Tag: "trigger" at biology news

UNC researchers identify protein crucial to gene silencing

... such methylation might not be enough by itself to trigger gene silencing. The newly discovered murine regulatory protein is called "mAM." Its human equivalent, or homologue, is "hAM." Stimulated by this protein, the state of methylation of lysine-9 on H3 that's produced by the enzymatic subunit is made mor...

Fishing for photos of rare or unknown deep-sea creatures with an electronic jellyfish lure

...ls nearby when they give off bioluminescent light, trigger a video camera to record the light being produced, then turn on a red light out of the animals' normal vision range to take illuminated footage. The system can also be programmed to film surrounding areas at scheduled intervals, for instance when the...

Emory scientists track down immune sentinel cells with gene gun

...is rearranged by an external signal. They shot the trigger signal DNA encoding a specialized bacterial enzym... the mice. All the cells in the skin received the trigger signal, but only the dendritic cells migrated to the draining lymph nodes. Dr. Jacob estimates that ...

Northwestern's Cancer Genetics Program pinpoints gene that increases cancer risk by 26 percent

...d ovarian cancers," said Dr. Pasche. Altered genes trigger all cancer. "Most cases of breast, ovarian and colon cancers are caused by damage to the genes that builds up over a lifetime, but some people are born with a high risk of the disease," explains Pasche. "When inherited, the TGFRB1*6A gene makes peo...

Study provides new insights into emerging theory of gene regulation

...and off the DNA at specific times and locations to trigger the activation of genes." The so-called "histone code" theory of gene regulation, advanced by C. David Allis, Ph.D., at the University of Virginia, and others, suggests that complex, interdependent modifications to the histones are responsible for co...

Leishmania mutant provides insight into disease and may lead to a vaccine

...sed immune system, the parasites become active and trigger leishmaniasis. In fact, the disease is a common complication of AIDS in endemic regions including the Mediterranean basin and Southern Europe. Persistent parasite infections are usually difficult to study, according to Beverley, because it can take s...

Molecules discovered that extend life in yeast, human cells

...ly calories) may be one of many mild stresses that trigger beneficial effects, a phenomenon called hormesis. To explain their new findings, the researchers propose that plant polyphenols, which increase in response to stressful conditions, cue organisms to prepare for impending harsh conditions by switching ...

Brain links non-food images with eating -- But only when hungry, study suggests

...tioning," may extend to other substances that also trigger the brain's reward circuitry, Gottfried said. The ease with which we seem to associate pleasure-giving substances with other items supports the idea that one reason it's so hard for addicts to stay clean is that the smallest signs can bring back the ...

Tipping the balance of prion infectivity

...ion infections, these abnormal, insoluble proteins trigger protein clumping that can kill brain cells. In humans, clumping causes fatal brain-destroying human diseases such as Creutzfeldt-Jakob disease and kuru, and in animals it causes BSE and scrapie. In the yeast cells used as research models by Weissman...

Stem cell defects are key to Hirschsprung's disease

...cialized nerve cells in the large intestine, which trigger contractions to push feces through the colon and out the rectum. The result is chronic constipation and intestinal obstructions requiring surgery, sometimes immediately after birth. Scientists have known for years that Hirschsprung's is a genetic dis...

Development of hair depends on development of the hair channel

...y pinpointed a protein called GATA-3 as a possible trigger of hair channel development. Based on its location within the hair and the timing of its appearance, GATA-3 stood out as a strong candidate for instructing skin stem cells to transform into hair channels instead of hair. Analyzing mice previously eng...

Name that tune

...how how songs that birds have learned to recognize trigger responses both in individual neurons and in popula...otifs in an otherwise unfamiliar song is enough to trigger recognition." To examine the neural mechanisms associated with auditory memory, Gentner and Margolia...

Fears of second-hand smoke confirmed

...r HFL-1 (fibroblast) cells, and is most likely the trigger leading to the development of pulmonary emphysema in smokers' lungs. Their findings confirm the fears of many in a work and social environment that exposure to second-hand smoke can lead to a deadly and debilitating disease. Background Among the dif...

Gene helps determine whether the stresses of life push you into depression, Science study says

...r strings of unfortunate events are most likely to trigger clinical depression in people with the least protective version of the serotonin transporter gene, according to this research team led by Avshalom Caspi and Terrie Moffitt. Depression, as defined by the authors, is a period of at least two weeks in t...

Brain stem cells are not rejected when transplanted

...o a transplantrecipient's immune system and do not trigger the immune system to rejectthem. These results, published in the July issue of Stem Cells, indicatethat using central nervous system stem cells in transplants for diseases ofthe eye (which is part of the brain), brain, and spinal cord, may eliminatet...

OXiGENE announces launch of ophthalmic clinical trial at The Johns Hopkins School of Medicine

... that leak blood and fluid into the retina and can trigger a sudden and severe loss of vision. An article in the June 2003 issue of Nature Reviews Drug Discovery estimates that, as the population ages, the number of wet AMD cases will grow fivefold. CA4P, which is derived from the bark of the South African...

Salk scientists identify pathway that determines when plants flower

...oup of phytochromes, photoreceptors in plants that trigger the "shade-avoidance response." Using the common mustard seed plant Arabidopsis-the first plant to have its entire genome sequenced by a multinational consortium that involved Salk professor Joe Ecker and other researchers-Chory and Cerdn identified ...

Getting closer

...dy fights harmful antigens foreign molecules that trigger an immune response. The team successfully simulated a mutation process that diversifies the proteins, or antibodies, responsible for immunity a phenomenon known as somatic hypermutation. This process enables the body to fight off a wide range of dis...

Structure of HIV-neutralizing antibody solved

...ts with a template to design an antigen that would trigger the body to produce 2G12. Antigens are molecules that the immune system recognizes as foreign; they stimulate the immune system to produce antibodies to combat invading microbes. The scientists believe that it might be possible to design an antigen t...

Distinctive genetic program guides breast cancer's deadly spread

...d genes enabled tumor cells to home in on bone, to trigger growth of blood vessels, and to recruit bone cells in the metastatic process, said Massagu. Furthermore, he said, the bone-metastasis genes were distinct from those in cells that metastasize to the adrenal gland. "We also asked the question of whethe...

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