Progress In Prion Research: Three-Dimensional Structure Of Prion Protein Fully Uncovered
...tion to this question. They are the first to fully uncover the complete,three-dimensional structure of the normal prion protein. Compared with its normal form, prion protein isolated from the brains of cowsafflicted with BSE has a higher proportion of so-called beta-sheet-containingfolds. This is where clum...Limits Of Life On Earth: Are They The Key To Life On Other Planets?
...thousands of years apart. The researchers hope to uncover extinct genes or gene fragments to compare with modern counterparts. What is the telltale signature of past life in extreme environments? The University of Rochester's Ariel Anbar and colleagues will study whether stable isotopes of key metabolic ...Emory University Fragile X Group Receives NIH Program Grant
...culture, transgenic mice and yeast systems to help uncover additional answers. The seven projects will be led by a diverse group of both establishedand newer Emory investigators, including Drs. Warren and Sherman; Ye Feng,Ph.D., assistant professor of biochemistry; Judy Fridovich-Keil, Ph.D.,...New Insights Into The Enigma Of Lengthening Longevity
...d of molecular biodemography seeks to uncover how variation at the microscopic level of genetic polymorphisms alters mortality trajectories at the macroscopic level of entire populations. As for nongenetic determinants of longevity, the importance of diet, stress, and r...Virginia Tech Biologists' Discoveries Could Help Target Cancer Treatment
...teractions requiredfor differentiation, we hope to uncover the details of one of the unifyingprinciples of differentiation: the molecular framework underlying a cell'sdecision to depart from the cell cycle and to enter into a program ofdifferentiation." The check for the continued research was presen...Priestly Gene Shared By Widely Dispersed Jews
...ation, it is possible to use thisset of markers to uncover otherwise obscured ancestral or historical links amongwidely scattered Jewish communities throughout the world today. In response to a question about genetic testing, Prof. Skoreckiemphasizes that this genetic analysis is used to help elucid...Envisioning Ions With INEEL-Developed Simulation
...ze environmental contaminants, decode DNA, andeven uncover illegal drugs in urinalysis samples. SIMION has also been used toanalyze components used in semiconductor manufacturing, indirectly improving theproduction of the very computers it runs on. "It's kind of pervasive," says Dahl, a Lockheed Martin Idah...Ribozymes Come Ready For Action
...catalytic strategies. She hopes futurestudies will uncover some of these strategies. "Having structures available willallow us to see what those active sites really look like and then we're able togo in and really ask much more specific questions using other techniques,"Doudna says. Doudna's work provides a......ngs of the National Academy ofSciences, could help uncover clues to the diagnosis and treatment of not onlyleukemia, but HIV and other viral infections. The research was funded by theNational Institutes of Health and The Wellcome Trust. "Using DNA from human cells, we developed an improved method for...Protein Adultery Revealed!: Mechanism Of Protein Folding Captured In Computer Simulation
...ess." "Our next project is to apply our system to uncover clues about the mechanism ofmisfolding that occurs... Society, pioneered "wet" laboratoryexperiments to uncover protein-misfolding mechanisms. The conceptual leap The notorious complexity of simulating the fold...Autoimmune Diseases Study Shows Differences Between Men And Women
...bloodstream. The task force called for studies to uncover the actual cellularmechanisms for these differing effects. Hormones and the immunology of pregnancy: The levels of some hormoneswill vary with a woman's menstrual cycle. During pregnancy, some hormonesincrease while others decrease. For...Researchers Uncover 3-D Structure Of Virus Replication Technique
...usedby the AIDS virus. "This research will help us uncover some of the methods that viruses useto regulate the production of components that are essential to viralreplication. Knowledge of this mechanism may allow us to develop ways to modifythat process and thus lead to the development of new anti-viral ag...Yeast Provides Evidence For Continuous Membrane Theory
...antage of the differences between thetwo yeasts to uncover the mechanisms that produce tER sites." Like Pichia, mammalian cells have discrete tER sites that give rise toGolgi cisternae. By using yeasts as a model system, the researchers hope toarrive at a broad understanding of how Golgi stacks are ......lts orcontinues, knowledge about its actions could uncover potential new targets fordrugs to stop the uncontrolled cell division in cancer. Using recombinant DNA techniques, Bernstein cloned hCdc5 in 1997 and showed thatit is a novel human protein involved in the division of human cells. Since then,he and hi......ng in the fall of 2000, will helpthe scientists to uncover the mechanisms of infectious and parasitic diseasesand identify "Microbial, viral and parasitic diseases are global health problems,"said Purnell W. Choppin, HHMI's president. "Hundreds of millions of people areinfected with the organisms t...NYU scientists discover gene for a dementing brain disease
...s exciting discovery provides new opportunities to uncover the cascade of events leading to the loss of synapses and neurons triggering the development of dementia. If we can interfere with this cascade, common to many of the dementias, including Alzheimer's, we may be able to stall the disease process in it...Blocking VEGF can enhance radiation therapy
...ted with radiation andanti-VEGF took nine days. To uncover how the combination altered tumor growth, the researchers exposedhuman tumor cells and blood vessel cells in the test tube to VEGF, anti-VEGF andradiation. Neither VEGF nor anti-VEGF affected tumor cells, but adding VEGFprotected blood vessel cells f...Social behavior transformed with one new gene
... issue of the journal Nature. In trying to uncover the neurochemical mechanisms behind bonding andattachment, Drs. Tom Insel and Larry Young have long studied vasopressin, anaturally occurring peptide hormone produced in the brains of most mammals,including humans. In voles, the scientists previousl...Study finds prenatal exposure to testosterone boosts smoking
...s in mothersand daughters' later smoking. They did uncover a distinct correlation, however,between mothers' testosterone and daughters' smoking. Researchers analyzed information from 240 pairs of mothers and daughtersinvolved in research known as the Child Health and Development Study. Theycontrolled ...Major grants support immunology, transplant and diabetes research at the University of Chicago
... result from these new therapies. Theseefforts to uncover exactly what triggers rejection could serve as a guide todevelop even more effective therapies. "Every one of us who has diabetes, or who has children with diabetes, knows thatinsulin is not a cure," said JDF Chairman of the Board John J. McDonough. ...