Tag: "turns" at biology news

'Smart gene therapy' protects against damage from heart attack

...attack. As soon as the oxygen declines, the sensor turns on the therapeutic gene, thereby protecting the heart. In addition to its potential for patients with heart disease, the strategy might also prove useful for any condition in which tissues are susceptible to loss of blood supply, including stroke, sh...

LICR/UCSD team solves mystery of centromeres

...Medicine to determine how a protein called CENP-A, turns the normally flexible center section of a rod-shap...ly synthesized chromosome. The presence of CENP-A turns the centromere into a staff DNA and protein complex, and ensures that the centromere is maintained e...

Insecticide resistance: A constraint on evolutionary change

...the 119 position. But it means - critically, as it turns out - that a single mutation of the site cannot result in the G119S change needed for resistance. In A. gambiae , it only takes one base mutation to alter the code in the right way; in Ae. aegypti , it takes two adjacent base mutations - a far less...

NSF awards $10 million in grants to ocean sites for long-term ecological research

...h Pacific Ocean. As water from the westward drift turns south and becomes the California Current, it brings with it cool, fresh water from the sub-arctic region. The California Current System off central and southern California consists of the broad, southward-flowing California Current; a persistent but...

How wounds heal Clues from flies

...n't pick that scab, you'll just make it worse!" It turns out, Mom was on to something, according to research published on-line in the open-access journal PLoS Biology. Tissue damage in humans triggers a well-characterized response marked by rapid blood clotting and a recruitment of epidermal cells to the i...

Carnegie Mellon neuroscientist develops tool to image brain function at the cellular level

...uorescent protein (GFP) with the gene c-fos, which turns on when nerve cells are activated. Using this method, researchers can see specific neurons glow as they are activated by external stimuli such as sensory experience or drug treatment. "Our transgenic mouse is a novel tool that can be used to visualiz...

Oxygen sensing in worms may hold key to healthy blood pressure in humans

...he border of a Petri dish. "Bordering and clumping turns out to be a laboratory artifact," says Marletta. "The bacteria that the worms feed on concentrate at those borders. Since the bacteria are also consuming oxygen, the concentration of bacteria and the swarm of worms combine to lower the oxygen concent...

Researchers discover how worms' noses sense oxygen

...n, in particular the exact binding site for NO. It turns out to be a heme molecule nearly identical to the heme that binds oxygen in hemoglobin to carry it through the blood stream to muscle. The heme in hemoglobin cannot discriminate between oxygen, carbon monoxide (CO) or NO, which is why CO is toxic: it...

Protein controls acid in cells by direct detection of volume changes, study finds

...ws that as cell volume increases, this transporter turns off. If volume decreases, it turns on by directly sensing mechanical changes in the membrane," continued Dr. Hilgemann. The NHE1 transp...

Cancer gene MYC emerging as key research target

... believed that when MYC binds to a target gene, it turns that gene on, or activates it. Surprisingly, new w...ies looked at which genes are bound by MYC, and it turns out to be a great percentage of genes--one out of every six," McMahon says. "Our work has extended w...

Innovative efforts target epigenetics, molecular imaging

...k interact with the transcriptional machinery that turns genes on or off, thereby spurring or preventing the production of the proteins that those genes encode. Also, for certain genes, the addition of methyl groups serves to distinguish between the gene copy inherited from the father and the one inherited...

Stem cells commit to a future of fat with one signal

... for bone morphogenic protein 4, is a protein that turns on or off genes involved in cell function and growth. Identifying which genes are affected by BMP4 is likely to hold more clues to how stem cells commit to a more specific cell fate, say the researchers. "With our new experimental system, we ...

New technique images gene expression in mice

...tic medicine seemed right around the corner. As it turns out, identifying genetic flaws has proved easier than getting corrected genes to work in the cells that need them. Researchers at the Departments of Nuclear Medicine (Radiology) and Pediatrics at Case Western Reserve University may be able to help. T...

How genes get us wired

... muscle as both develop together. Because Hoxb1 turns other genes on and off, it may guide developing nerves to facial muscles by acting on genes such as Ephs and Ephrins, which already were known to emit chemical signals that help guide nerves to the tissues they control, says Arenkiel. "Ben has sho...

Volcanic soils yield new clues about the emergence of powerful chiefdoms in Hawaii

... system to well below it," Vitousek explained. "It turns out that, within the boundaries of the system, phosphorus levels are high, but above and below the system, the levels are low." The researchers also measured the concentration of several chemical bases in the soil calcium, magnesium, sodium and pota...

All ecosystems are equally productive under drought conditions

...?" Although it seems a simple question, it turns out to be a toughie, he said. "My wife can answer it for her garden, but you can't take the information that my wife knows for her garden and apply it to many different biomes around the world." In the early 1970s, ecologists tried to answe...

Need sex? It's probably something about stress

Heat turns colonial algae into hotties. When algae find the...arch. "This is the first demonstration that stress turns on sex-inducer genes." The research will be published in the June 9 issue of the Proceedings...

Choice of food helps hungry caterpillar

...and Chinese lantern. H. subflexa's choice of food turns out to have unusual benefits in the three-way struggle between herbivores, their predatory wasps and the plants. "We know that many plants produce volatile chemicals when chewed on by herbivores and that some of these chemicals attract...

Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy

...a regulatory or suppressor cell, which essentially turns off the attackers. Basically, it's a numbers game, and the problem in the onset of this disease is that there are not enough of the regulatory cells that suppress the immune response against the body's insuling-producing pancreatic islet cells," says...

Researchers establish first molecular link between eating and aging

...hen the Sirt1 protein senses short-term famine and turns off the receptors that normally keep fat stored in fat cells. Thus fat cells shed their fat. They write that this happens because the "Sirt1 protein activates a critical component of calorie restriction in mammals; that is, fat mobilization in white...

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