Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
...mising, but it was early days yet and the Phase II trial in Germany was designed to verify whether a similar treatment to that used in the mice could alter the course of minimal clinical disease in patients. The lycopene product used (LycoVit)[3], has received the Generally Recognized as Safe (GRAS) status...New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
...versity of Medical Sciences in Iran, are running a trial of its use in newly diagnosed APL patients who hav...er a third cycle of treatment. Six patients in the trial have died. APL accounts for around 10% of acute myeloid leukaemias and affects an estimated 20,000 ...Phase II trials of second-generation antisense cancer drug planned following successful early study
...va today (Wednesday 29 September) that the Phase I trial was unique in that the clinical research team was ...y patients. Said Dr. Chi: "We designed the Phase I trial in such a way that we could identify the biologically active dose in the tumour tissue. Being able t...Award winning researchers reveal potential new role for Glivec
...achieved in eight out of 10 patients in a Phase II trial either through imatinib alone or imatinib plus surgery. The research team are preparing to present their findings to regulatory bodies for approval for imatinib's use as a treatment for unresectable DFSP when it exhibits a particular genetic profile....Trial shows which brain cancer patients benefit from temozolomide
...been tested successfully so far in a seven-country trial organised by the EORTC and National Cancer Institu... She said that the study was the first randomised trial to test MGMT methylation status in a large patient population. "The test will provide the opportunit...16th EORTC NCI AACR Symposium 'Molecular Targets and Cancer Therapeutics'
...e, underpinning epidemiological evidence. Phase II trial in patients now under way. * Dr. Olivier Feron: A ... trial. * Professor Eric Van Cutsem: International trial results shows way to measure success of centuximab (Erbitux). Randomised study now under way Chairma...16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
...ukaemia *Dr Kim Chi: Successful results of Phase I trial of the first second generation antisense cancer drug - phase II getting under way * Dr Grant McArthur: Award winning researcher reveals potential new role for Glivec in a soft tissue cancer Chairman: Professor Jaap Verweij (EORTC chairman of confere...Yale digital diagnostic technology is basis of new company, HistoRx Inc.
...ntial to significantly reduce the risk of clinical trial failure and move new drug candidates through the development process more quickly. ...Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
...rapy agents are thought to be nearing the clinical trial stage. It is well-known that the human (and animal) gut is full of mostly beneficial bacteria. In IBD and other diseases researchers have taken an approach that reintroduces these positive bacteria, allow them to repopulate the gut and quite often th...New treatment for fibromyalgia
...serotonin and norepinephrine. In a recent clinical trial conducted for the treatment of fibromyalgia--one of the largest ever--duloxetine was shown to reduce pain and improve a range of disease symptoms, significantly and safely. The results, published in the September 2004 issue of Arthritis & Rheumatism...The impact of genetic variations on the treatment of early rheumatoid arthritis
... early stages of RA who participated in a clinical trial comparing weekly methotrexate, 10 milligrams twice...proved dose for RA). The results of this clinical trial have been previously published (Bathon et al. New Engl J Med 343:1586-1593, 2000). Researchers e...Final Alert: 16th EORTC NCI AACR Symposium
...results underpin epidemiological evidence patient trial now started International trial finds acne-type side effect predicts effectiveness of new targeted treatment Laboratory tests show ...New fumigant to replace gas that damages ozone layer
...dy received interest from a number of countries to trial and introduce applications of EDN....Essential smell gene may provide key to new insect repellents
...osshall adds. "Most insect repellents are based on trial and error, or folk remedies. Now we have a scientific, rational basis for designing insect repellents." An anomalous smell receptor The sense of smell is very direct. In order for humans or fruit flies to smell bananas, for example, molecules from ...OHSU-VAMC study sheds light on estrogen's benefit for MS
...ramatically during pregnancy. And a small clinical trial at the University of California, Los Angeles, showed estriol, the estrogen hormone produced during pregnancy and available as an oral therapy, showed "some benefit" for MS patients. "However, long-term estrogen therapy has potential side effects," an...First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
...boratory abnormalities. This FDA-approved Phase I trial was initiated in adults as a first step, prior to future testing in children and then infants--the ultimate target population, said Jerry Shenep, M.D., member of the department of Infectious Diseases and a co-author of the paper. "The St. Jude team ...Institute for OneWorld Health nominated for the 2004 World Technology Awards
...eWorld Health is in the final stages of a clinical trial to develop a new cure for visceral leishmaniasis (VL), a parasitic disease that kills approximately 200,000 people each year, mostly in the Indian subcontinent. The company will seek regulatory approval in India next year, and finalize distribution ...Retroviral gene therapy? ASLV, HIV, and MLV show distinct target site preferences
...fter participating in an experimental gene therapy trial in 1999. In another case, two young boys who received gene therapy for the severe immunodeficiency disorder known as "bubble boy disease" developed leukemia-like symptoms 30 months after treatment. In this case, the viral vector inserted itself near ...Brain's reward circuitry revealed in procrastinating primates
... monkeys made progressively fewer errors with each trial as the reward approached, with the fewest occurring during the rewarded trial. Previous studies had also traced the monkeys' ability to associate the visual cues with the reward to the rhinal cortex, which is rich in dopamine. There was also reason t...Jefferson scientists find gene expression pattern may predict behavior of leukemia
...oce, the results need to be verified in a clinical trial screening thousands of patients. Dr. Croce and his colleagues had previously shown that deletions in miRNA genes were involved in B-cell CLL. They also had reported that human miRNA genes are frequently located at sites of the genome that are altere...