Tag: "uncontrolled" at biology news

Three genetic steps convert normal mammary cells into breast cancer cells

...l help to understand the mechanisms underlying the uncontrolled and destructive growth behavior of cancer. The gen...othesis that cancer is not only the autonomous and uncontrolled growth of a transformed cell, but that it also relies on a specific cross-talk between the tumor and...

Cancer's penchant for developing drug resistance is a result of chromosome reassortment, UC Berkeley scientist proposes

... series of genetic mutations that kick a cell into uncontrolled growth. Instead, Duesberg argues, cancer results from a wrench thrown into the machinery - the spindle apparatus - controlling chromosome splitting when a cell divides. This leads to an abnormal number of chromosomes that unbalances hundreds to thous...

Oncogene spawns further mutation in breast cancer study

...ng to Chodosh, cancer is basically the progress of uncontrolled cell reproduction. The mechanisms that cells use to divide go out of control, which causes the cells to multiply out of control. As a cell divides it makes a copy of its own DNA, one for each new cell. The faster the reproduction, the more opportunit...

Trauma treatment from the sea

...hnology from the controlled clinical settings into uncontrolled traumatic situations encountered on the battlefield. During the seven major military operations since the Korean War, open wounds to the extremities have been the most prevalent battlefield injury. Medical treatment of in the battlefield requires sp...

Researchers link failed cell division, Alzheimer's disease

...urnal of Neuroscience." Cancer is characterized by uncontrolled cell division. In this study, scientists found uncontrolled cell division, arrested in the midst of the process, is the likely cause of the nerve cell destructi...

Gene therapy for diabetic neuropathy

...ment may not led to complications that result from uncontrolled vascular growth in other tissues....

Researchers find first gene that increases risk of Crohn's disease

...iral or bacterial agents and initiates an ongoing, uncontrolled inflammation of the intestine. Treatments are based on controlling inflammation through suppressing the immune response. The disease tends to cluster in certain families, suggesting that genes play an important role. This finding connects the di...

A letter to President Bush

...mpromise will minimize the current unnecessary and uncontrolled destruction of human embryos for research and therapy. There are currently no laws that forbid isolation of stem cells from embryos or fetuses by private companies. Many companies are rushing to take advantage of the governmental indecision on this m...

Knockout of cav-1 protein causes loss of a cellular organelle

...ed dramatic thickening of alveolar septa caused by uncontrolled endothelial cell proliferation and fibrosis. These defects resulted in severe physical limitations in caveolin-1-disrupted mice but were not lethal. These data demonstrate a fundamental role of caveolin-1 and caveolae in organizing multiple signallin...

Genetic mutation may be key to onset of deadly skin cancer

...16/Ink4a in early melanomas and lifts the brake on uncontrolled cancer cell growth, various mutations or other DNA changes must also occur to the p16/Ink4a gene to damage it beyond repair. So, as the cancer progresses, Id1 becomes less important for shutting off the gene. This may explain why we see lower expre...

Fatal thrombotic disease in designer mice lacking vascular thrombomodulin

... lack of TM, confirming that the disease is one of uncontrolled thrombosis. Males and females show different rates of disease progression in this strain, but the basis of this effect and the possible relation with the coincidence of disease and sexual maturity remain mysterious....

Rutgers professor details how polymers improve drug delivery and make possible crystal-clear water-based cosmetics

...n break them up and allow the drug to escape in an uncontrolled fashion. Uhrich reports that adding a small amount of ASM polymer to the liposome solution resolves both the water solubility and drug control problems because it stabilizes the liposomes. "It appears that it takes only a small amount of the polyme...

Fly genetics point to potential cancer-causing gene

...ave irregular cyclin E regulation that can lead to uncontrolled growth. The protein encoded by the ago gene may be crucial for this regulation. "The ago protein takes cyclin E to the destruction machinery in the cell. Cells that have mutated, inactive forms of the ago protein may have a growth advantage over n...

Loss of new cell growth gene linked to certain human cancers

... Cables protein may be important for thwarting the uncontrolled cell growth that is indicative of cancer. Without the protein, cells may be able to divide faster and could eventually become cancerous if they have a growth advantage over neighboring cells. The next step for the MGH researchers is to try to prove ...

Gene silencing produces disease resistance in plants

...It is this hormonal overproduction that results in uncontrolled cell growth and gall formation. Thus, by using the gene-silencing technique, the researchers produced genetically engineered plants that could still be infected by Agrobacterium tumefaciens but would not produce the hormones that lead to gall formati...

Nearly two-thirds of GPs are unaware that insulin resistance, a fundamental cause of type 2 diabetes, is thought to be present in 92% of people with the disease

...ned would introduce a TZD in a patient found to be uncontrolled using conventional monotherapy1**, perhaps meaning that the full potential of available treatments is not being realised. These survey results highlight the need for greater understanding of the prevalence of insulin resistance to enable GPs to make ...

Scientists using gene chips identify a unique form of leukemia

...e that may prove critical in causing the leukemias uncontrolled growth. It jumped off the page in the data analysis, said Golub. The gene is called flt-3 and it makes an enzyme known as a tyrosine kinase that fuels cell growth. In MLL, the flt-3 gene is stuck in the on position and may contribute to the defectiv...

Study of key enzyme sheds new light on programmed cell death and may lead to new drugs for reducing the severity of stroke

...o be important. The view of cancer as a disease of uncontrolled cell growth is gradually being expanded by its additional characterization as a disease resulting from malfunctions in the process of cell death. Reductions in DAPK expression have been found in a variety of different types of human cancer. In this c...

Required activation 'cascade' identified for p53 tumor-suppressor protein

...nts one of the body's leading defenses against the uncontrolled growth of cancers as a result. Damaged variants of the tumor-suppressor p53 protein have been found in more than half of human cancers. Now, in a new study, researchers at The Wistar Institute have identified a carefully orchestrated series of molecu...

Reining in cancer

...the chemical pathway that the EGFR uses to promote uncontrolled cell division. The drug is currently being tested as a single agent in combination with cytotoxic therapy in clinical trials in a range of cancers. In fact, expression of the EGFR frequently occurs in a majority of human cancers. Breast cancer cells...

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