Tag: "uncontrolled" at biology news

New Cancer Switch Discovered By Duke Medical Center Pharmacologists

...ncer gene, or oncogene, called ras, which launches uncontrolled growth. In the Proceedings paper, Gishizky, Cortez and Pendergast reported discovering that a purposely "damaged" form of GRB-2 could suppress activation of ras and reverse the cancerous growth of human leukemia cells in test tubes. "These results su...

Scientists Discover How Genes Work Together To Control Neural Development

...or occurssomewhere along the pathway, resulting in uncontrolled cell division ratherthan controlled cell differentiation." Last year Lai discovered an important clue about how a component ofthe signal-transduction pathway--a special kind of cell-growth regulatorknown as a neural inhibitor--works genetically. He...

Rapid Progress Reported On New Class Of Anti-Cancer Drugs

...sin the Ras biochemical pathway that result in the uncontrolled growth ofcancers. These cancers include up to 90 percent of pancreatic cancers, half ofall colon cancers and a quarter of all lung cancers. The reports by university and pharmaceutical company researchers onprogress in both understanding and...

Tinkertoy Robot Shows How Humans Walk

... "It does, however, highlight the possibility that uncontrolled dynamics may not just contribute to fore and aft balance in walking but also to side-to-side balance," said Ruina, an associate professor of theoretical and applied mechanics, who is also interested in the energetics of rowing, biking, walking, brach...

Retinoic Acid Used In Cancer Treatment

...versity researchers studying leukemia to block the uncontrolled cell division that leads to cancer. The chemical is retinoic acid, a product of vitamin A, which the body manufactures from carotenes, the compounds found in a wide assortment of yellow-orange vegetables and fruits, from carrots and sweet pot...

CAK Activation Of Plant Cell Cycle: Scientists Find Another Piece In The Jigsaw Puzzle To Help Explain Why Plants Do Not Develop Cancer Spontaneously

...strong preventive mechanisms to avoid this kind of uncontrolled cell division. On the other hand, and unlike animal cells, plant cells that fulfill specific functions and are therefore differentiated are able to reactivate cell division. This is the reason why it is possible...

New Airway's 'Smarts' Ensure That Patients Get Plenty Of Oxygen

...en it'sdone by paramedics in the field -- a noisy, uncontrolled settingwhere intubation may be greatly complicated by patients who arebloody or vomiting, or who have trauma to the face or throat.There's also sufficient jostling en route to the hospital todislodge even the sturdiest airway." Emergency care pr...

Molecular Marker May Identify Bladder Cancer Patients Most Likely To Recur

...oint disappears, allowing the cell to divide in an uncontrolled fashion. Earlier work has shown that bladder cancer patients with alterations in the p53tumor suppressor gene are more likely to recur or progress to metastaticdisease. In addition, p53 is known to be a primary regulator of p21, sincegenetic changes...

Frequent Genetic Mutations In Hepatocellular Carcinoma

...ly accumulatesinside cells. This build-up leads to uncontrolled cell proliferation, thecharacteristic process underlying cancer. INSERM research group 129 have nowfound that these mutations of the beta-catenin gene also occur in some cases ofhepatocellular carcinoma in humans. The team reached this conclusion af...

Antisense Therapy Prevents Burkitt's Lymphoma In Mice

...no longer generate excessmyc proteins that lead to uncontrolled blood-cell proliferation and cancer. Dr. Wickstrom notes that antisense therapy currently is being studied inclinical trials by some researchers. In his newly published book, "ClinicalTrials of Genetic Therapy with Antisense DNA and DNA Vect...

Molecular Circuit Breaker Can Prevent Runaway Cell Growth

...tiplication,but when these cease to work properly, uncontrolled cell growth can lead totumor formation. Sherr and St. Jude colleague Martine F. Roussel have beenstudying how some of these systems work at the molecular level. In 1995, the HHMI team discovered an unusual example of such a "checkpoint"whose key com...

Blacks' Environmental Concerns Equal/Exceed Whites'

... than whites to live within a mile and ahalf of an uncontrolled hazardous waste site (74 percent vs. 54 percent) or apolluting industrial facility (73 percent vs. 50 percent). In contrast, only 4 percent of Blacks, compared with 20 percent of whites, saidthat global issues, such as acid rain, ozone depletion, and...

Novel Two-Antibody Strategy To Fight Cancer Awarded Patent

...r complex thought to be involved instimulating the uncontrolled growth of a number of dangerous cancers, includingthose of the breast and the pancreas. Instructions for producing the p185protein in the cell are encoded by a gene known as neu. The recently approved anti-breast-cancer drug Herceptin also ac...

Researchers Find How Two Cancer Genes Interact To Cause Malignancy

...ctions whennormal, but act as accelerators to spur uncontrolled cell proliferation whenmutated. In normal cells, the amount of protein produced by the myc geneincreases to promote cell growth and then drops to prevent cells frommultiplying further. Ras is important in transmitting signals through the cell. In the...

New Discovery May Lead To Control Of Production Of Key Proteins

..., important forboth normal cell growth and in the uncontrolled cell growth of cancer; andproteins that directly affect heart function. The new results build upon previous discoveries by Brewer and hiscolleagues, dating back to 1986. One key discovery, in 1991, was of a proteinthat they called AUF1, which...

UCSF Scientists Report On A Transcription Factor That Could Stimulate Heart Cells To Repair Damage Caused By Heart Attacks Or Birth Defects

...uncover potential new targets fordrugs to stop the uncontrolled cell division in cancer. Using recombinant DNA techniques, Bernstein cloned hCdc5 in 1997 and showed thatit is a novel human protein involved in the division of human cells. Since then,he and his research team have shown that it binds to DNA and acts...

Suppression Of Natural Fires Harms Squirrels

...t from one populationpatch to others. Unlike hot, uncontrolled wildfires, the controlled burnsshould not destroy seeds of native plants, including some that require heat togerminate. -- Burned meadows are reseeded to reintroduce native plants that theground squirrels and other wildlife need. -...

Discovery Of Mechanism Causing Colon Cancer

...is a major regulator of cell growth, the result is uncontrolled cell proliferation. This contributes to abnormal tissue growth and the creation of a tumor. "In most cases, tumor formation is triggered by mutated genes. Therefore, it was unclear how completely normal copies of the cyclin D1 gene could be involve...

Fighting diabetes: UD researchers move closer to chip-based control of 'smart,' implantable insulin pumps

...rgeted range of 81 mg/dl, compared to patientswith uncontrolled diabetes, Parker says. Small delays in receiving data fromglucose sensors didn't seem to impair the performance of the UD system, whichdemonstrated a settling time of about 4.5 hours. Doyle predicts that "smart" implantable insulin pumps won't become...

Gene therapy trial using cold virus to begin at UK

...genes inhibit cell growth, acting as the brakes to uncontrolled cell growth anddivision. The most common gene that is mutated in ovarian cancers is a tumorsuppressor gene called p53. Data indicate that if you provide a copy of aworking p53 gene to a cell that has a malfunctioning p53 gene, growth of a tumorcan ...

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