Is there an unexpected price for late night high tech excitement?
... were collected by using cotton wool and a plastic tube at 2300 (before commencement of the task) and at 0200 (after completion of the task). Rectal temperature was recorded at two-minute intervals during each task. Heart rate, EEG, and subjectively rated sleepiness were recorded before the start of each ...Pancreatic cancer linked to errant reactivation of embryo cell pathway
...ound that when Notch signaling was blocked in test tube studies, they were able to prevent the early cellular changes leading to pancreatic cancer. The investigators are now attempting to block Notch signaling in mouse models in hopes of developing a strategy for human pancreatic cancer prevention. "Cur...'Reverse CPR' performed on back could better restore blood flow
...ng brain activity tests, physical exams, breathing tube insertions and placement of central lines in blood vessels. "The standard monitoring and treatment tools of the ICU present significant barriers to reverse CPR right now," he says, "but even so, each patient in our study was turned over by only a fe...Cigarette smoke linked to low folate levels
...re in other folate-related diseases such as neural tube defects and colon cancer," Mannino and colleagues say. The study included 15,564 adults ages 17 and older who received blood tests for cotinine, a nicotine byproduct, and folate. The people were also asked about their eating and smoking habits. Older...Strategies to boost womens multivitamin use fall short
... has been shown to reduce the occurrence of neural tube defects, which affect about 4,000 pregnancies and ...egnant, and to determine what proportion of neural tube defects occurs from inadequate folic acid consumption since the U.S. food supply was fortified with ...First proof that polycystic ovarian syndrome is more than twice as common in lesbian women
...ed that there was a similar incidence of Fallopian tube disease in both groups. "The importance of this finding is to make clinicians aware that sexually transmitted diseases are just as prevalent in lesbian women as in heterosexual women. Previous studies have shown that at least 70% of lesbian women hav...New technique for sorting sperm could improve fertility treatment
...e that hasn't changed much since the initial "test tube babies." "It has potential to provide a solution to a specific problem, but maybe more importantly it could represent a new integrated system where microfluidics is used to sort sperm, and divert those sorted sperm to eggs. Potentially, we could crea...Researchers identify key molecular signal in plant pollination
...cting control signals that likely guide the pollen tube on its crucial journey. In an article published in.... Instead, this pollen grain somehow has to grow a tube from the stigma of the flower, digesting tissue to burrow all the way inside to where the eggs are. ...Researchers identify molecular signaling system that is crucial for plant fertility
... role in plant reproduction, guiding growth of the tube that transports sperm from a pollen grain on a flo... the surface of a flower, it somehow has to grow a tube from the stigma of the flower, past several different cell types to where the eggs are, digesting ti...Salt controls size of DNA structures, could improve gene therapy
... nature of DNA particles all the way from the test tube to the cell."...Study shows enzyme helps guard against Alzheimer's disease
...h Hunter first identified the enzyme in 1995, test tube studies found that Pin1 has the ability to promote dephosphorylation of tau, restoring it to its original shape. This finding led Lu and his colleagues to hypothesize that Pin1 might also be able to prevent tangle formation and resulting neurodegener...Folic acid may have no immediate impact on Down Syndrome
...y to dramatically decrease the incidence of neural tube defects (e.g. spina bifida) in newborns. Dr. Joel Ray, of the Departments of Medicine at U of T and St. Michael's Hospital, and co-researchers decided to examine the prevalence of Trisomy 21 (commonly known as Down Syndrome) following the introductio...Common nutrients fed to pregnant mice altered their offspring's coat color
...taple of prenatal vitamins, used to prevent neural tube defects like spina bifida. Yet excess folic acid could methylate a gene and silence its expression in a detrimental manner, as well. The data simply don't exist to show each nutrient's cellular effects. Moreover, methylating a single gene can have mu...Scientists demonstrate new method for discovering cancer gene function
...uestion has been whether what is found in the test tube is what really happens in human tumors. The patter...d cyclin D1 in human breast cancer cells in a test tube culture. They collected the genetic output of those cells, in the form of the RNA "messages" made by...Tipping the balance of prion infectivity
...ly, the researchers found this effect both in test tube mixtures of the prions and in the yeast cell cultures themselves. The findings emphasize the importance of looking beyond just the sequence of a prion protein in asking whether species barriers might be crossed. "Practically speaking, these findings...Laboratory 'theme park' re-creates RNA world for study
...e new, bigger RNAs are multiplied, returned to the tube and tested again for the same ability. Again, losers are removed, and winners multiplied. As this cycle repeats, slight mutations often appear in the RNAs, some of which create molecules superior to the parent molecule. Says Bartel, "Really, we end u...Exploring oil rigs and an ancient shoreline in the Gulf Of Mexico for new disease cures
...of animals such as sponges, sea urchins, sea fans, tube worms, soft corals and associated microbes collected. For instance, chemicals from each sample will be extracted and their ability to kill bacteria and fungi will be examined as an indicator of their therapeutic potential. The number and amount of c...Molecule found to be critical for kidney development
... are several structures, including a long, winding tube called the proximal tubule and octopus-shaped cells called podocytes that wrap their "feet" around blood vessels. After two days of treatment with the gamma-secretase inhibitor, neither podocytes nor proximal tubule cells formed. Another nephron stru...Platelet refrigeration method may ease shortages for transfusions, researchers report in Science
...on, Hoffmeister and her colleagues report. In test tube experiments with human platelets, the treatment also prevented much of the destruction that macrophages inflicted upon untreated, chilled platelets, according to Hoffmeister. The treatment consists of adding a sugar compound, called UDP galactose, wh...Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation
...ells, in effect recreating transcription in a test tube in a way that faithfully mimics the real process i...r has begun to apply what he has learned in a test tube to the study of living cells. For example, in a 2002 Nature report, Roeder and colleagues showed tha...