Tag: "triggers" at biology news

As autumn approaches, this chickadee's brain begins to expand

...- and we're interested in finding out what exactly triggers it." Songbirds are the first species of vertebrate in which brain growth during adulthood has been found to occur, Saldanha says. By studying neurogenesis in the black-capped chickadee, Saldanha hopes to learn how hormones help guide the brain's deve...

Drug developed for rare disease may help millions more as treatment for cancer, autoimmune diseases

...growth factor beta, or TGF-beta, the response that triggers the connective tissue growth. Additionally, studie... or tumor necrosis factor alpha, the response that triggers inflammation. "When an organ is injured, the body overreacts, and doesn't properly regulate. This ca...

Mouse, stripped of a key gene, resists diabetes

...n insulin binds to the cell's insulin receptor, it triggers a cascade of events " that enables the animal to successfully regulate levels of blood sugar. "There are lots of steps involved in the process, and in the case of type II diabetes things go wrong in some of those events," Ntambi says. "What we found ...

Honeybee gene find ends 150-year search

...from each parent, that form an active protein that triggers female development. Unfertilized eggs, which have only one copy of csd from the mother, default to being males. In 1845, a Polish parish priest called Johann Dzierzon proposed that male bees have no fathers: They develop from unfertilized eggs, while...

'MicroRNAs' control plant shape and structure

... or turning off expression of specific genes, that triggers development of plant parts with the proper shape. "In this study we've demonstrated the real life consequences of a microRNA, showing how regulated destruction of a set of messenger RNA targets controls the shape of a plant's leaf," said ...

How AIDS destroys immunity

...did not actually show how the AIDS virus' vpr gene triggers ATR to halt the replication of CD4+ white blood cells, but instead showed how vpr triggers ATR in human cervical cancer cells known as HELA cells, stopping replication of the cancer cells. Th...

Development of hair depends on development of the hair channel

...he formation of immune cells, called T cells, also triggers stem cells to become hair rather than skin. Called Lef1, this protein is a component of the Wnt signaling pathway. In their recent study at Rockefeller University, the Fuchs lab noted a similar relationship between the hair channel and T cells: GATA-...

Endostatin promising treatments for AIDS-related cancer

...on-causing cytokines. This production of cytokines triggers an increased production of primitive cells called endothelial progenitor cells cells that help repair damaged blood vessels. But in the case of HIV-positive people, this rampant production of endothelial cells can give rise to KS tumors. Mallery bel...

Salk news: gene therapy for Lou Gehrig's disease

...scle mass. The researchers demonstrated that IGF-1 triggers a molecular pathway that appears to preserve motor nerve function. When the receptor for IGF-1 is activated, an enzyme called Akt has a phosphate molecule added to it (a process called phosphorylation). The Akt enzyme is activated and helps block th...

Researchers identify new cause of genomic instability

...the H2AX protein -- called "haploinsufficiency" -- triggers genomic instability and cancers could be highly significant, said Alt. Such a class of mutation would not have been readily detected in most searches for genes that suppress tumors in humans. Indeed, Bassing discovered that tumors in these mice still...

Stem cell death gives clue to brain cell survival

A signal that triggers half the stem cells in the developing brain to commit suicide at a stage where their survival will likely do more harm than good has been identified by researchers at the Medical College of Georgia and the University of Georgia. Identifying the facto...

Physics tip sheet #36 - July 30, 2003

... which an increase (or decrease) in blood pressure triggers a decrease (or increase) in heart rate. Their results mark the first demonstration of a functional link between fractal noise and the sensitivity of the physiological control system. Journal article: Available to journalists on request 8) Natural na...

Protein that fights bacteria and viruses cloned by Scripps scientists

... and other proteins such as Trif. This recognition triggers the immune system, which responds with a multi-stage biochemical defense. The first stage typically involves the innate immune system and its army of white blood cells, like macrophages, which engulf and destroy pathogens. The macrophages also fight ...

Link between neuronal calcium channel, mutated gene that causes Huntington's disease identified

...y new areas for treatment of the disease." Calcium triggers the release of neurotransmitter signals, a process that initiates communication between neurons in the brain. But too much calcium, Dr. Bezprozvanny said, kills neurons. Researchers hope the discovery leads to the development of drugs to block the ac...

University of Rochester scientists test new method to attack cancer

...a healthy cell turns cancerous, a genetic mutation triggers the production of telomerase, which restores the telomeres to normal length. The restored telomeres enable the cell to divide, unchecked, thousands of times instead of the usual 50 to 100. Over time, a few cancer cells can multiply into a golf-ball-s...

Mutant gene found to cause early ovarian failure in mice

... about - that is, the mechanism that constrains or triggers the activation and maturation of the egg," says DePinho. The findings grew out of an experiment in which the researchers created mice lacking both copies of the FOXO3a gene, which belongs to the forkhead gene family. As transcription regulators, or s...

Researchers identify key molecular signal in plant pollination

...n nervous system, is a key signaling molecule that triggers plant reproduction. "When a pollen grain is deposited on the surface of a flower, it's like a speck of dust landing on the skin," said Preuss. "The fertilization process is unlike that in animals, in which the sperm swim through a well-defined cavity...

Braunschweig Prize 2003 for Molecular Cancer Therapy

...ally known as Glivec. Glivec blocks a protein that triggers the uncontrolled reproduction of white blood cells. "The name Brian Druker has become synonymous with a breakthrough in cancer therapy," said Braunschweig's mayor and chairman of the jury, Dr. Gert Hoffmann on the 8th of July after the vote of the co...

A two-lane road to ruin

...nd B, two of these proteases, are highly efficient triggers of intracellular cell death inducing (cytotoxic) cascades. The same beneficial effector molecules, however, can also turn their powerful energies against transplanted organs, grafted stem cells and self-tissues in autoimmune disorders and are then de...

Salk scientists identify pathway that determines when plants flower

...ory and Cerdn identified the specific protein that triggers flowering in response to suboptimal light conditions. "We screened for mutant versions of Arabidopsis to identify the protein and the signaling pathway that leads to flowering in shade conditions," said Cerdn. "We discovered that the protein, called...

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