Tag: "tumor" at biology news
New Cancer Switch Discovered By Duke Medical Center Pharmacologists
...eliminate drug-resistance by selectively rendering tumor
cells vulnerable to normal cell death when treated with anti-cancer drugs. In the paper in Genes and Development, Pendergast and postdoctoral fellow Zonghan Dai reported a new way that both normal cell growth and cancer can be switched on in the cell...
Tumor Suppressor Gene Located In Liver Cancer Cells
...owth factor II receptor, or M6P/IGF2r -- acts as a tumor
suppressor gene in human liver tumors could help r... United States is only 4 percent. A report on this tumor
suppressor gene appears in the December issue of Nature Genetics. Along with principal investigator...
Second Breast Cancer Gene Located
... "Like BRCA1, the gene appears to function as a tumor
suppressor gene,"Futreal said. "In these families, the normal copy of the gene is knockedout, the mutated copy is retained, and the gene loses its ability to functionnormally." The process of mapping and cloning the gene was faster this tim...
Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
...ng too much of a potent inflammatoryprotein called tumor
necrosis factor alpha (TNFa). To test their idea, the researchers injected the TTP-deficient animalswith an antibody that neutralizes TNFa. In a dramatic and almost completereversal, all signs of disease completely disappeared. The findings suppor...
Rosemary May Have Anti-Cancer Properties
...s also found that rosemary's effectiveness against tumor
formationincreased with the amount of fat in the diet. "It suggests that people who eat high-fat diets will actually get themost benefit from rosemary," Milner says. "For typical Americans,who eat more fat than they should, rosemary may be particul...
Researchers Find Possible New Route to Making Cancer Cells Vulnerable
...otherapydrugs that would normally kill a cancerous tumor
and allowing runaway cellgrowth to continue. Physi... out to be better at overcoming drug resistance in tumor
cells,"Heitman said. "Simply jamming the pump mechanism may not be enough."...
Genetic Alterations Linked To Cancer In Some Blood Samples
...tients that were identical to alterations from the tumor
itself. Examining disease outcomes, the researchers found that 4 out of the 6 patients with positive test results subsequently died of their cancer compared to only 3 of 15 with negative test results. Additionally, the three patients who developed d...
Newly Discovered Gene Halts Cell Division and May Have Cancer Link
...omosomes -- an event that is notoriously linked to tumor
growth. The researchers suspect that certain gene...e study, the researchers identified a human breast tumor
cell line that is sensitive to the cancer drugs taxol and nocodazole. The drugs, called spindle inhi...
New Nonviral Gene Therapy System Could Help Fight Cancer
...r for scientists to getdisease-fighting genes into tumor
cells. Scientists have successfully used the...into these cells. But not allcancer cells within a tumor
divide at the same time. Current cancertherapies kill dividing cells, but dormant cells can divide a...
Team Identifies Switch For Tumor Suppressor Gene
...tified the protein that determineswhether or not a tumor
suppressor gene is able to do its job ofslowing do...one of thefirst known in a class of genes known as tumor
suppressors, whosejob it is to rein in cell growth. The work, by AssociateProfessor John Ludlow, gra...
Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
...system's ability tospecifically recognize and kill tumor
cells," says Dr.Federoff. The physicians used a herpes simplex virus -- the same onethat causes blisters and cold sores in people and animals, onlymodified so that it can't replicate -- to send into rats genesthat code for substances known as cy...
Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
... Drs. Federoff and Fong, is known as an autologous tumor
vaccine. "We're trying to exploit the immune system's ability to specifically recognize and kill tumor
cells," says Dr. Federoff. The physicians used a herpes simplex virus -- the same one that causes bl...
NIH Team Discovers Endocrine Tumor Gene
...n and malignant endocrine tumors. The MEN1 gene, a tumor
suppressor gene--a gene that inhibits abnormal cel...rigues researchers because it is unlike any of the tumor
suppressors currently known, according toAllen Spiegel, M.D., scientific director of the National In...
Emory Researchers Advance Gene Therapy Studies For Metastatic Melanoma Treatment
...he body's immune system to kill malignant melanoma tumor
cells, the most dangerous, and potentially deadly,...system to shift into overdrive and attack melanoma tumor
cells. Cytokines are natural proteins made by all cells, both normal and malignant. A single cell ...
Jefferson Scientists Discover Mechanism Of Viral Link To Disease Commonly Associated With Asbestos
...s team found that simian virus 40 (SV40), a DNA tumor
virus from monkeys, targets key proteins that n...e and grow out of control - possibly leading to tumor
formation and cancer. In the July 1996 issue of Clinical Cancer Research, Dr. Giordano's ...
Second Look Acquits Gene Of Role In Breast Cancer
... asks. "It'spossible. Wethink that a lot of what tumor
cells do involves activating normal, specializedcell behaviors in anabnormal way, and this abnormal RNA splicing may be one example of that."...
Second Gene Responsible For Tuberous Sclerosis Complex Identified
...called hamartin, named after hamartomas, a type of tumor
common to TSC andcomprised of multiple cell types.... the TSC1 and TSC2 genes are thoughtto function as tumor
suppressor genes and join more than a dozen other suchgenes that play an important role in the contr...
New Gene May Intensify Breast Cancer Growth
...ppears to be expressed atabnormally high levels in tumor
cells of most breast cancer patients, more thanhal...ce. In many cancers, but especially breast cancer, tumor
cells accumulate extracopies of genes that give the cancer a growth advantage. The new gene is onesu...
Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...key molecule linked to theimmortalization of human tumor
cells provides an important new target foranti-can...edat high levels in primary human tumors (11 of 11 tumor
samples studied,including 2 breast tumors and 4 ovarian tumors), but undetectable in most normalhuma...
Jefferson Scientists Find Potential Deadly Effects Of Two Missing Cancer-Suppressor Genes
... goes to the heart of how tumors develop and to tumor
genetics," he points out. "It was previously fo...s." When one cancer-protecting--so-called tumor
suppressor--gene is missing, mice--and people--are much more likely than normal to develop can...
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