Three genetic steps convert normal mammary cells into breast cancer cells
...ntification of the minimal genetic requirements of tumorigenesis will help to understand the mechanisms underlying the uncontrolled and destructive growth behavior of cancer. The genes chosen for use in this experiment SV40 large-T, telomerase hTERT and oncogenic H-rasV12 interfere with essential regulatory path...Understanding tuberous sclerosis
...of biological events linking TSC gene mutation and tumorigenesis has remained unclear. As published in Genes & Development, Dr. Duojia Pan and Dr. Xinsheng Gao have determined that TSC1 and TSC2 proteins form complexes in cells, and negatively regulate the insulin pathway in Drosophila. In Drosophila the insulin ......al tumor suppressor genes, like Dmp1, that promote tumorigenesis lends insight into the genetic culprits that may be responsible for tumor development when the list of usual suspects fails....Other highlights in the March 20 issue of JNCI
...nescence, and these mutations may favor melanocyte tumorigenesis by impairing senescence, cell differentiation, and...ations in the INK4A-ARF locus may favor melanocyte tumorigenesis by impairing cell senescence and differentiation. They report their results in the March 20 issue of......nificant difference in the pathway of Ras-mediated tumorigenesis in mice and humans. The Ras gene plays an important role in human tumorigenesis. Ras is a proto-oncogene: It encodes a protein (Ras) which normally regulates cell growth, but certain oncogenic mutations in the Ras gene can result in the production of...Unraveling the genetics behind melanoma and colon cancer
...atenin, the role of g-catenin in Wnt signaling and tumorigenesis is less well established. To uncover novel genes that are activated in response to b- and g-catenin expression, Dr. Ben-Ze'ev and colleagues preformed a DNA microarray analysis of human renal carcinoma cells expressing b-catenin and/or g-catenin. Of ...Scientists discover role for c-myc gene in tumor angiogenesis
...er delineation of role of c-Myc in promoting human tumorigenesis is needed, but as it stands, this study presents strong evidence to suggest that the disruption of c-Myc may prove successful as an anti-angiogenic tool in cancer therapy....Scientists discover role for Cdk4 in making cells cancer resistant
...activated, demonstrating that Cdk4 is required for tumorigenesis even when commonly mutated tumor suppressor genes are non-functional. This discovery that diminished Cdk4 expression steers cells into a protective state of senescence against oncogenes like Ras has significant therapeutic implications. In light of ...JCI Table of Contents, March 14, 2003
...0% of the samples) appears to be an early event in tumorigenesis andcan be detected in sputum samples. Thus it might serve as a potentialdiagnostic marker. CONTACT: Yi-Ching Wang National Taiwan Normal University Department of Biology No. 88, Sec. 4 Tingchou Road Taipei 116, TAIWAN Phone 1-8862-2933-6876 Fax 1-...JCI table of contents, 2 June, 2003
...ases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis AUTHOR CONTACT: Abdel-Majid Khatib Ottawa Health Research Institute, Ottawa, Ontario, Canada. Phone: (613) 798-5555 ext. 16086 Fax: (613) 761-4355 E-mail: mkhatib@ohri.ca View the PDF of this article at: https://www.the-jci.org/press/17220.pdf ...Finished Y-chromosome sequence reveals a genomic 'crystal palace'
...adal sex determination, skeletal growth, germ-cell tumorigenesis and graft rejection, he said. "We know that there are many diseases for which men or women are at higher risk," said Page. "It has been conventionally assumed that these differences in disease susceptibility reflect the action of sex hormones, and no...Scientists identify genetic link between cancer and aging
... recognized deep links between cell senescence and tumorigenesis for some time. It's gratifying to see another of these links identified that is conceptually interesting and may have practical importance."...JCI Table of Contents, 15 August 2003
...PANING COMMENTARY:Decrypting the role of Cripto in tumorigenesis AUTHOR CONTACT: Michael M. Shen Center for Advanc...nd the pathogenesis of developmental disorders and tumorigenesis of the central nervous system due to dysregulated Shh signaling mediated by IFN-gamma. TITLE: Dysre...JCI table of contents, December 15 2003
...wth and tumor suppression. TITLE: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene AUTHOR CONTACT: Beth Levine Columbia University College of Physicians and Surgeons, New York, New York, USA. Phone: 212-305-7312 Fax: 212-305-7290 E-mail: levine@cancercenter.co...Cross-species comparison reveals shared features between tumorigenesis and organogenesis
... as Lobstein and Cohnheim in the 19th century that tumorigenesis recapitulates aspects of development," Rowitch sai...rk within which gene expression in development and tumorigenesis can be studied. By this means, the role of a particular gene in tumor progression can be better unde......ansfected cells in vitro and in rodent models of tumorigenesis and angiogenesis. The DNAzyme-transfected endothelial cells expressed less c-Jun protein than mock-transfected cells. Transfection with the DNAzyme blocked endothelial cell proliferation and migration in vitro , inhibited angiogenesis in rat corneas...