Tag: "uncontrolled" at biology news

Protein found that turns off systemic inflammation in mice

...roteins led to fatal kidney failure, the result of uncontrolled systemic inflammation. Studies have also revealed which genes were affected by the missing off-switch, a protein called stat3-beta, says Stephen Desiderio, M.D., Ph.D., an author of the report in the Feb. 8 issue of Cell. Future studies may prove so...

Viral protein may be associated with human brain tumors

...In the absence of PML, JCV may stimulate rapid and uncontrolled cell growth, leading to cancer, the authors note. The virus is transmitted early in life, infecting 65% of children by the age of 14. The virus is most likely transmitted through the parent, the authors note, and may enter a child's developing brain ...

Genomics, internationally recognized speakers to figure prominently in upcoming symposium

... normal cells divide and the mechanisms behind the uncontrolled growth of cancer cells. Collins, a physician-geneticist and 1977 graduate of UNC-Chapel Hill School of Medicine, directs the National Human Genome Research Institute at NIH. Symposium registration is required, deadline April 12. Individuals plannin...

Cell Pathways CP461 demonstrates multiple anti-cancer activities

... cells. An ideal anti-cancer agent would halt the uncontrolled growth or proliferation of abnormal cells while at the same time selectively promoting apoptosis or programmed cell death, said Rifat Pamukcu, M.D., chief scientific officer of Cell Pathways, Inc. This research demonstrates that CP461 acts against ca...

Greatest threat to Asia's wildlife is hunting, scientists say

... Wildlife Conservation Society (WCS) have declared uncontrolled hunting and trade the greatest threat to wildlife ...ho still rely on wildlife for their daily protein, uncontrolled trade is threatening their livelihoods, according to WCS. Trans-boundary trade in wildlife threaten...

Popular weed killer demasculinizes frogs, disrupts their sexual development

...use of atrazine in the environment is basically an uncontrolled experiment - there seems to be no atrazine-free environment," Hayes said. "Because it is so widespread, aquatic environments are at risk." Because the herbicide has been in use for 40 years in some 80 countries, its effect on sexual development in ma...

UCSF finding offers provocative insight into what drives cancer

...f events that lead to cancer. These events include uncontrolled cell proliferation; loss of ability to specialize, or differentiate; the development of a blood vessel system, or angiogenesis; and the migration and interaction of a tumor with neighboring cells and surrounding tissue. The UCSF-led study calls thi...

Ominous signs of cryptic marine invasions

...alization of invasive organisms represents a huge, uncontrolled experiment with potentially disastrous environmental and economic consequences. Lampreys and Zebra Mussels destroyed Great Lakes fisheries; the Nile Perch and Water Hyacinth took over Lake Victoria. But another class of invaders may be wreaking hav...

Scientists identify the 'Bin Laden' of cancer causing faulty proteins

...cells just the two mutations that would create the uncontrolled c-Myc. Their experiments showed that they were co...es. The researchers find several parallels between uncontrolled c-Myc and Bin Laden. This research makes c-Myc one of the biggest target for those seeking to develo...

Genetic discovery in fruit flies may open new avenues for understanding cancer growth in humans

...rong time or turn on inappropriately can result in uncontrolled cell growth and malignancy.Understanding the mechanisms that turn genes on and off during normal development is crucial for decoding - and ultimately correcting - any flawed and potentially fatal operating instructions within cells that may lead to c...

New drug shows promise in common and lethal form of leukemia

...ates for the trial. AML, which is characterized by uncontrolled growth of the myeloid cells in the blood and bone marrow, strikes more than 10,000 adults and children each year in the U.S. It is the most common form of adult leukemia and the second most common type of childhood leukemia....

Science editor explores the role of environmental change on global security

... we seem to be doing little about it. He cited the uncontrolled discharge of ballast water from ships at ports around the world a practice that has been blamed for spreading tropical diseases and introducing countless exotic marine organisms that compete with native species. The prospect of new outbreaks of in...

Promising new therapies for deadly form of leukemia

...y disrupts the blood cells' development and causes uncontrolled proliferation. The most common form of FLT3 gene mutation creates an "internal tandem duplication" (hence the designation FLT3-ITD) that creates an abnormal FLT3 receptor that promotes the growth and survival of cancerous cells. "The FLT3 receptor ...

Researchers suggests a potentially damaging effect of extremely low frequency electromagnetic fields

...by ionising radiation, for example, it can lead to uncontrolled growth and the development of cancer. The research in Cancer Cell International examines the effects of combined ELF-EMF and ionising radiation on human cells. The researchers could not find any change in the process of cell division in cells expose...

What inspires yeast cells to divide?

...t this system of checks and balances, resulting in uncontrolled cell growth, DNA damage and eventually tumors. This breakdown in the cell cycle is caused by genetic mutations that lead to abnormal quantities of cell cycle proteins, such as the cyclins. Cellular oscillators The latest findings also suggest a ...

Surprise, surprise, surprise: Hopkins scientists unexpectedly create epilepsy in rats

... characterized not by cell death, but by rapid and uncontrolled "firing" of brain cells. Aware that extra amounts of the messenger can kill brain cells by over-stimulating them, the scientists thought preventing it from getting into cells might lead to cell death. But blocking one of the messenger's main transpo...

Scientists at TSRI receive $9.6 million to develop treatment for common cause of vision loss

...ss do so as a result of abnormal angiogenesis, the uncontrolled growth of new blood vessels in the back of the eye. The leading cause of vision loss in patients who are above the age of 65 is macular degeneration. Twelve to fifteen million people in this country alone have macular degeneration, and 10 to 15 perce...

Laboratory study explains clinical promise of anti-angiogenesis cancer drug

...ocess that goes on constantly in the body, and the uncontrolled angiogenesis seen in cancer. Researchers found that copper was important to various "growth factors" that are necessary to the organizing process by which cells become part of new blood vessels. Spurred by these discoveries, Merajver and Brewer teame...

Researchers elucidate machinery of major anti-cancer target

... become constantly active and thereby help trigger uncontrolled cancerous cell growth. Mutant Ras enzymes are asso...her substrates of the enzyme that are important in uncontrolled growth.Almost five years ago, Beese and Casey reported the first detailed structure of the FTase pro...

The role of obesity and calories in cancer prevention

...sor gene that acts like a brake to protect against uncontrolled cell proliferation) and also had high mammary gland expression of Wnt-1 (an oncogene that acts like an accelerator to enhance cell proliferation). Female p53-deficient Wnt-1 transgenic mice provided with unlimited access to food became obese and rap...

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