Tag: "tuberculosis" at biology news

USC study links historical increases in life span to lower childhood exposure to infection

...d rates of exposure to infectious diseases such as tuberculosis and malaria. The key to their theory lies in one word: inflammation. Infectious diseases cause chronic inflammation in the blood that, decades later, leads to heart attacks, strokes and cancers the classic killers of old age. "We've put pi...

'New and better drugs for tuberculosis' goal of UH professor

...iego, Calif. "Alanine racemase is a protein from tuberculosis that is a target for drug design," Krause said. "We are trying to make a small molecule that will specifically inhibit this enzyme. A molecule of this type would be a potential antibiotic to treat TB." Sponsored by the National Institutes of Heal...

Croatian skeletons reveal changing status of cancer in Europe across the centuries

...ould have been prone to diseases such as syphilis, tuberculosis and leprosy (and we found evidence for each of these conditions in individuals in the collection) and these illnesses (and others) would certainly have contributed significantly to mortality in our ancestors", added Dr. Slaus. "The change from these...

Bacteria spill their guts to aid researchers in quest for new antibiotics

...on the MscL protein from the bacterium that causes tuberculosis provided the model for what scientists believed was MscL's structure in its "closed" state. But UT Southwestern researchers led by Dr. Blount found that structure may actually have represented the nearly closed, rather than fully closed, state.Knowin...

U-M scientists use 21st-century technology to probe secrets of M. tuberculosis

...ne cells build to surround and contain invading M. tuberculosis bacteria. "Granulomas are the hallmark of tubercul...obiology's annual meeting held here this week. "M. tuberculosis has been living with people for at least 4,000 years," says Kirschner. "Because the bug has had all ...

Wisconsin chemists find a new chink in TB's armor

MADISON - The family of bacteria that causes tuberculosis (TB) and leprosy are notoriously sturdy. And altho...ork against tuberculosis." The bacteria that cause tuberculosis are literally tough as nails. With unique multilayered cell walls, the microbes resist easy treatmen...

Betty Ann Forbes wins 2004 ASM Founders Award

...ost recently on methods of detecting Mycobacterium tuberculosis and other pathogens. She is an award-winning teacher of medical students, residents, and postdoctoral-level microbiologists. Elected a Fellow of the American Academy of Microbiology in 1993, she has been a Diplomate of the American Board of Medical M...

Technique plucks rapidly evolving genes from a pathogen's genome

...w targets for researchers developing drugs against tuberculosis and malaria, and it could do the same for other in...already pinpointed previously unknown genes in the tuberculosis and malaria parasites that could be potential drug targets. "In the typical comparative method, res...

Scripps research scientist wins 2004 Koch Prize

...his discovery and subsequent investigations of the tuberculosis bacillus. In winning the Robert Koch Award, Beutler was acknowledged by the foundation for his "groundbreaking research on molecular mechanisms underlying recognition, signal transduction, and effector functions" of the immune system. He uses a ...

Germany starts clinical development of a new tuberculosis vaccine

...-clinical and clinical study program. "For our new tuberculosis vaccine candidates we are relying on genetically modified variants of the live BCG vaccine that has been in use since 1921," says MPI director, Prof. Dr. Stefan Kaufmann. "The vaccine consists of an attenuated bacteria that is very closely related to...

Aeras partners with Crucell to develop TB vaccine

...pre-clinical and clinical development of candidate tuberculosis (TB) vaccines. Aeras has agreed to provide Crucell...y is among the best in the world." Crucell's tuberculosis and malaria vaccine candidates are both based on the Company's PER.C6™ and AdVac™ techno...

Researchers identify the pattern of gene-expression changes for tuberculosis in a living host

...identified the genetic changes that Mycobacterium tuberculosis , the bacterium that causes tuberculosis, undergoe...on during the course of infection not only for M. tuberculosis , but for any pathogen. The findings will appear in an upcoming issue of the Proceedings of the Nati...

'Grey goo' misconceptions could harm poor in developing world

...onally used to mark cells; improved detection of tuberculosis with quantum dot optical biosensors. Development plans for a nanotech-based diagnostic kit to reduce the cost, time and the amount of blood required for TB tests was recently announced in India; inexpensive miniaturized medical diagnostic devices eas...

Gulf between rich, poor will grow if high-profile nanotechnology opponents prevail: ethics experts

...ally used to mark cells; Improved detection of tuberculosis with quantum dot optical biosensors. Development plans for a nanotech-based diagnostic kit to reduce the cost, time and the amount of blood required for TB tests was recently announced in India; Inexpensive miniaturized medical diagnostic devices e...

Third set of awards are announced under interagency biodiversity program

...armacological agents for AIDS, cancer, malaria and tuberculosis from tropical forest plants of Laos and Vietnam. Collaborating institutions include the National Center forNatural Sciences and Technology and Cuc-Phuong National Park in Vietnam, the Research Institute for Medicinal Plants in Laos, Purdue University...

Gene mutation leads to super-virulent strain of TB

...eley - Disabling a set of genes in a strain of the tuberculosis bacteria surprisingly led to a mutant form of the ... from the organs of mice infected with the mutated tuberculosis (TB) bacteria than for mice infected with the unmodified, or "wild-type," strain. By 27 weeks, the m...

Controversial UK badger killings analyzed by UC Davis expert

...versial practice of killing wild badgersto prevent tuberculosis in cattle apparently does no good -- and maymake m...hich kills badgers on and around farms wherebovine tuberculosis has occurred, did not prevent future TB outbreaksin those areas. In fact, there were 27 percent more...

Improving the body's 'homeland security' against TB

The microbe that causes tuberculosis operates the way a human terrorist would. With min...ey. "We will never break the chain of infection of tuberculosis the way we did with smallpox, for example. It's a different kind of bug." For this reason, McKinney ...

World Parks Congress focuses on wildlife health issues

...oth Canada and the United States. In South Africa, tuberculosis continues to be a management challenge in Kruger National Park. The primary goal for AHEAD organizers is establishing a multidisciplinary model involving both development agencies and environmental organizations that combines the traditionally separa...

UCLA study uses genetic profiling to distinguish types of leprosy

... may be more compromised. Researchers then used a tuberculosis bacteria sample to test whether LIR-7 activation would suppress the ability of the immune system to directly combat microbial pathogens. Researchers found that LIR-7 blocked the antimicrobial activity of another cell-surface receptor, called TLR or...

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