Tag: "triggers" at biology news

Scientists discover how to grow cells that suppress immune responses

...lls. The investigators next want to study how CD46 triggers production of IL-10 and to better define the population of cells that give rise to Tr1 cells. They also want to explore how viruses, including those that cause measles, meningitis and herpes, interact with CD46. Its tempting to think that these path...

Too much oxygen on the cell biology bench? New study suggests so

...turally rich in oxygen that it triggers cellular stress, said Sen, who directs the Laboratory of Molecular Medicine at Ohio States Davis Heart and Lung Research Institute. When Sen and his colleagues exposed m...

Researchers discover protein defect linked to gastrointestinal cancer

... researchers have discovered a protein defect that triggers some cases of a deadly gastrointestinal cancer. The defective protein, a mutated form of the enzyme platelet-derived growth factor receptor alpha (PDGFRA), may serve as a target for new "smart-bomb" therapies against gastrointestinal stromal tumors (...

$24-million grant funds local researchers to create encyclopedia of the innate immune system

...on" pathways through which this immune recognition triggers the innate immune response. The researchers will take a "systems biology" approach to identifying all these players. Dubbed "21st-century biology," the relatively new field of systems biology melds mathematics, computer modeling, and the new techniqu...

OXiGENE announces commencement of Phase I/II clinical trial of Combretastatin A4 Prodrug

... formation of aberrant blood vessels. The compound triggers a change in the shape of endothelial cells lining a tumor's blood vessels. This in turn blocks the flow of blood to the tumor, depriving it of oxygen and nutrients. The compound is a synthetic form of CA4, a natural substance found in the bark of the...

Cocaine harms brain's 'pleasure center,' addict study finds

...opamine neuron health. Dopamine, Little explains, triggers the actions required to repeat previous pleasures. It's not only involved in drug users' "high" it helps drive us to eat, work, feel emotions, and reproduce. Normally, when something pleasurable happens, dopamine neurons pump the chemical into the g...

OXiGENE announces phase II clinical trial of lead anti-tumor compound in thyroid cancer

...e formation of aberrant blood vessels. Thecompound triggers a change in the shape of endothelial cells lining atumor's blood vessels. This in turn blocks the flow of blood to thetumor, depriving it of oxygen and nutrients. The compound is asynthetic form of CA4, a natural substance found in the bark of theSou...

Study of possible anticancer drug reveals new mechanism of gene regulation

...hers conclude that when rapamycin inhibits TOR, it triggers a variety of responses, including stress and starvation responses. Together, these actions probably cause the cells to stop proliferating. These insights into rapamycin's action must now be verified in human cells....

Firefly molecule could quickly shed light on how well new drugs work

...ble through the use of luciferase, the enzyme that triggers a chemical process that lights up the tails of fireflies. The light-emitting process, called bioluminescence, has been used for several years in biomedical research -- but with the glow always turned "on" to produce a constant stream of light. The U...

Canadian scientists unlock secret of calcium waves in cells

...al response-for instance, an increase in glutamate triggers memory. The translation by the IP3 molecule is accomplished by setting waves of different calcium levels within the cell, with the receptor regulating the ebb and flow of these calcium waves. The process is critical to normal brain function, playing ...

Scientists discover gene 'signature' for tumor's tendency to spread

...a common and feared event in cancer patients, what triggers it is poorly understood. Cancer cells must undergo a series of changes to become metastatic: they have to acquire the ability to grow while unattached to any tissue, they need to bore through vessel walls to reach the bloodstream or lymphatic system,...

Critical therapeutics is awarded U.S. patents for methods to diagnose and treat inflammatory disease

...ytokine cascade," or overproduction, of HMGB1 that triggers sepsis and other inflammatory diseases. U.S. patent number 6,448,223 B1, "Antagonists of HMGB1 for Treating Inflammatory Conditions," covers a method of administering antibodies to treat the inflammatory illness. These antibodies neutralize the pro...

Researchers find genes connected to seasonal reproductive clock in hamsters

...e. "The short days of winter triggers a timer that shuts off the reproductive cycle," Prendergast said. "But the timer ends in mid-winter and tells the brain to stop responding to the short days. That's when the reproductive ...

UC Berkeley scientists detail neural circuit that lets eye detect directional motion

...st cells. The cumulative effect is a stimulus that triggers the ganglion cell to send a signal to the brain. When a target moves in the "null" direction, starburst cells inhibit firing and also veto the excitation from bipolar cells. The net effect is strong inhibition and no firing of the directionally sele...

Researchers identify cause of aggressive childhood cancer

... model of a new type of tumor suppressor gene that triggers a rapidly advancing cancer that affects children. The discovery of the fast-onset cancers that result from inactivation of the gene and the technique used to generate the model will likely prove useful in studying genes involved in other forms of can...

First results from novel anti-angiogenic drug trial in patients

...thway and preventing the activation of a gene that triggers melanin activity. He concluded that if the drug's activity held up in further trials it had the potential to be a potent new weapon. "It is one of the first angiotoxic drugs with anti-tumour effects. In fact, we had too much effect in higher doses in...

Clock cues: Cellular sensing, metabolism research wins Amersham Biosciences and Science Prize

...wich, UK, demonstrated that when an invading virus triggers a silencing response at a local point in the host plant's genome, a previously unknown "signal" spreads the silencing throughout the rest of the genome. Voinnet also showed that viruses encode proteins that fight against silencing, uncovering an arms...

Getting at the roots of terrorism

...ar single-resource root of policies have served as triggers in the Middle East but not in other regions. The active suppression by national governments of guerrilla movements such as the Shining Path in Peru is probably significant as well. Prudent course I am convinced that the prudent course for the Unite...

UT Southwestern scientists discover link between infections in mothers and brain injuries in babies

...s is figuring out where the damage begins and what triggers it," said Dr. Jeffrey Perlman, professor of pediatrics at UT Southwestern and senior author of the study. "Our study opens a new pathway of understanding, but we still don't have all the answers." The study reveals the link between brain injury that ...

Model for common type of cancer developed by UCLA scientists

...The idea is to interrupt the cell signal before it triggers the genetic mutation that causes the cancer to begin to grow. "I think we may have identified an important mechanism that links certain signaling pathways with the causation of certain cancers, in this case in the immune system but perhaps in other p...

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