Tag: "tumour" at biology news

Breast cancer follow-ups 'no longer guess-work' thanks to new physics research

...significantly reducing our ability to detect local tumour reccurrance. This means that six years worth of a physician's time and outpatient clinic costs could instead be diverted to parts of the treatment process where it would do more good." Using data taken from a series of patients with T1 and T2 stage (...

Researchers model embryo implantation and tumour metastasis in fruit flies

...inked to mammalian embryo implantation, as well as tumour metastasis, plays similar roles in fruit fly devel... apart and die. This has an exciting connection to tumour cell metastasis in humans. "When a tumour metastasizes, cells in fact have to decide to leave it and...

Astrazeneca announces EU marketing approval for Faslodex(TM)

... well-tolerated treatment option. However, in time tumour cells can grow resistant to treatment with these hormonal therapies and as a result there is a need for new agents to which tumours are not resistant. 'Faslodex' is an exciting new type of therapy, which brings new choices for women with advanced dis...

Preoperative treatment with Arimidex(TM) allows patients to undergo less extensive surgery

...le) results in clinically beneficial reductions in tumour volume, extending the range of surgical options, which can allow patients to undergo less extensive surgery. This latest evidence adds to the already extensive clinical data set for anastrozole - the largest available for any aromatase inhibitor. An...

New diagnostic tool brings effective treatment closer to patients

... Dr. Koki. Looking at the 'genetic signature' of a tumour can provide crucial information to contribute to the choice of first-line treatment. It can also avoid over-treatment or prolonged treatment with ineffective drugs and the associated side effects. The use of microarrays will be able to predict rel...

Scientists discover that metastases share a similar genetic profile to their primary tumour

...ose the best treatment for that particular type of tumour (from specific types of chemo-, radio- or hormonal...uvant) treatment could not only shrink the primary tumour but might also prevent the outgrowth of micrometastases, thereby saving lives, as metastases that oc...

First large-scale trial of genetically personalised treatment for breast cancer to start soon

...e independent trial to study the role of molecular tumour signatures in breast cancer will get underway in the coming year, scientists announced today (Friday March 19) at the 4th European Breast Cancer Conference. TRANS-BIG, a translational research network involving about 40 partners from all over Euro...

Survey reports fall in stem cell transplants for breast cancer

...ses and highlighting the power of the graft versus tumour effect. This shift was now being seen in solid tumour treatment with small studies testing whether inducing graft versus host effect in solid chemotherapy...

Scientists identify cells that lead to retinoblastoma

...y's natural protective barriers that guard against tumour growth," explains Dr. Rod Bremner, the study's lea...y begin dividing uncontrollably, as happens when a tumour begins growing. Normally, a gene called Rb prevents retinoblastoma by blocking cell division. In chi...

Tumour suppression

...ged during normal metabolic processes is linked to tumour suppression, says a new University of Toronto stud...s81 mutation. If the mutation can be tied to human tumour formation, it should allow people who test positive for such a gene mutation to monitor their health...

European Commission approves Herceptin + Taxotere as 1st-line therapy in HER2-positive breast cancer

...eptor 2) protein are present on the surface of the tumour cells. This is known as 'HER2 overexpression'. High levels of HER2 overexpression are present in a particularly aggressive form of the disease which responds poorly to chemotherapy. Research shows that HER2 overexpression affects approximately 20-30%...

New compound 'highly efficacious' at reducing human tumour growth

...locks VEGF-induced vascular permeability, inhibits tumour angiogenesis and induces apoptosis in human tumour models said Dr. Gerhard Siemeister of Schering AG, Corporate Research, Berlin speaking at the 18th m...

Chemoradioimmunotherapy for advanced breast cancer: hope for the future?

...ells are less responsive to treatment than primary tumour cells. This is partly caused by the fact that the ...ncogenes are expressed more strongly in metastatic tumour cells), which means that the cells fail to die following treatment with chemotherapy drugs and radia...

Final Alert: 16th EORTC NCI AACR Symposium

...anti-angiogenesis researchers find way to exploit tumour blood vessels New cell death-inducing monoclonal antibody results from early study targeting TRAIL R2 protein Lypcopene and vitamin E inhibits prostate tumours new laboratory results underpin epidemiological evidence patient trial now started I...

16th EORTC NCI AACR Symposium 'Molecular Targets and Cancer Therapeutics'

...evolutionary approach to angiogenesis - exploiting tumour blood vessels to boost chemotherapy and radiotherapy instead of (or before) killing them. Successful mouse study leads to patient trial. * Professor Eric Van Cutsem: International trial results shows way to measure success of centuximab (Erbitux). Ra...

Trial shows which brain cancer patients benefit from temozolomide

...l, if any, benefit. The genetic predictive test on tumour biopsies to identify who will benefit from the dru...s in the DNA. Dr. Hegi, head of the laboratory of tumour biology and genetics at the Department of Neurosurgery, University Hospital of Lausanne, Switzerland...

Award winning researchers reveal potential new role for Glivec

...ermatofibrosarcoma protuberans (DFSP) a malignant tumour that occurs in the second layer of the skin (the d...firmed through resections of the regions where the tumour was present and two achieved complete response confirmed by tumour assessment. Four had partial resp...

Phase II trials of second-generation antisense cancer drug planned following successful early study

...could identify the biologically active dose in the tumour tissue. Being able to identify the active dose in this way gives us confidence that the Phase II dose of the drug that we have selected is the appropriate one. The Phase II studies are of a more conventional design, looking at response rates from OGX...

Belgian researchers explore revolutionary approach to angiogenesis

...russels have turned the whole concept of targeting tumour blood vessels on its head. Instead of the conventional approach of trying to starve tumour cells of the blood supply they need to grow, they are doing the opposite opening up the tumour bloo...

International study findings link acne-like rash to effectiveness of new targeted cancer treatment

...f research. "We saw independently reviewed partial tumour responses in 12% of patients and a median survival... 46 patients who did not develop a rash none had a tumour response and their median survival was only 2.1 months. Of the 142 with a grade one rash 8% had a tu...

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