New Cancer Switch Discovered By Duke Medical Center Pharmacologists
...e is now being distributed by SUGEN for testing on tumors taken from humans, he said. In the October Molecular and Cellular Biology paper, Cortez, Pendergast and graduate student Lisa Kadlec also reported the results of producing slightly altered, or mutated, versions of the BCR-ABL gene. Their aim was to b...Tumor Suppressor Gene Located In Liver Cancer Cells
... -- acts as a tumor suppressor gene in human liver tumors could help researchers develop an early diagnostic...n or having a handle on how one could detect these tumors when they're much smaller could have a significant impact on survival," he said. The protein recepto......struction mechanism is disrupted, though,cancerous tumors made up of rapidly reproducing cells can result....Genetic Alterations Linked To Cancer In Some Blood Samples
...lood appears to be associated with large, advanced tumors and with cancer that has spread," says lead author David Sidransky, M.D., associate professor of otolaryngology/head and neck surgery, and oncology. Sidransky cautions that the test does not appear useful as a screening test for cancer. "But it mig...Newly Discovered Gene Halts Cell Division and May Have Cancer Link
...genetically unstable breast, ovarian, and prostate tumors may have defects in the gene, known as MAD2. The n...gs may be especially effective in the treatment of tumors with a defective checkpoint, Dr. Benezra says. That's because the drugs, coupled with the faulty che...Selenium Supplements Can Reduce Cancer Rates
...ls fed diets high in selenium had 50 percent fewer tumors than those fed diets of average selenium content. Combs is not recommending the use of oral supplements of selenium; however, he does emphasize the importance of consuming low-fat diets that are adequate in selenium and are balanced with respect to o...New Study Shows Steps Leading To Colon Cancer
... or it prevents them from dying, leading to benign tumors that can later become malignant. "It is now clear that this sort of mistake underlies essentially all cases of colon cancer and many melanomas, a form of skin cancer difficult to treat," he said. A report on the findings, supported by the Nationa...Prostate Cancer's Aggressiveness May Be Predicted Early By The Ratio Of Free To Total PSA
...ishing which cancers are serious, life-threatening tumors and which ones are not. The ratio of free to total PSA in sera may give physicians this information." Today, physicians have effective means of diagnosing prostate cancer, but there is great debate about which treatment is best for a cancer diagnose...Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
... to completely eliminate theformation of cancerous tumors in animals or humans. Lead author of the report is Yuman Fong, M.D., one of theworld's leading liver cancer surgeons, at Memorial Sloan-Kettering Cancer Center in New York City. Other authors includeHoward Federoff, M.D./Ph.D., chief of the Univ...Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
...to completely eliminate the formation of cancerous tumors in animals or humans. Lead author of the report is... very effective combination, completely preventing tumors from forming in 8 of 11 rats. IL-2 stimulates the formation of lymphocytes known as cytotoxic T cell...Purdue Researchers Prod Plants To Clean Up Pollution
...r. In humans, radioactive strontium can cause bone tumors and, possibly, leukemia. Webb hadn't set out to clean up radioactive waste. Her work started with calcium, but led to strontium. She was, and still is, fascinated by the way certain plants take up and store calcium. Plants need a large amount of calc...NIH Team Discovers Endocrine Tumor Gene
...s identified a gene that can cause multiple benign tumors of the parathyroid and pituitary glands, as well as islet cell tumors leading to pancreatic cancer. Their discovery of the gene for multiple endocrine neoplasia, type 1 ...Emory Researchers Advance Gene Therapy Studies For Metastatic Melanoma Treatment
...es of this ingredient can be delivered to melanoma tumors directly, the researchers believe it might be used... they shrank by at least 90 percent, compared with tumors not treated with the GM-CSF gene. "Our next step is to mimic the human condition even more closel...Jefferson Scientists Discover Mechanism Of Viral Link To Disease Commonly Associated With Asbestos
...eys, targets key proteins that normally prevent tumors from forming, rendering them ineffective. These proteins, made by so-called tumor-suppressor genes, are in the retinoblastoma family ( pRb , pRb2/p130 , and p107 ). A viral protein called SV40 T-ag (T-antigen) binds to and inactivates t...Second Gene Responsible For Tuberous Sclerosis Complex Identified
...umber of abnormalities, including seizures, benign tumors in several organs,and variable emotional and cogni...most commonsymptom. Other common features include tumors of the brain, kidneys, eyes, andother organs and a salmon-colored, seed-like rash on the face. Thes...New Gene May Intensify Breast Cancer Growth
... they have a different clinical outcome, are their tumors different,do they develop at a different age or at a different rate" We don't have answersto any of those questions yet, but we are actively seeking the answers," saidTrent. "A lot is known about how steroid receptors work, but the wiring of how they...Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...e gene is expressedat high levels in primary human tumors (11 of 11 tumor samples studied,including 2 breast tumors and 4 ovarian tumors), but undetectable in most normalhuman tissues, including breast, ovary, heart,...Jefferson Scientists Find Potential Deadly Effects Of Two Missing Cancer-Suppressor Genes
... "The observation goes to the heart of how tumors develop and to tumor genetics," he points out. "It was previously found that this particular combination of altered genes is significantly lower in human tumors--our results may suggest why that is the case. These are two of the most comm...Peutz-Jeghers Disease Gene Identified: Enzyme Loss Causes Polyps And Cancer
...threatening feature of this disease are various tumors which can develop in the gastrointestinal tract, pancreas, ovaries, testis, breast and uterus. The growth of benign hamartomatous tissue appears to be the basis for the later development of malignant neoplasms. Peutz-Jeghers syndrom......called walleye dermal sarcoma virus (WDSV) and the tumors it causes on the skin of fish. Because certain fish tumors grow and regress on a seasonal basis, the Cornell researchers are interested in WDSV in walleyes and...