with chlordane, and that workedgreat. The problem is DDT and chlordane stay in the muck forever, ...