Tag: "turning" at biology news

Gene more than doubles risk of depression following life stresses

...dimmer switch, controlling the level of the gene's turning on and off. This normal genetic variation, or polymorphism, leads to transporters that function somewhat differently. The short variant makes less protein, resulting in increased levels of serotonin in the synapse and prolonged binding of the neurotr...

Protein holds promise as new diabetes drug target

...r for Research and a co-author of the report. "By turning on glucokinase, this novel compound improves insulin secretion by the pancreas and stimulates glucose usage by the liver, both of which are abnormal in diabetes."Magnuson cautions that it's too early to tell what the real value of a glucokinase-activ...

Scientists find gene that protects against potato blight

...f fungal pathogens that wreaks havoc in the field, turning tubers to mush and invariably killing any plant it infects. "We think this could be very useful," says John Helgeson, a UW-Madison professor of plant pathology, a research scientist with the U.S. Department of Agriculture and a senior author of the ...

Abnormal plant shows scientists path to plant, animal development

...gous, or corresponding, to PKL is also involved in turning off developmentally regulated genes. So, we're finding similar regulatory roles for both human and plant proteins." Ogas and his team found the embryo-promoting genes by studying a strain of Arabidopsis in which PKL is abnormal, or mutated. The mutat...

Purdue genetic discovery may aid plants and human medicine

...t growth by changing the gene slightly rather than turning it off altogether. They know that one MDR mutation in another plant species results in plants that are shorter and stockier with a bigger root system than in the wild type. These mutants are more resistant to wind and may be more robust in difficult ...

'Reverse CPR' performed on back could better restore blood flow

...s performed with blood pressure monitoring. Then, turning the patients over and adding reverse CPR for 15 minutes, doctors were able to increase average systolic blood pressure (the upper number in blood pressure measures) from 48 mmHg to 72 mmHg. The new approach also improved average arterial blood flow ...

ENBREL rapidly, significantly improved back pain, mobility, function in ankylosing spondylitis

... put on socks or look over their shoulders without turning their bodies." Adverse events were similar to those reported in previous clinical trials of ENBREL, with injection site reactions occurring more frequently than in the placebo group. The most frequent adverse events in placebo-controlled RA clinical ...

Key regulatory enzyme is a molecular 'octopus'

...emarkably effective and multitasking mechanism for turning off G protein signaling." Thus, he said, the GRK2 is built to bind to the receptor and phosphorylate it, allowing attachment by beta arrestin, and at the same time, bind the G protein to switch it off. "This structural determination has significance ...

Is there an unexpected price for late night high tech excitement?

...udy suggests that there is an unexpected price for turning on the computer late at night for high tech excitement. The old standby of a cup of warm milk before bed may be the best advice, after all....

'Immortalized' cells enable researchers to grow human arteries

... the areas of cancer and bioengineering are slowly turning their attention to potential new avenues to exploit the properties of telomeres. "Telomeres are present in all normal dividing cells and act as a built-in check against unwanted cellular proliferation," Counter explained. "In this case, telomere shor...

Body clocks keep migrating monarchs on course, Science study shows

...es of biology." Research in other animals has been turning up a number of genes that make up the circadian clock, as their expression oscillates in a daily cycle. The clock is "entrained" to the daily light cycle via specialized by special light-sensitive cells, called photoreceptors. The researchers found t...

Making sense of the genome

...hear of a new genome sequence being completed, yet turning sequence information into knowledge about what individual genes do is very difficult. An article published in Journal of Biology this week will simplify this task, as it describes a new online tool that dramatically improves predictions of how indiv...

Many pregnant women may have depression, but few getting treatment, study finds

...'honeymoon' away from depression risk, but this is turning out to be a myth," says lead author Sheila Marcus, M.D., a clinical assistant professor of psychiatry at the U-M Medical School. "We now know that the hormones and brain chemistry involved in depression are known to be affected by changes in other ho...

Mutated protein combination tied to excessive sugar production

...produced in the pancreas, has the opposite effect, turning off gluconeogenesis when normal feeding resumes. Insulin activates the insulin receptors on liver cells surfaces, which send signals into the cells nuclei where they are received by the switch made up of the PGC-1alpha and FOXO1 proteins. FOXO1 prote...

Critical early-defense trigger in plants found

...le to regulate the production of this signal. The turning up of this signal should lead to the turning on of a large portion of the defense arsenal. The end result could be crop plants that can better wa...

Researchers find viral protein that mimics its way into cells

... Calcium plays a major role in cellular processes, turning on genes that drive cellular division, among other roles. But it also has to be regulated very tightly within the cell, Lairmore said. Too much calcium and the cell dies. ...

Tourism leaders and conservation organizations to devise Caribbean conservation action plan

...g the importance of reducing biodiversity loss and turning conservation into a source of competitive advantage....

Novel method identifies 'hidden' genes

... rise to an adult plant or animal require a lot of turning on and off of genes." For many years, miRNAs went undetected because they do not code for proteins--the benchmark traditionally used to define genes within a genome. Interest in RNA as a gene regulator began when researchers first discovered two sma...

New DNA chip rapidly detects, identifies dangerous pathogens

...ht DNA sequence, however, the flowers stand erect, turning the entire field--and thus the chip--from green to bright yellow. The unfolding of the chip's detector DNA strands happens when new DNA with a precise sequence is dripped onto the chip. The chip's DNA is designed to prefer to be bonded with a specifi...

Discovery of how prolactin travels to gene's machinery helps explain its role in breast cancer

...d into the DNA. CYPB also is an active partner in turning on the genes critical in the development of cancer. This is exciting news, says Dr. Clevenger. It means we can target drugs to particular tissues in ways not possible before. His own laboratory has applied mutant forms of the CYPB protein to breas...

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