Study at TSRI links dozens of proteins to several rare muscle and nerve degeneration diseases
La Jolla, CA. September 2, 2003--A team of scientists at The Scripps Research Institute (TSRI) has identified more than 50 previously unknown proteins and associates several of them with rare human muscle and nerve degeneration diseases. The team is publishing their findings this week in the journal Science.... ...Led by TSRI Professors Larry Gerace and John R. Yates III, the team used a techniq...Scientists at TSRI create new strain of yeast with 21-amino acid genetic code
Henry Ford revolutionized personal transportation by introducing an unusual car design onto the auto market and by embracing factory mass production of his "Tin Lizzie."... ...Now a team of investigators at The Scripps Research Institute (TSRI) and its Skaggs Institute for Chemical Biology in La Jolla, California is introducing revolutionary changes into the genetic code of organisms like yeast t...Towards an AIDS vaccine: unusual antibody that targets HIV described by scientists at TSRI
A group of scientists from The Scripps Research Institute (TSRI) and several other institutions has solved the structure of an antibody that effectively neutralizes human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS). ... ...The antibody binds to sugars on the surface of HIV and effectively neutralizes the virus because of its unique structure, whic...TSRI scientists show that rare genetic mutations increase susceptibility to sepsis
A group of researchers from The Scripps Research Institute (TSRI) have discovered rare genetic mutations in a subset of people who come down with a particular kind of severe sepsis, an acute and often deadly disease.... ...These rare mutations in a human gene called TLR4 lend susceptibility to meningococcal sepsis, which strikes over 2,500 people a year in the United States. About half of those w...Expanding the genetic code--TSRI scientists synthesize 21-amino-acid bacterium
Scientists at The Scripps Research Institute (TSRI) report in an upcoming article in the Journal of the American Chemical Society their synthesis of a form of the bacterium Escherichia coli with a genetic code that uses 21 basic amino acid building blocks to synthesize proteins--instead of the 20 found in nature....... This is the first time that anyone has created a completely autonomous organis...TSRI professor named industry pioneer in one of the top ten technologies that will change future
The Scripps Research Institute today announced that Professor James Paulson, Ph.D., has been chosen as a global leader in the field of glycomics by Technology Review, The Massachusetts Institute of Technology's magazine of innovation. The magazine's February 2003 issue identifies ten emerging technologies it says will change the world. It is on newsstands January 21 and online now at .... ...Th...'Binary' enzyme created by TSRI scientists demonstrates Darwinian evolution at its simplest
Two scientists at The Scripps Research Institute (TSRI), Research Associate John S. Reader, D.Phil, and Professor Gerald F. Joyce, M.D., Ph.D., both of the institute's Department of Molecular Biology, have succeeded in creating an enzyme based on a "binary" genetic code--one containing only two different subunits. ... ...This research, described in the latest issue of the journal Nature, demonstr...Gene responsible for rewinding body's 'clock' described by scientists at TSRI
A group of scientists at The Scripps Research Institute (TSRI) and the Genomics Institute of the Novartis Research Foundation (GNF) has demonstrated that the gene Opn4, which codes for the protein Melanopsin, is the elusive pigment gene that captures light and keeps your body tuned to a daily cycle--called a circadian rhythm. ...... "This is the key protein in the eye that sends signals to the cl...Scientists at TSRI identify thousands of proteins associated with deadliest form of malaria
Two scientists at The Scripps Research Institute (TSRI) led a collaborative effort involving 18 researchers at half a dozen laboratories in the United States and Great Britain to determine the "proteome" of the most deadly form of the malaria pathogen-- Plasmodium falciparum....... This study, in the current issue of the journal Nature, accompanies an article detailing the completion of a major s...Scientists at TSRI receive $9.6 million to develop treatment for common cause of vision loss
A group of researchers at The Scripps Research Institute (TSRI), who recently discovered a potent inhibitor of angiogenesis, a process implicated in cancer and one of the leading causes of blindness in the United States, have been awarded a five-year, $9.6 million grant from the National Eye Institute to study this inhibitor further and develop ways to use it in patients with neovascular eye dise...Adult stem cells selectively delivered into the eye and used to control angiogenesis at TSRI
A team of researchers from The Scripps Research Institute (TSRI) has discovered a way to use adult bone marrow stem cells to form new blood vessels in the eye or to deliver chemicals that will prevent the abnormal formation of new vessels....... This technique, which involves injecting the stem cells into the eye, could potentially be used to stimulate vessel growth and address inherited degenera...Folding upon binding: unique protein activation mechanism found by scientists at TSRI
A group of scientists at The Scripps Research Institute (TSRI) have solved the structure of two critical human proteins that are normally unstructured in the cell, but fold synergistically so that together they form an active biological structure.... ...The structures themselves may one day lead to new therapies, since the proteins are important regulators of genes essential for development and r...Researchers at TSRI turn viruses into enhanced nanochemical building blocks
Using a combination of chemistry and molecular genetics, researchers at The Scripps Research Institute (TSRI) and The Skaggs Institute for Chemical Biology have found a way to attach a wide range of molecules to the surface of a virus, essentially enhancing the virus with the properties of those molecules.... ...In the current issue of the journal Angewandte Chemie, scientists Qian Wang, Tianwei...Nanoencapsulation: Chemists at TSRI discover a new and simple way of controlling reactions
A group of scientists at The Scripps Research Institute (TSRI) were able to demonstrate complex system behavior among small, reacting organic molecules by putting them in and out of a nanocapsule....... In the current issue of the journal Nature, a report from a group led by Julius Rebek, Jr., Ph.D., demonstrated that they could achieve chemical amplification (speeding up the reaction as it proc...TSRI scientists clone gene that regulates circadian rhythms in plants
. La Jolla, CA, August 4, 2000 Scientists at The Scripps Research Institute (TSRI) have cloned a gene that regulates circadian rhythms in plants, providing an increased understanding -- on a molecular level -- of the processes that enable organisms to anticipate and adapt to daily variations in the environment. According to Steve Kay, Ph.D., Professor of Cell Biology and an author of the study,...New Study By TSRI Scientists Sheds Light On Viral Clearance In Acute Hepatitis B Infection
.La Jolla, CA. April 30, 1999 -- A study published in today's issue of Science by.Drs. Luca G. Guidotti and Francis V. Chisari at The Scripps Research Institute.(TSRI) demonstrates a new paradigm in viral immunology, namely that the immune.system can cure viral infections without destroying the infected cells. Until.now, scientists believed that viral clearance was due to the destruction of.infe......La Jolla, CA - February 6, 1998 -- For years scientists have studied...angiogenesis, the process whereby new blood vessels are formed from pre-existing...ones. Except in a few special circumstances, it does not occur in the normal...adult. However, angiogenesis plays a key role in a number of diseases associated...with new blood vessel growth such as cancer, diabetic retinopathy, macular...de...