Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
...e chromosome ends from damage that otherwise would trigger apoptosis--the cell's self-destruct program. Most cancers activate telomerase to maintain telomeres in order to protect their chromosomes and ensure the cells survive and multiply. However, a minority of cancers use a poorly understood mechanism ca...A novel, safer strategy for regulating gene expression
...ere are concerns that the activating protein could trigger the immune system and cause unwanted side effect. In addition, the current systems work with only a handful of specific drugs. In contrast, the ribozyme-based system can, in principle, be designed to regulate genes using any drug, or any chemical cha...Amyloid fibers sprout one step at a time
...ion infections, these abnormal, insoluble proteins trigger protein clumping, producing a plaque that can kill brain cells. In humans, clumping causes fatal brain-destroying diseases such as Creutzfeldt-Jakob disease and kuru; in animals it causes bovine spongiform encephalopathy (mad cow disease) and scrapie...Algal contact as a trigger for coral disease
...t common macroalgae, Halimeda opuntia, is shown to trigger a particularly virulent disease known as white plague type II. In the Caribbean, a large number of coral colonies on which this alga was transplanted developed white plague whereas unexposed colonies did not. In addition, the plant was found to be a...A probable cause for high blood pressure identified - shows links with diabetes
...lecule in the body was binding to this receptor to trigger this reaction. Now that we have identified this substance, we can begin to look at ways of blocking its action. We also found that excessive accumulation of this molecule in the pancreas will impair insulin release, thus it is possible that this mole...Molecule awakens and maintains neural connections
... a neuron. Dendrites receive chemical signals that trigger nerve impulses in the form of neurotransmitters launched from neighboring neurons. Growth of new dendrites can therefore increase the connection between neurons. Changes in the strength of connections, known as long-term potentiation, allow the brain...Researchers identify distinctive signature for metastatic prostate cancer
...ate target cell and activated the right pathway to trigger cancerous growth." To relate their findings to the metastatic process, the researchers tested samples of metastatic prostate cancer from men who had died of the disease. They found a uniformly high level of Hedgehog activity in these tissues, compar...Sugar-coated sea urchin eggs could have sweet implications for human fertility
... those sugars attach to proteins in sperm cells to trigger reproduction. "They are different but they probably do exactly the same thing as sea urchin eggs," she said. She noted that proteins are much better understood than sugars, so the role of the proteins in sperm can be studied relatively easily. Figu...Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
...ll surface glycosaminoglycans (GAG) is believed to trigger IBD, and their enrichment has been proposed for treatment. Yedgar's lab has designed and synthesized multi-functional anti-inflammatory drugs (MFAIDs) that address both these needs, by linking PLA2-inhibiting lipids to GAG. They report that MFAIDs, g......thing like Compound 3, it would cause TNF alpha to trigger apoptosis in the cells that cause joint and tissue damage. Thus, the secondary inflammation from these cells would be prevented." However, he said, further studies in his laboratory will concentrate mainly on using Compound 3 as a prototype treatmen...Optimizing protein's 'death domain' halts leukemia in laboratory study
...reinforced coil was able to enter cancer cells and trigger apoptosis, or self-destruction, of those cells. The most dramatic success occurred in mice transplanted with leukemia cells that gave off a glow when the mice were injected with a light-emitting substance, luciferin. After they administered the rein...Molecular staples shape a cancer killer
...ids -- could insinuate itself into cancer cells to trigger their suicide. "Our goal was to modify the natura...alpha-helical shape, bound to the right protein to trigger apoptosis, and resisted degradation by proteases. They also found that SAHB specifically triggered t...Essential smell gene may provide key to new insect repellents
... essential to the series of molecular signals that trigger perception of a scent. "The reason this is really important is that we've reached an impasse in the fight against bad insects," says Vosshall. "We have DEET, but it has to be reapplied, you use large amounts, and every part of the skin has to be cov...How an insidious mutation fools DNA replication
...nd that would clog the Cheerio. Such malformations trigger a repair mechanism to correct the mismatch. The r...h leads to errors in the cell's machinery that can trigger the uncontrolled growth of cancer or the death of cells in aging. However, researchers have long kno...Streptococcus infects humans by thwarting blood clotting
...e bacterial products, as well as our immune cells, trigger the human clotting system, which evolved in part as a defense against such infection," said Ginsburg. "This system produces clots in the blood vessels around the infection, closing the highways that the bacteria would use to spread. However, the bact...New understanding of the machinery of flinching
...nd other researchers had shown could be induced to trigger flinching by electrical stimulation. However, Graziano and Cooke sought to test the hypothesis that the polysensory zone controls the natural behavioral flinch; motor cortex is usually not thought to control full, natural movements. To do this, they ...New clues to hereditary blinding disease found
...odopsin, a light receptor protein in the eye, can trigger retinitis pigmentosa (RP), a degenerative disease that leaves many patients legally blind by the age of 40. The findings parallel similar progress in harnessing essential trace metals in the body to treat several neurodegenerative diseases including...Putting energy into heart protection
...ls from consuming their source of energy, ATP, and trigger them to begin to produce ATP. This is done by inducing cells to stop any biochemical pathways that use energy and by turning on processes that take up glucose and free fatty acids from their surroundings in order to rebuild their ATP reservoir. The...JCI table of contents, 16 August, 2004
...ls from consuming their source of energy, ATP, and trigger them to begin to produce ATP. This is done by ind... with the immune system's natural killer cells and trigger them to destroy the tumor cells. Jennifer Wu and colleagues, at the University of Washington, now in...... with the immune system's natural killer cells and trigger them to destroy the tumor cells. Jennifer Wu and colleagues, at the University of Washington, now investigate how prostate cancers evade this anti-tumor defense strategy. The researchers found that MIC-expressing prostate cancer cell lines w...