Molecular motor implicated in tissue remodeling
...known enzyme present in the skin and other tissues turns out to be a molecule-sized motor that extracts its fuel from the road it runs on, according to researchers at Washington University School of Medicine in St. Louis. Their discovery appears in the Oct. 1 issue of Science. The enzyme, MMP-1, is a membe...UT Southwestern biochemist honored with NIH Director's Pioneer Award
...itutes of Health." One of the most significant turns Dr. McKnight took in his career was to move from his early work on transcription factors to the study of gene regulation in the brain. One of his current projects has led to the discovery of genes that control the body's internal clock and regulate s...Grant advances biochemical engineering laboratory
...hemical engineering takes what farmers produce and turns it into other useful products that have more value than the crops themselves. It gives farmers one more way to market what they grow." Tech's biochemical engineering initiative also has received major equipment support from Cargill, as well as schol...Experimental drug shown to block mutant protein causing blood disease
...te blood cells in MPD damages organs and generally turns into an acute leukemia that can be fatal. The report appears in this week's Online Early Edition of the Proceedings of the National Academy of Sciences . Jing Chen, PhD, of Brigham and Women's, and Daniel J. DeAngelo, MD, PhD, of Dana-Farber, are th...UAF scientists discover new marine habitat in Alaska
...o a marine journal. And if one of their rhodoliths turns out to be a new species, they'll have the honor of naming it. ...Green, leafy spinach may soon power cellphones and laptops
... like the main ingredient in soaps and detergents, turns out to be ideal for keeping protein complexes functional on a cold, hard surface. The spinach-sandwich device has no water, and proteins usually need water to survive, but using Zhang's detergent peptide, the researchers were able to stabil...Research suggests new avenue for stopping, preventing colon cancer
... high-fat diet without gaining weight. A drug that turns on PPARdelta is being tested in patients with fat metabolism disorders. However, when the drug was given to a strain of mice with a genetic mutation that makes them susceptible to developing pre-cancerous intestinal polyps, both the number and size ...JCI table of contents September 15, 2004
...l transduction pathways. In response to LPS, a TLR turns on the serine/threonine kinase Cot/Tpl2, which then activates ERK1/2 in macrophages. It remains unknown whether Cot/Tpl2 is involved in responses to other bacterial components or in the activa-tion of other immune cell types. Tetsuya Matsuguchi and c...Human chromosome 5 final sequence analysis released to public
... much more or less severe forms of the disease. It turns out that the region contains many duplications and other rearrangements and varies considerably between people. Schmutz said that, with the sequence for this region in hand, researchers can now study how variations in the number of deletions or repet...Protein is key to fatal disorder and normal cell function
... forth between the Golgi and the cell surface. "It turns out that the cln3 protein may be a crucial protein involved in the transport of vital lipids from the Golgi, where they are made, to where they are needed -- for example, at the cell surface," Boustany said. One of those vital lipids is galactosylcer...Sugar-coated sea urchin eggs could have sweet implications for human fertility
...ions of the ocean were kept from interbreeding. It turns out they were only seeing part of the picture. New research from the University of Washington's Friday Harbor Laboratories shows that common assumptions about sea urchin reproduction don't hold true for all species of the invertebrate creature. The ...UCLA molecular biologists uproot the tree of life
...nd multicellular animals on the higher branches -- turns out to be a misnomer, UCLA molecular biologists report in the Sept. 9 issue of the journal Nature . "It's not a tree; it's actually a ring of life," said James A. Lake, UCLA professsor of molecular biology. "A ring explains the data far better." Lak...Small, Smac-like molecule encourages death of cancer cells
...activity as it proceeds." Dr. Wang said, "If this turns out to be true, it's remarkable, because then you would only need a tiny amount to have a dramatic impact." The next step in the research is to test the compound in animals. "If it does well, hopefully it will someday find its way to people," he said...Tiny molecules have big potential as cancer drugs, Stanford researcher believes
...cules at his presentation. If one of the molecules turns out to vanquish tumors but not their hosts, it could become one of the first drugs of its kind, he said. "Most cancer drugs are very toxic," he said. "There are very few rationally designed oncology drugs in use today that are made with a specific ta...Marathoning mice could have Olympian effects on obesity
...late fat metabolism appears to prevent obesity and turns laboratory mice into marathon runners, a Salk Institute study has found. The discovery of the switch could lead to treatments for obesity and disorders associated with it, such as heart disease and type 2 diabetes. The study, led by professor Ronal...Regular physical activity really does boost immune system in older men
... the lines of, "I feel like a 25-year-old." As it turns out, judging by the reaction strength of their immune system to an unknown, but harmless, protein antigen, it's possible for men over 70 to mount an immune response similar to that produced by much younger men -- if they get regular moderate physical...Engineering endurance: The future of the Olympics?
...l, the normal mice prevailed. Downhill running, it turns out, favors glycolytic metabolism; uphill running and swimming favor oxidative pathways, which the mutants were predisposed toward. But their inappropriate use of this pathway came at a cost. By the final day of a four-day exercise routine, the mutan......eedback loops, in which the expression of one gene turns on the expression of a second gene, which turns off the first gene, which turns off the second gene, which turns the first gene back on, etc., day i...British scientists exclude 'maverick' colleagues, says report
...such scientifically and politically charged issues turns on the way scientists present themselves to the outside world. "The image of a scientific establishment attacking and punishing individual researchers with contentious results — such as the MMR vaccine controversy - has done little to inspire pu...Early clinical treatment can halt progression of Alzheimer's disease, UCI researchers find
...es through various stages," LaFerla explained. "It turns out that the clearance of the tangles is critically dependent on their chemical state, that is, their 'phosphorylation state,' phosphorylation being the addition of phosphate groups to particular amino acids in a protein. Once the tangles become hype...