DNA lends scientists a hand, revealing new chemical reactions
...k together, their associated organic molecules can undergo a chemical reaction to generate a product. Because...is to scan for pairs of reactants that are able to undergo chemical reaction under a chosen set of reaction conditions. Liu's team first applied DNA-templated ...Alzheimer's disease is not accelerated aging
... temporal lobe and other regions of the brain that undergo atrophy and reduced glucose metabolism, and appear to be involved in memory impairment. "We see profound disturbances in the medial temporal lobe memory system across methods--in studies of volume, function, and now showing what we think is the patho...Cardiac arrest may hinder ability to learn certain tasks
...em. The neurons that do survive a heart attack may undergo major structural changes that can affect learning, memory and other behaviors, said Courtney DeVries, the study's lead author and an assistant professor of psychology and neuroscience at Ohio State University. Indeed, in the current study the mice...Punching the timeclock of life
...programmed aging. But, most likely, most organisms undergo programmed longevity. Life is programmed. Whether death is programmed or not is yet to be determined." ...Study explores gene transfer to modify underlying course of Alzheimer's disease
...he same group of cells (cholinergic neurons) which undergo severe degeneration and death in Alzheimer's disease patients. NGF restored atrophied (shrunken) brain cells to near-normal size and quantity and also restored axons connecting the brain cells, essential for communication between cells. In humans, lo...Prion propagation: Avoiding the toxic oligomer
...ed monomers initially support fiber growth, fibers undergo fragmentation, and monomers rapidly grow from the broken ends. Weissman and colleagues confirmed that the fibers were growing monomer by monomer by attaching to fragmented fiber ends with fluorescent microscopy, which can detect single molecules. ...European common frog found to use novel mating strategy
...aid, there is no opportunity, as with animals that undergo internal fertilization, for more than one male to impregnate a female. And unlike the females of some frog species, the common frog will not lay eggs if clasped by two males. Since as many as one-third of the eggs may not be fertilized by the first m......e been established, the cells in the border region undergo a transformation, acquiring the polarized structure and properties of epithelial cells. This results in a somite body in which an outer layer of epithelial cells surrounds a mesenchymal core. Takahashi et al. focused on this mesenchymal-epithelial t...Researchers report new gene test for isolated cleft lip and palate
...ually correctable with several surgeries, families undergo tremendous emotional and economic hardship during the process. Children with this condition often require many other services, including complex dental care and speech therapy. "These results show that a specific gene plays a crucial role in the deve...Story tips from the Department of Energy's Oak Ridge National Laboratory, September 2004
...nt component in the deep Earth, and was thought to undergo an abrupt transformation from low to high density forms. This study shows a more complex slow transformation -- a significant finding with general implications for glass chemistry. The work, which will be featured an upcoming issue of Physical Review...Skin stem cells give hairless mice hair
...ular interest to clinicians was whether they could undergo division in a lab dish and still have the capability to perform either epidermal repair or hair-follicle generation." To answer those questions, Fuchs and her colleagues first isolated stem cells from the bulge by fusing antibodies to characteristic...Researchers uncover secrets of immune system's munitions factory
...t, was that for AID to interact with RPA, AID must undergo some modification in B cells a clue to the nature of the machinery that initiates somatic hypermutation, and a topic for future studies in Alt's lab. Identifying RPA's involvement could have implications for understanding lymphomas. "Lymphomas and s...Carnegie Mellon scientists reveal ways of studying, resolving PCB contamination in US rivers
...estigators have shown for the first time that PCBs undergo no biological breakdown whatsoever in river sediments with low but detectable dissolved oxygen levels. The findings up-end assumptions that some microbes either those that use oxygen or those that don't are always at work to break down these toxins...Scientists reinvent DNA as template to produce organic molecules
... bond together, their associated organic molecules undergo a chemical reaction to generate a product. As a result, the DNA strands essentially serve as a miniature, sequence-programmable assembly line for products of chemical synthesis. Because the resulting synthetic compounds are linked to DNA, techniques ...Innovative 'ceramic-on-metal' hip replacements to undergo clinical trials
...lasting than conventional artificial joints, is to undergo clinical trials and could be available for patient...r the age at which it is practical for patients to undergo hip replacement, helping them to continue to lead active lives. The limitations of conventional arti...Researchers report new gene test for isolated cleft lip and palate
...ually correctable with several surgeries, families undergo tremendous emotional and economic hardship during the process, and children often require many other services, including complex dental care and speech therapy. The challenge has been how to move the field forward. Isolated clefts arise during fet...The first engineering of cell surfaces in living animals
...fy the cells of a living animal so that they could undergo a chemical reaction without physiological harm," says Bertozzi. "It was a particular challenge because the living animal is such a complex reaction vessel." The researchers report their results in the 19 August 2004 issue of Nature. Key to their su...Progress in breast cancer progression
...nvade other tissues. Using a cell line that would undergo this transition when given a growth factor, the au... NF-kB activity was blocked, these cells could not undergo the transition. Furthermore, if the NF-kB pathway was over-activated, the cells no longer required ...JCI table of contents, 16 August, 2004
...invade other tissues. Using a cell line that would undergo this transition when given a growth factor, the au... NF-kB activity was blocked, these cells could not undergo the transition. Furthermore, if the NF-kB pathway was over-activated, the cells no longer required ...Infant rats eagerly accept high concentrations of alcohol upon first exposure
...f alcohol acceptance, especially brain mechanisms, undergo substantial changes from infancy to adulthood." Spear said that his study also showed that the high blood alcohol levels obtained were largely due to active drinking, not just inhalation or absorption through the skin. "Establishing unusually high...